Molecular mechanisms underlying glyphosate resistance in bacteria

Hertel, Robert; Gibhardt, Johannes; Martienssen, Marion; Kuhn, Ramona; Commichau, Fabian M.

doi:10.1111/1462-2920.15534

Cited by 37 publications

(30 citation statements)

References 178 publications

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“…As with other toxic compounds, bacteria may develop resistance by reducing membrane permeability, metabolism, or efflux. For glyphosate, resistance has been described as a result of efflux via a membrane transporter and metabolism mediated by an enzyme with a single base pair mutation in the gene aroA, that is typically responsible for the synthesis of aromatic amino acids [158]. Of concern is that laboratory experiments have demonstrated that the exposure of Salmonella enterica Typhimurium and E. coli to several commonly used herbicides (dicamba, 2,4,-dichlorophenoxyacetic acid, and glyphosate) changes the antimicrobial susceptibility of these organisms [159].…”

Section: Herbicidesmentioning

confidence: 99%

Antimicrobial Use and Resistance in Plant Agriculture: A One Health Perspective

2022

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Bactericides, fungicides, and other pesticides play an important role in the management of plant diseases. However, their use can result in residues on plants and in the environment, with potentially detrimental consequences. The use of streptomycin, oxytetracycline, copper-based products, and some fungicides is correlated with increased resistance among plant pathogens to these agents. Likewise, the recent rise in the incidence of environmental triazole fungicide-resistant Aspergillus fumigatus, the cause of aspergillosis in humans, has caused concern, particularly in Europe. Through horizontal gene transfer, genes can be exchanged among a variety of bacteria in the plant production environment, including phytopathogens, soil bacteria, and zoonotic bacteria that are occasionally present in that environment and in the food chain. Through mechanisms of horizontal gene transfer, co-resistance, cross-resistance, and gene up-regulation, resistance to one compound may confer resistance and multi-drug resistance to other similar, or even very dissimilar, compounds. Given the global rise in antimicrobial-resistant (AMR) organisms, and their effects on plant, animal, and human health, the prudent use of pesticides is required to maintain their effectiveness for food security and sustainable production, and to minimize the emergence and transmission of AMR organisms from horticultural sources.

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Section: Herbicidesmentioning

confidence: 99%

Antimicrobial Use and Resistance in Plant Agriculture: A One Health Perspective

2022

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“…Microorganisms present in aquatic environments may suffer selective pressure due to contact with herbicides ( Iori et al., 2020 ). Bacteria can be selected for specific resistance to glyphosate through the elevation of the production of the EPSPS; herbicide degradation; detoxification by covalent modification; and decreasing uptake and increasing export of herbicide ( Hertel et al., 2021 ). Nevertheless, we found no reports in the literature about response systems that were not induced by the selective pressure of specific xenobiotics.…”

Section: Resultsmentioning

confidence: 99%

Changes in fatty acid composition as a response to glyphosate toxicity in Pseudomonas fluorescens

Oliveira

Marchi

Emiliano

et al. 2022

Heliyon

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“…However, different molecular mechanisms underlying glyphosate resistance in bacteria were also highlighted demonstrating the adaptation capacity of some species thanks to genomic alterations, although A. kunkeei does not appear in such list. The mechanisms included an increased production of EPSPS, the degradation or detoxification of the herbicide, and the uptake decrease combined with an export increase of such agrochemical (Hertel et al ., 2021). Reldan, an organophosphorus insecticide, having a broad range of actions is used to eradicate pests from agricultural and farming regions (Nita‐Lazar et al ., 2016).…”

Section: Discussionmentioning

confidence: 99%

Biofilm formation as an extra gear for Apilactobacillus kunkeei to counter the threat of agrochemicals in honeybee crop

Tlais

Polo

Filannino

et al. 2022

Microbial Biotechnology

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The alteration of a eubiosis status in honeybees' gut microbiota is directly linked to the occurrence of diseases, and likely to the honeybees decline. Since fructophilic lactobacilli were suggested as symbionts for honeybees, we mechanistically investigated their behaviour under the exposure to agrochemicals (Roundup, Mediator and Reldan containing glyphosate, imidacloprid and chlorpyrifos-methyl as active ingredients respectively) and plant secondary metabolites (nicotine and p-coumaric acid) ingested by honeybees as part of their diet. The effects of exposure to agrochemicals and plant secondary metabolites were assessed both on planktonic cells and sessile communities of three biofilm-forming strains of Apilactobacillus kunkeei. We identified the high sensitivity of A. kunkeei planktonic cells to Roundup and Reldan, while cells embedded in mature biofilms had increased resistance to the same agrochemicals. However, agrochemicals still exerted a substantial inhibitory/control effect if the exposure was during the preliminary steps of biofilm formation. The level of susceptibility resulted to be strain-specific. Exopolysaccharides resulted in the main component of extracellular polymeric matrix (ECM) in biofilm, but the exposure to Roundup caused a change in ECM production and composition. Nicotine and p-coumaric acid had a growth-promoting effect in sessile communities, although no effect was found on planktonic growth.

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Molecular mechanisms underlying glyphosate resistance in bacteria

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 37 publications

References 178 publications

Antimicrobial Use and Resistance in Plant Agriculture: A One Health Perspective

Antimicrobial Use and Resistance in Plant Agriculture: A One Health Perspective

Changes in fatty acid composition as a response to glyphosate toxicity in Pseudomonas fluorescens

Biofilm formation as an extra gear for Apilactobacillus kunkeei to counter the threat of agrochemicals in honeybee crop

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