Molecular mimicry: An explanation for autoimmune diseases and infertility

Thaper, Deepali; Prabha, Vijay

doi:10.1111/sji.12697

Cited by 24 publications

(18 citation statements)

References 91 publications

(133 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the duration of infertility and the type of infertility increase the risk of STDs by increasing risky sexual behavior [42] [43] [44] and STDs are responsible for the production of ASA by antigenic community with the spermatozoa or by destruction of the blood-testicular barrier [45] [46], we found no association between the duration of infertility in men and ACAS positivity. Unlike us, Tennakoon V [47] found the association.…”

Section: Discussioncontrasting

confidence: 62%

Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo

Mike-Antoine¹,

Sihalikyolo²,

Agasa³

et al. 2019

OJOG

View full text Add to dashboard Cite

Introduction: Antisperm antibodies (ASA) prevalence is high in Kisangani. ASA are one of the male factors of infertility that can reduce spermatozoa motility and cervical penetration or prevent acrosomal reaction and even alter embryo development. This study aims to determine the risk factors of ASA positivity among infertile men in Kisangani. Patient and Method: We conducted a case-control study during a period of 2 years in Kisangani on 111 men who consulted for conception and tested for ASA by ELISA. We did a simple pairing that concerned only the type of infertility. For a better balance between the number of cases and controls per stratum to provide better accuracy in the adjusted OR estimate, we performed a 1:1 match. Results: This study showed that businessmen [ORa = 5.0000(1.2452 − 20.0767)] and jobless [ORa = 5.8125(1.1477 − 29.4367)] were at risk of being positive for ASA. Violent blow to testicles [ORa = 6.7391(1.3455 − 33.7545)], cure of hernia [ORa = 4.3478(1.0722 − 17.6299)], Chlamydia infection [ORa = 4.7125(1.3405 − 16.5665)], leucospermia [ORa = 4.1429(1.0406 − 19.7155)]and presence of Staphylococcus aureus ] were associated to positive ASA. Conclusion: This study shows that factors that may lead to risky sexual behavior and physical or infectious trauma are important risk factors for ASA positivity. It is therefore necessary to search for them systematically during male infertility in order to guide the search for ASA.

show abstract

Section: Discussioncontrasting

confidence: 62%

Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo

Mike-Antoine¹,

Sihalikyolo²,

Agasa³

et al. 2019

OJOG

View full text Add to dashboard Cite

show abstract

“…To date, different molecular mechanisms have been reported to play a role in autoimmune processes, such as pathogen/host interaction, and molecular mimicry [ 52 , 53 ]. Moreover, it has also been shown that cross-reactive Abs produced in the context of microbial infections have the potential to cause damage to host tissues [ 54 , 55 ].…”

Section: Ra Immunopathogenesismentioning

confidence: 99%

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Jasemi

Uras

et al. 2020

Microorganisms

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic erosive polyarthritis. A complex interaction between a favorable genetic background, and the presence of a specific immune response against a broad-spectrum of environmental factors seems to play a role in determining susceptibility to RA. Among different pathogens, mycobacteria (including Mycobacterium avium subspecies paratuberculosis, MAP), and Epstein–Barr virus (EBV), have extensively been proposed to promote specific cellular and humoral response in susceptible individuals, by activating pathways linked to RA development. In this review, we discuss the available experimental and clinical evidence on the interplay between mycobacterial and EBV infections, and the development of the immune dysregulation in RA.

show abstract

“…The immune reaction in spermatozoa causes 2-30% of infertility (34) and in 9-12.8% of infertile couples were found anti-sperm antibodies (35,36). Affected women of bacterial vaginitis caused by Staphylococcus aureus develop antibodies against S. aureus that cross-react with human spermatozoa proteins which could be a potential cause of infertility (37). A molecular modeling approach revealed 55 of 96 human spermatozoa proteins with homology to S. aureus proteins (identity 19-45%).…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Bacterial molecular mimicry in autoimmune diseases

Palma

2021

Curr Biosci

View full text Add to dashboard Cite

Bacterial molecular mimicry in autoimmune diseases is one of the leading mechanisms by which microorganisms may induce autoimmunity and survive in the host. The main purpose of the current study was to determine the main microbes that elicit autoimmune reactions through molecular mimicry and identify the most relevant approaches to investigate this mechanism. A classic example is the M protein of Streptococcus pyogenes, which induces antibody cross-reactivity with a cardiac protein and causes rheumatic fever. Another notable example is the protein from Porphyromonas gingivalis that closely resembles the human heat shock protein and accelerates atherosclerotic. There is evidence that antibodies against Helicobacter pylori CagA interact with different parts of smooth muscle and endothelial cells enhancing atherosclerotic vascular disease. Recently, one cause of infertility has been associated with Staphylococcus aureus molecular mimicry that triggers an antibody response that cross-reacts with human spermatozoa proteins. Further examples of bacterial molecular mimicry are associated with Chlamydia pneumoniae, Escherichia coli, Yersinia, and Salmonella. From the literature, the most widely used methods in this field are Basic Local Alignment Search Tool (BLAST), serological assays, and phage display. The subjects of particular concern are vaccine cross-reactivity and immunosuppressive drugs side-effects, therefore alternative approaches are needed. Such an approach is phage display where therapeutic antibody fragments obtained by this technique have been used in the treatment of autoimmune diseases by neutralizing the pathological effects of autoantibodies. Phage display libraries are constructed from the antibody repertoires of autoimmune disease patients. Antibody fragments without the Fc domain can not interact with Fc receptors and proteins of the complement system and trigger autoimmune diseases. Another approach is to block the Fc receptors. In conclusion, this review highlights key aspects of bacterial molecular mimicry to better understand the factors associated with autoimmune diseases and encourage further research in this field.

show abstract

Molecular mimicry: An explanation for autoimmune diseases and infertility

Cited by 24 publications

References 91 publications

Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo

Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Bacterial molecular mimicry in autoimmune diseases

Contact Info

Product

Resources

About