Molecular nutrition: basic understanding of the digestion, absorption, and metabolism of nutrients

Yan, Xianghua

doi:10.1631/jzus.b1500130

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…Similar effects of different lactation stages on milk exosome proteome have been previously reported in bovines (SAMUEL et al, 2017), albeit not yet studied in porcine, nor on the exosomal lipid composition of any species. Similarly, while the diet is an important external factor in many molecular processes (YAN, 2015;NASIR et al, 2020), its impact on exosome composition has hardly been investigated so far.…”

Section: Discussionmentioning

confidence: 99%

“…The use of ω-3 PUFA enriched diets has also been associated with an overall reduction in milk fat percentage of dairy cows (MOALLEM, 2018;MUSTAFA et al, 2003;DONOVAN et al, 2000), although no changes in milk protein (MOALLEM, 2018;MUSTAFA et al, 2003;AKRAIM et al, 2007) or milk lactose (DONOVAN et al, 2000;MOALLEM et al, 2013;GONTHIER et al, 2005) percentages have been found, and reports on the milk EV fraction were unavailable until now. While the diet is an important external factor in many molecular processes (YAN, 2015;NASIR et al, 2020), its impact on exosome composition has hardly been investigated so far. Thus, this study aims to bridge this gap by providing knowledge on how the lipid and protein composition of porcine milk exosomes may be affected by different ratios of PUFA in the diet.…”

Section: Figure 1xosome Biogenesis With Main Molecules Shown To Affec...mentioning

confidence: 99%

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Comparative proteome profiling in exosomes derived from porcine colostrum versus mature milk reveals distinct functional proteomes

Ferreira

Blees

Shakeri

et al. 2021

Journal of Proteomics

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Section: Discussionmentioning

confidence: 99%

Section: Figure 1xosome Biogenesis With Main Molecules Shown To Affec...mentioning

confidence: 99%

Comparative proteome profiling in exosomes derived from porcine colostrum versus mature milk reveals distinct functional proteomes

Ferreira

Blees

Shakeri

et al. 2021

Journal of Proteomics

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“…With the development of molecular biology, nutriology and genetics, it is gradually recognized that, to reveal the metabolic mechanism of nutrients in aquatic animals, it is necessary to study the regulation mechanism of key metabolic enzymes (Kore, Pathak, & Gadekar, ; Rezzi, Collino, Goulet, & Martin, ; Yan, ). In recent years, more and more animal genes related to nutrient metabolism have been cloned and identified.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome, enzyme activity and histopathology analysis reveal the effects of high level of dietary carbohydrate on glycometabolism in juvenile golden pompano,Trachinotus ovatus

Liu

Tan

et al. 2019

Aquac Res

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Golden pompano (Trachinotus ovatus) is an important aquaculture species in Chinaand broadly cultivated in Asia-Pacific region. Our previous study found that T. ovatus had a better tolerance to the high level of carbohydrate in diet (360 g/kg) compared to Micropterus salmoides. Present study investigated the tolerance mechanism of T. ovatus to high level of dietary carbohydrate (PH-360 g/kg of corn starch) on transcriptome level using Illumina sequencing compared to optimum level of dietary carbohydrate (PM-240 g/kg corn starch). A total of 208,952,492 reads were obtained and assembled into 62,377 unigenes with an average length of 822 bp and a range of 200-16,206 bp. Transcriptome annotation revealed that 27,636 unigenes with a cut-off e-value of 10 −5 were functionally annotated. Specifically, 7,903 unigenes were clustered into 24 functional categories by searching against the COG database, 12,161 unigenes to 84 GO terms, 26,835 unigenes to Nr database and 23,681 unigenes to SWISS-PROT database. In addition, 13,739 unigenes were grouped into 240 KEGG pathways. There are 3,461 differentially expressed genes in PH compared to PM, in which 3,059 unigenes were significantly upregulated and 402 unigenes were significantly downregulated. Twelve key genes related to carbohydrate metabolism were further validated by quantitative real-time RT-PCR, and the results were consistent with those of transcriptome profile. Under high level of dietary carbohydrate (PH-360 g/kg), the results indicate that T. ovatus can adapt to the high level of carbohydrate in diet by enhancing glycolysis with hepatic HK enzyme activity was significantly increased (p > 0.05), reducing gluconeogenesis with the decreased trend of PEPCK enzyme activity and maintaining the homeostasis of carbohydrate metabolism-related hormones and hormone receptor gene expressions. Histopathological examination has shown that liver cavity area was significantly increased (p > 0.05), but no visible nutritional diseases are found in fish. This study provides a valuable understanding of the molecular responses of T. ovatus fed by the high level of dietary carbohydrate (PH-360 g/kg).

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“…A high-density caged environment is one of the most common and economical systems employed by the commercial layer industry (Davis et al, 2000). Associated with the economic success of this system are a number of health problems, including renomegaly, hepatic lipidosis, osteoporosis, cage layer fatigue, ascites, lameness, and inflammation (Burt, 2002;Robins and Phillips, 2011;Buijs et al, 2012;Dai et al, 2015;Yan, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of taurine and housing density on renal function in laying hens

Zhi-gang

Gao

et al. 2016

J. Zhejiang Univ. Sci. B

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This study investigated the putative protective effects of supplemental 2-aminoethane sulfonic acid (taurine) and reduced housing density on renal function in laying hens. We randomly assigned fifteen thousand green-shell laying hens into three groups: a free range group, a low-density caged group, and a high-density caged group. Each group was further divided equally into a control group (C) and a taurine treatment group (T). After 15 d, we analyzed histological changes in kidney cells, inflammatory mediator levels, oxidation and anti-oxidation levels. Experimental data revealed taurine supplementation, and rearing free range or in low-density housing can lessen morphological renal damage, inflammatory mediator levels, and oxidation levels and increase anti-oxidation levels. Our data demonstrate that taurine supplementation and a reduction in housing density can ameliorate renal impairment, increase productivity, enhance health, and promote welfare in laying hens.

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Molecular nutrition: basic understanding of the digestion, absorption, and metabolism of nutrients

Cited by 7 publications

References 23 publications

Comparative proteome profiling in exosomes derived from porcine colostrum versus mature milk reveals distinct functional proteomes

Comparative proteome profiling in exosomes derived from porcine colostrum versus mature milk reveals distinct functional proteomes

Transcriptome, enzyme activity and histopathology analysis reveal the effects of high level of dietary carbohydrate on glycometabolism in juvenile golden pompano,Trachinotus ovatus

Effects of taurine and housing density on renal function in laying hens

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