Molecular Networks in Melanoma Invasion and Metastasis

Aładowicz, Ewa; Ferro, Leda; Vitali, Giulio Cesare; Venditti, Elisabetta; Fornasari, Lorenzo; Lanfrancone, Luisa

doi:10.2217/fon.13.9

Cited by 43 publications

(32 citation statements)

References 121 publications

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“…These results suggested that melanocyte migration in the BF might affect B-cell development. Malignant neoplasms of human skin (melanomas) exhibit atypical migration of melanocytes in the lymph nodes1920; therefore, the BF acts as an immune organ that provides the material needed to investigate the effects of melanocytes on the development of B-cells in an ideal environment.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analyses of differential gene expression in the bursa of Fabricius between Silky Fowl and White Leghorn

Han

Zhang

Chen

et al. 2017

Sci Rep

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Hyperpigmentation in Silky Fowl (SF) results in aberrant immune cell development. However, how melanocytes regulate B-cell proliferation in the bursa of Fabricius (BF) is unclear. To resolve this conundrum, we collected BFs from three-week-old SF and White Leghorn (WL) female chickens for RNA sequencing. The BF development was relatively weaker in SF than in WL. The transcriptome analyses identified 4848 differentially expressed genes, 326 long noncoding RNAs (lncRNAs), and 67 microRNAs in the BF of SF. The genes associated with melanogenesis was significantly higher, but that of the genes associated with the cytokine-cytokine receptor interactions and JAK-STAT signalling pathway was significantly lower in SF than in WL. Crucial biological processes, such as the receptor activity, cell communication, and cellular responses to stimuli, were clustered in SF. The predicted target lncRNAs genes were mainly associated with cell proliferation pathways such as JAK-STAT, WNT, MAPK, and Notch signalling pathways. Except for the above pathways, the target microRNA genes were related to the metabolism, melanogenesis, autophagy, and NOD-like and Toll-like receptor signalling pathways. The lncRNAs and microRNAs were predicted to regulate the JAK2, STAT3, and IL-15 genes. Thus, B-cell development in the BF of SF might be regulated and affected by noncoding RNAs.

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Section: Discussionmentioning

confidence: 99%

Transcriptome analyses of differential gene expression in the bursa of Fabricius between Silky Fowl and White Leghorn

Han

Zhang

Chen

et al. 2017

Sci Rep

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“…It is characterized by a bad prognosis for aggressive invasion and high drug resistance [1]. Invasion gives melanoma cells the ability to break out of tissue compartments and spread locally.…”

Section: Introductionmentioning

confidence: 99%

Wogonin Suppresses Melanoma Cell B16-F10 Invasion and Migration by Inhibiting Ras-Medicated Pathways

et al. 2014

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The patients diagnosed with melanoma have a bad prognosis for early regional invasion and distant metastases. Wogonin (5,7-dihydroxy-8-methoxyflavone) is one of the active components of flavonoids that extracts from Scutellariae radix. Several previous studies reported that wogonin possesses antitumor effect against leukemia, gastrointestinal cancer and breast cancer. In this study, we used melanoma cell B16-F10 to further investigate the anti-invasive and anti-migratory activity of wogonin. Our date showed that wogonin caused suppression of cell migration, adhesion, invasion and actin remodeling by inhibiting the expression of matrix metalloproteinase-2 and Rac1 in vitro. Wogonin also reduced the number of the tumor nodules on the whole surface of the lung in vivo. Furthermore, the examination of mechanism revealed that wogonin inhibited Extracellular Regulated protein Kinases and Protein Kinase B pathways, which are both medicated by Ras. Insulin-like growth factor-1-induced or tumor necrosis factor-α-induced invasion was also inhibited by wogonin. Therefore, the inhibitory mechanism of melanoma cell invasion by wogonin might be elucidated.

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“…Melanoma invasion and metastasis are accompanied by changes in cell morphology and the activation of mechanisms that confer the capability of cell movement (Aladowicz et al, 2013). The networks constructed for target genes of continuously up-regulated or downregulated miRNAs were associated with cell morphology, cell development, DNA replication, and system development.…”

Section: Network Related To Cell Morphology Cell Development and Cementioning

confidence: 99%

Deep sequencing analysis of microRNA expression in human melanocyte and melanoma cell lines

Ding

Wang

Yang

et al. 2015

Gene

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Molecular Networks in Melanoma Invasion and Metastasis

Cited by 43 publications

References 121 publications

Transcriptome analyses of differential gene expression in the bursa of Fabricius between Silky Fowl and White Leghorn

Transcriptome analyses of differential gene expression in the bursa of Fabricius between Silky Fowl and White Leghorn

Wogonin Suppresses Melanoma Cell B16-F10 Invasion and Migration by Inhibiting Ras-Medicated Pathways

Deep sequencing analysis of microRNA expression in human melanocyte and melanoma cell lines

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