Molecular Motor‐Driven Light‐Controlled Logic‐Gated K⁺ Channel for Cancer Cell Apoptosis

Abstract

Developing artificial ion transport systems, which process complicated information and step‐wise regulate properties, is essential for deeply comprehending the subtle dynamic behaviors of natural channel proteins (NCPs). Here we report a photo‐controlled logic‐gated K+ channel based on single‐chain random heteropolymers (RHPs) containing molecular motors, exhibiting multi‐core processor‐like properties to step‐wise control ion transport. Designed with oxygen, deoxygenation, and different wavelengths of light as input signals, complicated logical circuits comprising “YES”, “AND”, “OR” and “NOT” gate components are established. Implementing these logical circuits with K+ transport efficiencies as output signals, we realize multiple state transitions including “ON”, “Partially OFF” and “Totally OFF” in liposomes and cancer cells, further causing step‐wise anticancer treatments. Dramatic K+ efflux in “ON” state (decrease by 50% within 7 minutes) significantly induces cancer cell apoptosis. We expect this integrated logic‐gated strategy will be expanded toward understanding the delicate mechanism underlying NCPs and treating cancer or other diseases.This article is protected by copyright. All rights reserved