2023
DOI: 10.1128/mbio.01526-22
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Molecular Mechanisms of Poxvirus Evolution

Abstract: Poxviruses are often thought to evolve relatively slowly because they are double-stranded DNA pathogens with proofreading polymerases. However, poxviruses have highly adaptable genomes and can undergo relatively rapid genotypic and phenotypic change, as illustrated by the recent increase in human-to-human transmission of monkeypox virus.

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Cited by 39 publications
(32 citation statements)
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References 119 publications
(165 reference statements)
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“…It is worthy to note that virus attenuation was previously observed with the Myxoma virus in rabbits. 58,65 Another interesting observation in the present study is the high number of mutations (between 64 and 73) in MPXV genomes obtained here compared to the NC_063383.1 genome obtained from a human specimen collected in Nigeria in August 2018, which is in the same range than recently reported. 5,7,13,42 This corresponds to a greater mutation rate than that expected based on previous assessment for orthopoxviruses that was estimated to be 1−2 nucleotide substitutions per genome per year (i.e., approximately 10 −5 substitutions per site per year), 15,66 and might represent accelerated evolution.…”
Section: Metagenomic Analysis Of Ngs Runssupporting
confidence: 77%
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“…It is worthy to note that virus attenuation was previously observed with the Myxoma virus in rabbits. 58,65 Another interesting observation in the present study is the high number of mutations (between 64 and 73) in MPXV genomes obtained here compared to the NC_063383.1 genome obtained from a human specimen collected in Nigeria in August 2018, which is in the same range than recently reported. 5,7,13,42 This corresponds to a greater mutation rate than that expected based on previous assessment for orthopoxviruses that was estimated to be 1−2 nucleotide substitutions per genome per year (i.e., approximately 10 −5 substitutions per site per year), 15,66 and might represent accelerated evolution.…”
Section: Metagenomic Analysis Of Ngs Runssupporting
confidence: 77%
“…Anyway, gene loss is a known trait of poxvirus evolution, and it was notably suspected to be associated with a restricted host range but also with an efficient human‐to‐human spread in orthopoxviruses 1,33,57–59 . For instance, it was observed in MPXV genomes recovered from 10 of 60 specimens collected from humans between 2005 and 2007 in the Democratic Republic of the Congo 60 .…”
Section: Discussionmentioning
confidence: 99%
“…However, it is also well accepted that poxviruses can recombine under specific conditions to give chimeric viruses. The mechanisms include recombination, and horizontal gene transfer to acquire new genes [ 69 ]. The first experiments to show recombination between different orthopoxviruses were conducted in the 1960s [ 70 , 71 , 72 ].…”
Section: Introductionmentioning
confidence: 99%
“…Marker rescue studies were carried out to demonstrate how homologous recombination could be used to generate recombinant poxviruses with novel inserts [ 73 ] and this subsequently evolved into making recombinant poxvirus-based vaccines [ 74 ]. Poxviruses under specific stresses can duplicate genes to adapt to new conditions [ 69 , 75 , 76 ]. However, there was minimal evidence that Capripoxviruses would recombine in the field [ 77 ].…”
Section: Introductionmentioning
confidence: 99%
“…The origin and evolution of poxviruses remain obscure, despite evidence that poxviruses emerged thousands of years ago. Poxvirus genomes evolved through the acquisition and loss of genes, especially gene replication and horizontal gene transfer, to adapt to and combat the host’s antiviral immune defenses to establish successful infection [ 3 ]. Parapoxvirus belongs to Chordopoxvirinae, a vertebrate Poxviridae, and is one of the most commonly studied genera of poxvirus.…”
Section: Introductionmentioning
confidence: 99%