Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone

Ahn, Tae-Gue; Yang, Gabsik; Lee, Heon-Myung; Kim, Myung-Dong; Choi, Ho‐Young; Park, Kyoung-Sik; Lee, Sundong; Kook, Yoon‐Bum; An, Hyo‐Jin

doi:10.1016/j.bcp.2013.02.020

Cited by 52 publications

(43 citation statements)

References 43 publications

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“…SREBP is a transcription factor that plays an important role in mediating transcriptional control of adipogenesis. SREBP expression results in an accumulation of lipid droplets, cholesterol homoeostasis, and an increase in high levels of the serum lipid profile [28], as observed in the untreated obese mice in this study. Coconut water vinegar, especially at a concentration of 2 ml/kg BW, significantly suppressed the expression of SREBP in the adipose tissues compared to the untreated HFD-induced obese mice.…”

Section: Discussionmentioning

confidence: 56%

“…Obesity is always related to excessive adipogenesis, which is regulated by the differential expression of adipogenic transcription factors, adipokines, and glucose transporters [28,29]. SREBP is a transcription factor that plays an important role in mediating transcriptional control of adipogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, adiponectin is an adipokine with an inverse correlation with RBP4 and resistin. Adiponectin negatively regulates adipogenesis by enhancing the metabolism of energy [28,34]. Glut4 is the insulin-regulated glucose transporter found primarily in adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Its functions include supporting the lipogenesis and adipogenesis of adipocytes, thereby resulting in an excessive increase in adipose tissue [28]. Chronic obesity has been correlated with the development of liver disease owing to prolonged, mild inflammation induced by obesity [36,37].…”

Section: Discussionmentioning

confidence: 99%

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Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice

Mohamad

Yeap

Kỳ

et al. 2017

Food & Nutrition Research

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Obesity has become a serious health problem worldwide. Various types of healthy food, including vinegar, have been proposed to manage obesity. However, different types of vinegar may have different bioactivities. This study was performed to evaluate the anti-obesity and anti-inflammatory effects of coconut water vinegar on high-fat-diet (HFD)-induced obese mice. Changes in the gut microbiota of the mice were also evaluated. To induce obesity, C57/BL mice were continuously fed an HFD for 33 weeks. Coconut water vinegar (0.08 and 2 ml/kg body weight) was fed to the obese mice from early in week 24 to the end of week 33. Changes in the body weight, fat-pad weight, serum lipid profile, expression of adipogenesis-related genes and adipokines in the fat pad, expression of inflammatory-related genes, and nitric oxide levels in the livers of the untreated and coconut water vinegar-treated mice were evaluated. Faecal samples from the untreated and coconut water vinegar-treated mice (2 ml/kg body weight) were subjected to 16S metagenomic analysis to compare their gut microbiota. The oral intake of coconut water vinegar significantly (p < 0.05) reduced the body weight, fat-pad weight, and serum lipid profile of the HFD-induced obese mice in a dose-dependent manner. We also observed up-regulation of adiponectin and down-regulation of sterol regulatory element-binding protein-1, retinol-binding protein-4, and resistin expression. The coconut water vinegar also reduced HFD-induced inflammation by down-regulating nuclear factor-κB and inducible nitric oxide synthase expression, which consequently reduced the nitric oxide level in the liver. Alterations in the gut microbiota due to an increase in the populations of the Bacteroides and Akkermansia genera by the coconut water vinegar may have helped to overcome the obesity and inflammation caused by the HFD. These results provide valuable insights into coconut water vinegar as a potential food ingredient with anti-obesity and anti-inflammatory effects.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice

Mohamad

Yeap

Kỳ

et al. 2017

Food & Nutrition Research

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“…Although the natural products betulin and prunetin, which suppress SREBP actions, have been reported to improve diet-induced obesity in animal models (Tang et al, 2011;Ahn et al, 2013), more antiobesity agents that are safe, effective, and well characterized are needed. Our study screened a library of natural products and identified andrographolide, an active and important labdane diterpenoid separated from rhizomes of Andrographis paniculata, as significantly opposing SREBPs signaling.…”

Section: Introductionmentioning

confidence: 99%

Andrographolide Prevents High-Fat Diet–Induced Obesity in C57BL/6 Mice by Suppressing the Sterol Regulatory Element-Binding Protein Pathway

Ding

Song

et al. 2014

J Pharmacol Exp Ther

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Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the expression of genes involved in biosynthesis of cholesterol, fatty acids, and triglycerides. We investigated the effect of the specific SREBP suppressor andrographolide, a natural compound isolated from Andrographis paniculata, on the regulation of SREBP signaling by use of Western blot, reporter gene assay, and quantitative real-time polymerase chain reaction analysis. In addition, the antiobesity effects of andrographolide were evaluated in C57BL/6 mice with high-fat diet (HFD)-induced obesity. Our results showed that andrographolide downregulated the expressions of SREBPs target genes and decreased cellular lipid accumulation in vitro. Further, andrographolide (100 mg/kg per day) attenuated HFD-induced body weight gain and fat accumulation in liver or adipose tissues, and improved serum lipid levels and insulin or glucose sensitivity in HFD-induced obese mice. Andrographolide effectively suppressed the respiratory quotient, energy expenditure, and oxygen consumption, which may have contributed to the decreased body-weight gain of the obese mice fed with a HFD. Consistently, andrographolide regulated SREBP target genes and metabolism-associated genes in liver or brown adipose tissue, which may have directly contributed to the lower lipid levels and enhanced insulin sensitivity. Taken together, our results indicated that andrographolide ameliorated lipid metabolism and improved glucose use in mice with HFD-induced obesity. Andrographolide has potential as a leading compound in the prevention or treatment of obesity and insulin resistance.

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An Insight Review on Phytochemistry, Pharmacological Evidences, and Biosynthesis of Key Metabolites of Indian Himalayan Cherry (Prunus cerasoides Don.) with Emphasis on its Safety and Use in Tradtional Phytomedicine

Jyotshna,

Shanker

2024

Chemistry & Biodiversity

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Padmaka (Prunus cerasoides Don.), or wild Himalayan cherry, is a deciduous tree from the Rosaceaae family. The Prunus genus has 400–430 species, including shrubs and trees. It is widely distributed across the Himalayan region of India, China, Myanmar, Nepal, and Thailand. It is used in many classical formulations of various Asian traditional medicinal systems viz., Ayurveda, TCM (traditional Chineese Medicines) and TTM (Traditional Thai Medicines) for treating burning sensations, Blisters, blood disorders, dizziness, bleeding disorders, herps, and skin disorders. The present review covers the research updates on P. cerasoides from 1982 to 2023, accessible on scholars’ platforms and databases. More than 200 phytomolecules have been investigated for their biological potential and the discovery of pharmacophores‐inspired drugs. Padmaka instigated over fifty diverse phytochemicals, viz. flavones, isoflavones, chalcones, terpenoids, glycosides, and sterols. The phytochemical flux of P. cerasoides is dominant with phenylpropanoids, anthocyanins, carotenoids, and terpenoids. Several experimental shreds of evidence emphasized the biological significance of P. cerasoides extracts and their derived phytochemicals. Medicinal significance and its safety in clinical validation have been discussed efficiently. Moreover, the barrier in validated therapeutics is a lack of information on the bioavailability of specialized bioactive, standardization, safety, and toxicokinetic. This review also provides insight into discussions on the key specialized secondary metabolism in P. cerasoides responsible for pharmacological/therapeutic action.

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Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone

Cited by 52 publications

References 43 publications

Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice

Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice

Andrographolide Prevents High-Fat Diet–Induced Obesity in C57BL/6 Mice by Suppressing the Sterol Regulatory Element-Binding Protein Pathway

An Insight Review on Phytochemistry, Pharmacological Evidences, and Biosynthesis of Key Metabolites of Indian Himalayan Cherry (Prunus cerasoides Don.) with Emphasis on its Safety and Use in Tradtional Phytomedicine

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