Molecular mechanisms of TACE refractoriness: Directions for improvement of the TACE procedure

Li, Jiahao; Liu, Yingnan; Zheng, Ruipeng; Qu, Chao; Li, Jiarui

doi:10.1016/j.lfs.2024.122540

Life Sciences

2024

DOI: 10.1016/j.lfs.2024.122540

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Molecular mechanisms of TACE refractoriness: Directions for improvement of the TACE procedure

Jiahao Li,

Yingnan Liu,

Ruipeng Zheng

et al.

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Cited by 5 publications

References 213 publications

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Rhein‐based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization

Liang,

Liu,

Chen

et al. 2024

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The efficacy of transarterial chemoembolization (TACE) has been limited by insufficient embolization and a high incidence of tumor recurrence. Herein, we identified that aberrant metabolic reprogramming and immunosuppression contribute to TACE refractoriness and Rhein, as a potential glycolytic metabolism inhibitor and immunoactivation inducer, was optimized to sensitize tumors to TACE therapy. To achieve efficient embolization, we developed an oil‐in‐water lipiodol embolic emulsion by stabilizing the self‐assembled Rhein nanogel. The assembled Rhein exhibited a nanofiber network, and its integration enhanced the mechanical stability and viscoelasticity of the lipiodol embolic agent. With the synergistic advantages of solid and liquid embolic agents, this carrier‐free Pickering emulsion exhibits efficient embolization and sustained drug release in models of unilateral renal artery embolization, rabbit ear tumor embolization, rabbit orthotopic liver cancer, and rat orthotopic liver cancer. Compared to conventional three‐way catheter mixing methods, multimodal imaging corroborates a marked enhancement in local drug retention and tumor suppression. Importantly, the incorporation of Rhein‐mediated synergistic immunoembolization in this strategy achieved efficient embolization while robustly activating anti‐tumor immune responses, including inducing immunogenic cell death, dendritic cell activation, and major histocompatibility complex class I presentation to CD8+ T cells for tumor killing. Together, these findings reveal a novel strategy for the application of self‐assembled Rhein nanofiber‐stabilized lipiodol emulsion to control metabolic signaling and immunoactivation in TACE.

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Rhein‐based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization

Liang,

Liu,

Chen

et al. 2024

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Dynamic changes of radiological and radiomics patterns based on MRI in viable hepatocellular carcinoma after transarterial chemoembolization

Wang,

Zhang,

Zhong

et al. 2024

Abdom Radiol

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Proteomics efforts for hepatocellular carcinoma drug development

Jia,

Jiang,

Cui

et al. 2024

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Hepatocellular carcinoma (HCC) is a malignant tumor associated with high global incidence and mortality rates. Proteomics, as a platform technology of cellular protein expression, modification, and interaction, has provided innovative perspectives on early diagnosis, treatment, and targeted drug development for HCC. This review summarizes recent progress in proteomics for advancing HCC biomarker discovery, drug target identification, and understanding drug action mechanisms. Proteomic technologies, including mass spectrometry for specific protein signatures identification, protein microarrays for high-throughput analysis, and bioinformatics for data interpretation, have profoundly promoted the identification of liver cancer-specific biomarkers. These advancements not only facilitate early diagnosis but also improve prognostic assessment. Proteomics is pivotal in expediting the discovery and development of new drugs, providing more effective and personalized treatment options for HCC patients. This review offers a comprehensive overview of the applications of proteomics in anti-HCC drug research, serving as a reference to further advance the development of HCC research and treatment domains.

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Molecular mechanisms of TACE refractoriness: Directions for improvement of the TACE procedure

Cited by 5 publications

References 213 publications

Rhein‐based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization

Rhein‐based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization

Dynamic changes of radiological and radiomics patterns based on MRI in viable hepatocellular carcinoma after transarterial chemoembolization

Proteomics efforts for hepatocellular carcinoma drug development

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