Molecular Mechanisms of Periodontal Disease

Kajiya, Mikihito; Kurihara, Hidemi

doi:10.3390/ijms22020930

Cited by 15 publications

(19 citation statements)

References 19 publications

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“…miR-103a-3p was down-regulated in placentas from pregnancies with preeclampsia [ 156 ]. Moreover, its exosomal expression from placental trophoblast increases due to exposure to glucose concentration [ 157 ].…”

Section: The Maternal Periodontal Disease In Pregnancy and Consequenc...mentioning

confidence: 99%

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Starzyńska

Wychowański

Nowak

et al. 2022

IJMS

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Periodontal disease (PD) is one of the most common oral conditions affecting both youths and adults. There are some research works suggesting a high incidence of PD in pregnant women. As an inflammatory disease of bacterial origin, PD may result in the activation of the pathways affecting the course and the pregnancy outcome. The authors, based on the literature review, try to answer the PICO question: Does maternal periodontitis (exposure) influence the incidence of complications rates in pregnancy and the development of systemic diseases in childhood and adult offspring (outcome) in the humans of any race (population) compared to the offspring of mothers with healthy periodontium (comparison)? The authors try to describe the molecular pathways and mechanisms of these interdependencies. There is some evidence that maternal periodontitis may affect the pregnancy course and outcome, resulting in preeclampsia, preterm delivery, vulvovaginitis and low birth weight. It can be suggested that maternal periodontitis may affect offspring epigenome and result in some health consequences in their adult life.

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Section: The Maternal Periodontal Disease In Pregnancy and Consequenc...mentioning

confidence: 99%

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Starzyńska

Wychowański

Nowak

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Periodontal disease is an inflammatory disorder that drives catabolic cellular events, ultimately leading to tooth loss due to a lack of supporting tissues [ 1 , 2 , 3 ]. It is fundamental to understand the pathological mechanisms on a cellular and molecular basis to implement therapies aiming to modulate inflammation and allow for regenerative strategies.…”

Section: Introductionmentioning

confidence: 99%

TGF-β Signalling Mediates the Anti-Inflammatory Activity of Enamel Matrix Derivative In Vitro

Panahipour

Sordi

Kargarpour

et al. 2022

IJMS

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Enamel matrix derivative (EMD) prepared from extracted porcine fetal tooth material can support the regrow of periodontal tissues. Previous findings suggest that EMD has anti-inflammatory properties and TGF-β activity in vitro. However, the anti-inflammatory activity of EMD is mediated via TGF-β has not been considered. To this aim, we first established a bioassay to confirm the anti-inflammatory activity of EMD. The bioassay was based on the RAW 264.7 macrophage cell line and proven with primary macrophages where EMD significantly reduced the forced expression of IL-6. We then confirmed the presence of TGF-β1 in EMD by immunoassay and by provoking the Smad2/3 nuclear translocation in RAW 264.7 macrophages. Next, we took advantage of the TGF-β receptor type I kinase-inhibitor SB431542 to block the respective signalling pathway. SB431542 reversed the anti-inflammatory activity of EMD and TGF-β in a bioassay when IL-6 and CXCL2 expression was driven by the LPS stimulation of RAW 264.7 macrophages. This central observation was supported by showing that SB431542 reversed the anti-inflammatory activity of EMD using IL-1β and TNF-α-stimulated ST2 bone marrow stromal cells. Together, these findings implicate that the TGF-β activity mediates at least part of the anti-inflammatory activity of EMD in vitro.

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“…These receptor types include toll-like receptors, nucleotide-binding oligomerization domain (NOD) proteins, cluster of differentiation 14 (CD14), complement receptor-3, lectins, and scavenger receptors [ 20 , 21 ]. The toll like receptors plays a crucial role in the progression of periodontal/peri-implant inflammation and bone resorption [ 22 ]. It has been reported that PAMPs activates T and B cells’ immune response leading to activation of cytokines and osteolytic pathway [ 22 ].…”

Section: Dental Biofilm and Its Relation To Periodontal And Peri-implant Diseasesmentioning

confidence: 99%

“…The toll like receptors plays a crucial role in the progression of periodontal/peri-implant inflammation and bone resorption [ 22 ]. It has been reported that PAMPs activates T and B cells’ immune response leading to activation of cytokines and osteolytic pathway [ 22 ]. In conjunction with innate immunity, periodontal and peri-implant tissue produces various cytokines and chemokines which maintain the equilibrium.…”

Section: Dental Biofilm and Its Relation To Periodontal And Peri-implant Diseasesmentioning

confidence: 99%

Novel Approach to Dental Biofilm Management through Guided Biofilm Therapy (GBT): A Review

et al. 2021

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Dental biofilm plays a very crucial role in the etiopathogenesis of periodontal andperi-implant diseases. Over the past decade, tremendous research has been carried outto know the structure of biofilm and the mechanism by which it causes the destruction of supporting tissues of tooth or implant. Periodontal or peri-implant therapy usually begins with primarily removing thebiofilm and is considered as non-surgical mechanical debridement. Although scaling and root planing (SRP) is regarded as a gold standard for mechanical plaque debridement, various other means of biofilm removal have constantly been evolving. These may vary from different scaling systems such as vector systems to decontamination of pockets with LASER therapy. Nowadays, a new concept has emerged known as “guided biofilm therapy” (GBT). It is beneficial in removing the biofilm around the tooth and implant structures, resulting in better or comparable clinical outcomes than SRP. These results were substantiated with the reduction in the microbial load as well as the reduction in the inflammatory cytokines. This review will highlight the various aspects of GBT used in periodontal and peri-implant disease.

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Molecular Mechanisms of Periodontal Disease

Abstract: Periodontal disease, one of the most prevalent human infectious diseases, is characterized by chronic inflammatory tissue destruction of the alveolar bone and the connective tissues supporting the tooth [...]

Cited by 15 publications

References 19 publications

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

TGF-β Signalling Mediates the Anti-Inflammatory Activity of Enamel Matrix Derivative In Vitro

Novel Approach to Dental Biofilm Management through Guided Biofilm Therapy (GBT): A Review

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