Molecular mechanisms of oxidative stress‐related neonatal jaundice

Perrone, Serafina; Lembo, Chiara; Giordano, Maurizio; Petrolini, Chiara; Cannavò, Laura; Gitto, Eloisa

doi:10.1002/jbt.23349

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…It is important, however, to remember that a certain level of bilirubin in the newborn's blood could be beneficial due to the protective antioxidant effect of bilirubin on cell membranes. Under the influence of phototherapy, bilirubin levels decrease, and this may weaken this protective effect and make cell membranes more sensitive to damage [19].…”

Section: Severe Nhb and Bilirubin Encephalopathymentioning

confidence: 99%

“Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature

Shoris,

Gover,

Toropine

et al. 2023

Children

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Neonatal hyperbilirubinemia is an extremely common metabolic complication of the neonatal period which may be associated with bilirubin encephalopathy and even death. Adverse neurological consequences are preventable if a timely diagnosis and treatment are provided. Phototherapy is usually the preferred option to decrease hyperbilirubinemia. Although considered to be safe, evidence in recent years has shown that this treatment may not be free of side effects and short- and long-term unfavorable outcomes. These are usually mild or rare, but should be decreased or avoided if possible. Many useful complementary measures and treatments have been described that could shorten the duration of exposure to phototherapy. However, there is no current unequivocal recommendation to use any of the methods presented in this review. Our review aims to depict the wide range of possible complementary treatments to phototherapy, and to provide the scientific and clinical evidence available regarding their usefulness. It is essential that, while utilizing the full potential of phototherapy to treat hyperbilirubinemia, caregivers are aware of its side effects and possible inherent dangers, and seek ways to minimize the exposure to phototherapy to what is really needed for the newborn. Further studies are needed to clarify the preferred complementary treatments that could reduce the duration of exposure to phototherapy without impairing its effectiveness.

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Section: Severe Nhb and Bilirubin Encephalopathymentioning

confidence: 99%

“Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature

Shoris,

Gover,

Toropine

et al. 2023

Children

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Altered trace elements, antioxidant vitamin C, and malondialdehyde levels are associated with the pathophysiology and development of pre-hepatic jaundice: A case-control study

Dewan,

Das,

Ahmed

et al. 2024

SAGE Open Medicine

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Objectives: Pre-hepatic jaundice results from an imbalance between bilirubin production and clearance, often linked to hemoglobinopathies. Antioxidant vitamin C, malondialdehyde, and trace elements play roles in jaundice, yet their specific associations remain unclear. The objective is to assess and compare these biomarkers in pre-hepatic jaundice patients and healthy controls, aiming to identify potential diagnostic markers and understand distinctive characteristics related to the disease’s pathogenesis. Methods: This case–control study enrolled 50 pre-hepatic jaundice patients and 50 healthy controls, utilizing advanced techniques for biomarker quantification. We completed blood sample collection from study participants between 1 September 2023 and 31 December 2023. This study investigates the correlation between various biomarkers and pre-hepatic jaundice using serum samples with a focus on antioxidant vitamin C, malondialdehyde, and trace elements. Results: This study demonstrates elevated concentrations of malondialdehyde in patients with pre-hepatic jaundice, suggesting alterations in bilirubin metabolism and increased oxidative stress. We found that the serum levels of malondialdehyde were significantly higher in pre-hepatic jaundice patients compared to healthy controls. Our observations revealed a notable decrease in the average serum vitamin C levels in patients with pre-hepatic jaundice compared to healthy controls. The patients had lower serum Zn levels and higher serum Cu and Mn levels compared to the healthy controls. The correlation study demonstrates robust positive correlations among these biomarkers in pre-hepatic jaundice. As the levels of vitamin C rise, the levels of the other criteria often fall, and vice versa. There is an inverse relationship between higher levels of vitamin C and lower levels of malondialdehyde. The current investigation identifies possible changes in antioxidant vitamins, malondialdehyde levels, and trace elements, which provide significant insights for targeted interventions. Conclusions: The present research highlights the integrated significance of vitamin C, malondialdehyde, and trace elements in the progression of the disease.

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Redox Status of Erythrocytes as an Important Factor in Eryptosis and Erythronecroptosis

Tkachenko,

Havránek

2023

Fol. Biol.

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Overall, reactive oxygen species (ROS) signalling significantly contributes to initiation and modulation of multiple regulated cell death (RCD) pathways. Lately, more information has become available about RCD modalities of erythrocytes, including the role of ROS. ROS accumulation has therefore been increasingly recognized as a critical factor involved in eryptosis (apoptosis of erythrocytes) and erythronecroptosis (necroptosis of erythrocytes). Eryptosis is a Ca2+-dependent apoptosis-like RCD of erythrocytes that occurs in response to oxidative stress, hyperosmolarity, ATP depletion, and a wide range of xenobiotics. Moreover, eryptosis seems to be involved in the pathogenesis of multiple human diseases and pathological processes. Several studies have reported that erythrocytes can also undergo necroptosis, a lytic RIPK1/RIPK3/MLKL-mediated RCD. As an example, erythronecroptosis can occur in response to CD59-specific pore-forming toxins. We have systematically summarized available studies regarding the involvement of ROS and oxidative stress in these two distinct RCDs of erythrocytes. We have focused specifically on cellular signalling pathways involved in ROS-mediated cell death decisions in erythrocytes. Furthermore, we have summarized dysregulation of related erythrocytic antioxidant defence systems. The general concept of the ROS role in eryptotic and necroptotic cell death pathways in erythrocytes seems to be established. However, further studies are required to uncover the complex role of ROS in the crosstalk and interplay between the survival and RCDs of erythrocytes.

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Molecular mechanisms of oxidative stress‐related neonatal jaundice

Cited by 4 publications

References 65 publications

“Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature

“Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature

Altered trace elements, antioxidant vitamin C, and malondialdehyde levels are associated with the pathophysiology and development of pre-hepatic jaundice: A case-control study

Redox Status of Erythrocytes as an Important Factor in Eryptosis and Erythronecroptosis

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