Molecular mechanisms underlying actions of certain long noncoding RNAs in Alzheimer’s disease

Ahmadi, Shamseddin; Zobeiri, Mohammad; Bradburn, Steven

doi:10.1007/s11011-020-00564-9

Cited by 25 publications

(14 citation statements)

References 143 publications

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“…In a study of post-mortem specimens in the control group, BC-200 levels were reduced. However, in AD brains, compared with normal brains, BC-200 levels were significantly up-regulated (Ahmadi et al, 2020 ). Li et al showed that the expression BC-200 and BACE1 are increased in Aβ1-42 induced AD cell model.…”

Section: The Perspective Of Up-regulated Lncrnas In Admentioning

confidence: 99%

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Asadi

Hassani

Kiani

et al. 2021

Front. Aging Neurosci.

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LncRNAs act as part of non-coding RNAs at high levels of complex and stimulatory configurations in basic molecular mechanisms. Their extensive regulatory activity in the CNS continues on a small scale, from the functions of synapses to large-scale neurodevelopment and cognitive functions, aging, and can be seen in both health and disease situations. One of the vast consequences of the pathological role of dysregulated lncRNAs in the CNS due to their role in a network of regulatory pathways can be manifested in Alzheimer's as a neurodegenerative disease. The disease is characterized by two main hallmarks: amyloid plaques due to the accumulation of β-amyloid components and neurofibrillary tangles (NFT) resulting from the accumulation of phosphorylated tau. Numerous studies in humans, animal models, and various cell lines have revealed the role of lncRNAs in the pathogenesis of Alzheimer's disease. This scoping review was performed with a six-step strategy and based on the Prisma guideline by systematically searching the publications of seven databases. Out of 1,591 records, 69 articles were utterly aligned with the specified inclusion criteria and were summarized in the relevant table. Most of the studies were devoted to BACE1-AS, NEAT1, MALAT1, and SNHG1 lncRNAs, respectively, and about one-third of the studies investigated a unique lncRNA. About 56% of the studies reported up-regulation, and 7% reported down-regulation of lncRNAs expressions. Overall, this study was conducted to investigate the association between lncRNAs and Alzheimer's disease to make a reputable source for further studies and find more molecular therapeutic goals for this disease.

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Section: The Perspective Of Up-regulated Lncrnas In Admentioning

confidence: 99%

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Asadi

Hassani

Kiani

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

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“…51A regulates the alternative splicing of SORL1 mRNA, downregulating the production of the canonical variant of this receptor. These events can drive AD pathophysiology, as SORL1 has a neuroprotective property by binding to apolipoprotein E (APOE), which interacts with Aβ, reducing APP oligomerization in the BACE1 amyloid pathway [ 109 , 142 , 146 , 147 , 148 ].…”

Section: Lncrnas In Neurological and Neurodegenerative Disordersmentioning

confidence: 99%

Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders

Aliperti

Skonieczna

Cerase

2021

ncRNA

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Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be exploited as a novel target for treating neurological disorders. In our review, we first summarize the recent advances in our understanding of lncRNA functions in the context of cell biology and then discussing their association with selected neuronal development and neurological disorders.

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“…Abnormal lncRNA expression was detected not only in brain tissues but also in the peripheral blood and cerebrospinal fluid of patients with Parkinson’s disease ( 20 ). In parallel, several studies have posited that lncRNAs BACE1-AS, 17A, 51A, and NDM29 may directly or indirectly increase amyloid β protein formation and play a major role in the pathology of Alzheimer’s disease ( 21 ). Recent peripheral blood profiling studies also identified alterations in lncRNA expression patterns in patients with major depressive disorder ( 22 , 23 ) and schizophrenia ( 24 ).…”

Section: Introductionmentioning

confidence: 99%

Integration of Molecular Inflammatory Interactome Analyses Reveals Dynamics of Circulating Cytokines and Extracellular Vesicle Long Non-Coding RNAs and mRNAs in Heroin Addicts During Acute and Protracted Withdrawal

Zhang

Wu²,

Peng³

et al. 2021

Front. Immunol.

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Heroin addiction and withdrawal influence multiple physiological functions, including immune responses, but the mechanism remains largely elusive. The objective of this study was to investigate the molecular inflammatory interactome, particularly the cytokines and transcriptome regulatory network in heroin addicts undergoing withdrawal, compared to healthy controls (HCs). Twenty-seven cytokines were simultaneously assessed in 41 heroin addicts, including 20 at the acute withdrawal (AW) stage and 21 at the protracted withdrawal (PW) stage, and 38 age- and gender-matched HCs. Disturbed T-helper(Th)1/Th2, Th1/Th17, and Th2/Th17 balances, characterized by reduced interleukin (IL)-2, elevated IL-4, IL-10, and IL-17A, but normal TNF-α, were present in the AW subjects. These imbalances were mostly restored to the baseline at the PW stage. However, the cytokines TNF-α, IL-2, IL-7, IL-10, and IL-17A remained dysregulated. This study also profiled exosomal long non-coding RNA (lncRNA) and mRNA in the plasma of heroin addicts, constructed co-expression gene regulation networks, and identified lncRNA-mRNA-pathway pairs specifically associated with alterations in cytokine profiles and Th1/Th2/Th17 imbalances. Altogether, a large amount of cytokine and exosomal lncRNA/mRNA expression profiling data relating to heroin withdrawal was obtained, providing a useful experimental and theoretical basis for further understanding of the pathogenic mechanisms of withdrawal symptoms in heroin addicts.

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Molecular mechanisms underlying actions of certain long noncoding RNAs in Alzheimer’s disease

Cited by 25 publications

References 143 publications

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders

Integration of Molecular Inflammatory Interactome Analyses Reveals Dynamics of Circulating Cytokines and Extracellular Vesicle Long Non-Coding RNAs and mRNAs in Heroin Addicts During Acute and Protracted Withdrawal

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