Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis

Roubinet, Chantal; Decelle, Barbara; Chicanne, Gaëtan; Dorn, Jonas F.; Payrastre, Bernard; Payre, François; Carréno, Sébastien

doi:10.1083/jcb.201106048

Cited by 83 publications

(135 citation statements)

References 55 publications

Supporting

Mentioning

131

Contrasting

Order By: Relevance

“…In doing so, it facilitates spindle assembly [19,20]. At anaphase, Moesin is then deactivated at the poles by the phosphatase PP1 to induce local cortical softening to allow anaphase elongation and cell division [14,25]. At the same time, isotropic active Ect2 is relocated to the spindle midzone, where it concentrates RhoA-GTP, to drive furrowing [26].…”

Section: Ect2 and Erm Proteins In Mitotic Rounding And Cancer Metastasismentioning

confidence: 99%

The metastatic cancer cell cortex: An adaptation to enhance robust cell division in novel environments?

Matthews¹,

Baum²

2012

BioEssays

View full text Add to dashboard Cite

Section: Ect2 and Erm Proteins In Mitotic Rounding And Cancer Metastasismentioning

confidence: 99%

The metastatic cancer cell cortex: An adaptation to enhance robust cell division in novel environments?

Matthews¹,

Baum²

2012

BioEssays

View full text Add to dashboard Cite

“…However, their role in epithelial cell cytokinesis remains unknown, and it is unclear, for example, whether apical-basal segregation of PtdIns(4,5)P 2 and PtdIns(3,4,5)P 3 is preserved during epithelial cell mitosis. It is well established that, in Schizosaccharomyces pombe (Zhang et al, 2000), Drosophila S2 cells (Ben El Kadhi et al, 2011;Roubinet et al, 2011) and isolated mammalian cells (Abe et al, 2012;Dambournet et al, 2011;Emoto et al, 2005;Field et al, 2005;Kouranti et al, 2006), PtdIns(4,5)P 2 is the only phosphoinositide that is obviously enriched at the plasma membrane of the cleavage furrow. There, PtdIns(4,5)P 2 is essential for the recruitment of anillin (also known as ANLN in mammals and Scraps in Drosophila), which then interacts with components of the actin cytoskeleton, including F-actin, Myo II, RhoA, Ect2 [a guanine nucleotide exchange factor (GEF) for Rho GTPases] and septins (Box 1; Fig.…”

Section: Maintenance Of Polarity During Epithelial Cytokinesis?mentioning

confidence: 99%

Epithelial cell division – multiplying without losing touch

Bras

Borgne

2014

Journal of Cell Science

View full text Add to dashboard Cite

Epithelia are compact tissues comprising juxtaposed cells that function as mechanical and chemical barriers between the body and the environment. This barrier relies, in part, on adhesive contacts within adherens junctions, which are formed and stabilized by Ecadherin and catenin proteins linked to the actomyosin cytoskeleton. During development and throughout adult life, epithelia are continuously growing or regenerating, largely as a result of cell division. Although persistence of adherens junctions is needed for epithelial integrity, these junctions are continually remodelled during cell division. In this Commentary, we will focus on cytokinesis, the final step of mitosis, a multiparty phenomenon in which the adherens junction belt plays an essential role and during which a new cell-cell interface is generated between daughter cells. This new interface is the site of intense remodelling, where new adhesive contacts are assembled and cell polarity is transmitted from mother to daughter cells, ultimately becoming the site of cell signalling.

show abstract

“…ERMs harboring phosphomimetic or non-phosphorylatable residues are often used as dominant 'active' and 'inactive' proteins. However, recent studies have revealed that dephosphorylation of this site is important in many contexts, and in some cases, a cycle of phosphorylation and de-phosphorylation is actually essential to ERM activity (Kunda et al, 2012;Roubinet et al, 2011;Viswanatha et al, 2012). Such 'phosphocycling' of ezrin has recently been shown to be necessary for the formation of apical microvilli (Viswanatha et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

ERM proteins at a glance

McClatchey

2014

Journal of Cell Science

View full text Add to dashboard Cite

The cell cortex is a dynamic and heterogeneous structure that governs cell identity and behavior. The ERM proteins (ezrin, radixin and moesin) are major architects of the cell cortex, and they link plasma membrane phospholipids and proteins to the underlying cortical actin cytoskeleton. Recent studies in several model systems have uncovered surprisingly dynamic and complex molecular activities of the ERM proteins and have provided new mechanistic insight into how they build and maintain cortical domains. Among many well-established and essential functions of ERM proteins, this Cell Science at a Glance article and accompanying poster will focus on the role of ERMs in organizing the cell cortex during cell division and apical morphogenesis. These examples highlight an emerging appreciation that the ERM proteins both locally alter the mechanical properties of the cell cortex, and control the spatial distribution and activity of key membrane complexes, establishing the ERM proteins as a nexus for the physical and functional organization of the cell cortex and making it clear that they are much more than scaffolds.This article is part of a Minifocus on Establishing polarity. For further reading, please see related articles: 'Establishment of epithelial polarity -GEF who's minding the GAP?' by Siu Ngok et al. (J. Cell Sci. 127,(3205)(3206)(3207)(3208)(3209)(3210)(3211)(3212)(3213)(3214)(3215). 'Integrins and epithelial cell polarity' by Jessica Lee and Charles Streuli (J. Cell Sci. 127, 3217-3225).

show abstract

Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis

Abstract: During mitosis, cortical Moesin activity is restricted to promote cell elongation and cytokinesis, but localized Moesin recruitment is necessary for polar bleb retraction and cortical relaxation.

Cited by 83 publications

References 55 publications

The metastatic cancer cell cortex: An adaptation to enhance robust cell division in novel environments?

The metastatic cancer cell cortex: An adaptation to enhance robust cell division in novel environments?

Epithelial cell division – multiplying without losing touch

ERM proteins at a glance

Contact Info

Product

Resources

About