Molecular monolayers on silicon as substrates for biosensors

Touahir, Larbi; Allongue, P.; Aureau, Damien; Boukherroub, Rabah; Chazalviel, J.‐N.; Galopin, Élisabeth; Gouget-Laemmel, Anne Chantal; Villeneuve, Catherine Henry de; Moraillon, A.; Niedziółka‐Jönsson, Joanna; Ozanam, F.; Andresa, Juliana Salvador; Sam, S.; Solomon, I.; Szunerits, Sabine

doi:10.1016/j.bioelechem.2010.03.011

Cited by 35 publications

(31 citation statements)

References 32 publications

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“…Chemically modified surfaces were already the subject of many studies in the last decades since they find application in numerous areas including electrocatalysis, [114] [115] corrosion protection, [116] molecular electronics, [117] [118] integrated circuits, [119] [120] information storage, [120]- [122] sensing [123] [124] and many others.…”

Section: Surface Modificationmentioning

confidence: 99%

Shape‐Switchable Azo‐Macrocycles

et al. 2009

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The synthesis of four shape‐switchable macrocycles comprising different peripheral substituents is described. The macrocycles 1–4 consist of m‐terphenyl semicircles interlinked by two azo joints. These macrocycles were assembled from nitro‐functionalized m‐terphenyl moieties through reductive dimerization. The semicircles were assembled through Suzuki cross‐coupling reactions. The molecular weights of the macrocycles were determined by vapour pressure osmometry, because mass spectrometry failed in the cases of 2 and 3. The E → Z photoisomerization reactions were analysed by UV/Vis spectroscopy complemented by 1H NMR studies. A very slow thermal back‐reaction indicated considerable stabilization of the Z isomer. The reduced efficiency of the thermal back‐reaction probably arises from the reduced degree of freedom due to the mechanical interlinking of the two azo groups. The photostationary state consisted of all‐Z (85 %) and all‐E isomers (15 %). The E → Z transformation induced by irradiation displayed simple exponential kinetics, which indicates pairwise switching of the two azo groups in a macrocycle, at least on the timescale under investigation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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Section: Surface Modificationmentioning

confidence: 99%

Shape‐Switchable Azo‐Macrocycles

et al. 2009

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“…[13][14] Methyl termination of Si(111) surfaces (CH 3 -Si(111)) by a wet-chemical process yields atomically flat Si with all surface Si sites terminated. [15][16][17][18] Although CH 3 -Si(111) surfaces exhibit enhanced resistance to air oxidation compared to H-Si(111) surfaces, [19][20] -CH 3 groups are limited by a lack of methods to impart secondary functionalization.…”

Section: Introductionmentioning

confidence: 99%

Vibrational Sum-Frequency Spectroscopic Investigation of the Structure and Azimuthal Anisotropy of Propynyl-Terminated Si(111) Surfaces

et al. 2017

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Vibrational sum-frequency generation (VSFG) spectroscopy was used to investigate the orientation and azimuthal anisotropy of the C-H stretching modes for propynyl-terminated Si(111) surfaces, Si-C≡C-CH 3 . VSFG spectra revealed symmetric and asymmetric C-H stretching modes in addition to a Fermi resonance mode resulting from the interaction of the asymmetric C-H bending overtone with the symmetric C-H stretching vibration. The polarization dependence of the C-H stretching modes was consistent with the propynyl groups oriented such that the Si-C≡C bond is normal to the Si(111) surface. The azimuthal angle dependence of the resonant C-H stretching amplitude revealed no rotational anisotropy for the symmetric C-H stretching mode and a 3-fold rotational anisotropy for the asymmetric C-H stretching mode in registry with the 3-fold symmetric Si(111) substrate. The results are consistent with expectation that the C-H stretching modes of a -CH 3 group are decoupled from the Si substrate due to a -C≡C-spacer. In contrast, the methyl-terminated Si(111) surface, Si-CH 3 , was previously reported to have pronounced vibronic coupling of the methyl stretch modes to the electronic bath of bulk Si. Vacuum-annealing of propynyl-terminated Si(111) resulted in increased 3-fold azimuthal anisotropy for the symmetric stretch, suggesting that removal of

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“…For sensor applications, non-specific adsorption of the target molecules on the hydrophobic surface is a problem, which may be avoided if the alkene chains are modified by attachment of hydrophilic ethyleneoxide oligomers at their end (177). Though the organic coating does not rigorously exclude silicon oxidation on the long term, the protection is sufficient to guarantee perfect stability, reproducibility and reusability of these sensors on a time scale of several months (175). …”

Section: Modifying the Grafted Layer: Toward Sensor Applicationsmentioning

confidence: 99%

(Allesandro Volta Award Presentation) Facts and Challenges in the Electrochemistry and Wet Surface Chemistry of Silicon

Chazalviel¹

2013

ECS Trans.

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Silica being insoluble in non-fluoride medium, anodic oxide films are readily formed on silicon. Dissolution of any oxide film in HF leaves a surface covered with hydrogen. Anodization in HF leads to the formation of porous silicon, the hydrogen coating staying present during the process. At higher potentials, electropolishing is observed, with the presence of a thin oxide layer on the surface. At still higher potentials, mesoporous oxide films are obtained. In non-aqueous media, trace amounts of water unavoidably lead to irreversible formation of a silica layer. In methanol a more stable behavior is obtained, due to chemical surface modification by grafting of methoxy groups. Other modifications of the silicon surface include the formation of covalent Si-C bonds, which holds promises for applications, especially sensors. In the near future, challenges in silicon electrochemistry include a better understanding of several fundamental issues, and also improved preservation of the surface against oxidation.

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Molecular monolayers on silicon as substrates for biosensors

Cited by 35 publications

References 32 publications

Shape‐Switchable Azo‐Macrocycles

Shape‐Switchable Azo‐Macrocycles

Vibrational Sum-Frequency Spectroscopic Investigation of the Structure and Azimuthal Anisotropy of Propynyl-Terminated Si(111) Surfaces

(Allesandro Volta Award Presentation) Facts and Challenges in the Electrochemistry and Wet Surface Chemistry of Silicon

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