Molecular mechanisms underlying the role of TRP channels in chemesthesis

Alpízar, Yeranddy A.; Voets, Thomas; Talavera, Karel

doi:10.1002/9781118951620.ch4

Cited by 4 publications

(2 citation statements)

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“…Several TRP channels were first described as receptors sensitive to temperature changes and pungent or cooling spices. These channels function as molecular sensors for specific chemical entities, among which are painful toxins, playing a role in chemesthesis [16,17,18]. For example, capsaicin, a component of hot peppers, is a potent agonist of the TRP vanilloid 1 (TRPV1) channel [19,20].…”

Section: Introductionmentioning

confidence: 99%

Transient Receptor Potential Channels in Intestinal Inflammation: What Is the Impact of Cigarette Smoking?

Allais

Smet²,

Verschuere³

et al. 2016

Pathobiology

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Inflammatory bowel disease (IBD) is characterized by severe gastrointestinal inflammation and results from a complex interplay between genetic and environmental factors. IBD includes two prominent subtypes: Crohn's disease (CD) and ulcerative colitis (UC). One of the main risk factors for the development of CD is cigarette smoking, while UC is rather a disease of ex-smokers. To date, many of the mechanisms underlying the immune imbalance in IBD and the involvement of cigarette smoke (CS) are incompletely understood. Transient receptor potential (TRP) proteins are non-selective cation channels that, upon activation, lead to plasma membrane depolarization and, in general, to Ca²⁺ influx. TRP channels of the ankyrin and vanilloid family, expressed by sensory neurons in the central and enteric nervous systems, have been extensively studied in the context of intestinal inflammation. Moreover, recent advances made on the role of non-neuronal expressed TRP channels shed light on the involvement of epithelial cells in inflammatory processes. This review focuses on how CS may impact TRP channel function in intestinal inflammation. Firstly, we discuss the current knowledge on neuronal TRP channels, known to be linked to IBD, in health, immune homeostasis and intestinal inflammation. Subsequently, we address how TRP channels are activated by CS and its components in other organ systems and also hypothesize on the potential implications for CS-mediated TRP channel activation in gut inflammation.

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Section: Introductionmentioning

confidence: 99%

Transient Receptor Potential Channels in Intestinal Inflammation: What Is the Impact of Cigarette Smoking?

Allais

Smet²,

Verschuere³

et al. 2016

Pathobiology

Self Cite

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“…), use of commercial jellybeans here limits interpretation somewhat. That is, cinnamon flavored candies presumably contain cinnamaldehyde, a well-known TRPA1 agonist [69,70].However, we cannot rule out whether they contain capsaicin (or another TRPV1 agonist), as food labeling laws in the United States allow manufacturers to declare such ingredients as natural or artificial flavors on the package without being more specific, so we cannot make strong inferences about which specific chemesthetic mechanisms might be affected by SARS-CoV-2 infection. Nonetheless, present data extend prior work by clearly showing oral burn can be transiently affected by COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Transient loss and recovery of oral chemesthesis, taste and smell with COVID-19: a small case-control series

Weir

Exten

Gerkin

et al. 2023

Preprint

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Anosmia is common with respiratory virus infections, but loss of taste or chemesthesis is rare. Reports of true taste loss with COVID-19 were viewed skeptically until confirmed by multiple studies. Nasal menthol thresholds are elevated in some with prior COVID-19 infections, but data on oral chemesthesis are lacking. Many patients recover quickly, but precise timing and synchrony of recovery are unclear. Here, we collected broad sensory measures over 28 days, recruiting adults (18-45 years) who were COVID-19 positive or recently exposed (close contacts per U.S. CDC criteria at the time of the study) in the first half of 2021. Participants received nose clips, red commercial jellybeans (Sour Cherry and Cinnamon), and scratch-n-sniff cards (ScentCheckPro). Among COVID-19 cases who entered the study on or before Day 10 of infection, Gaussian Process Regression showed odor identification and odor intensity (two distinct measures of function) each declined relative to controls (close contacts who never developed COVID-19), but effects were larger for intensity than identification. To assess changes during early onset, we identified four COVID-19 cases who enrolled on or prior to Day 1 of their illness: this allowed for visualization of baseline ratings, loss, and recovery of function over time. Four controls were matched for age, gender, and race. Variables included sourness and sweetness (Sour Cherry jellybeans), oral burn (Cinnamon jellybeans), mean orthonasal intensity of four odors (ScentCheckPro), and perceived nasal blockage. Data were plotted over 28 days, creating panel plots for the eight cases and controls. Controls exhibited stable ratings over time. By contrast, COVID-19 cases showed sharp deviations over time. No single pattern of taste loss or recovery was apparent, implying different taste qualities might recover at different rates. Oral burn was transiently reduced for some before recovering quickly, suggesting acute loss may be missed in data collected after acute illness ends. Changes in odor intensity or odor identification were not explained by nasal blockage. Collectively, intensive daily testing shows orthonasal smell, oral chemesthesis and taste were each altered by acute COVID-19 infection, and this disruption was dyssynchronous for different modalities, with variable loss and recovery rates across modalities and individuals.

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Physiology of Sensory Perception of Flavour and Mouthfeel Stimuli Imparted by Dairy Products

Methven¹,

Lignou²,

Bull³

et al. 2023

Sensory Profiling of Dairy Products

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Molecular mechanisms underlying the role of TRP channels in chemesthesis

Cited by 4 publications

References 129 publications

Transient Receptor Potential Channels in Intestinal Inflammation: What Is the Impact of Cigarette Smoking?

Transient Receptor Potential Channels in Intestinal Inflammation: What Is the Impact of Cigarette Smoking?

Transient loss and recovery of oral chemesthesis, taste and smell with COVID-19: a small case-control series

Physiology of Sensory Perception of Flavour and Mouthfeel Stimuli Imparted by Dairy Products

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