Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies

Hussain, Ibrahim; Eloy, Jean Anderson; Carmel, Peter W.; Liu, James K.

doi:10.3171/2013.3.jns122214

Cited by 44 publications

(25 citation statements)

References 95 publications

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“…Histologically, these tumors are classified as WHO grade I tumors, and they are subdivided into an adamantinomatous type arising from odontogenic cells (mostly in pediatric patients) or a papillary type arising from buccal mucosa rests (mostly occurring in adults) [3]. Despite their benign histological appearance, their prognosis remains uncertain and may often be unfavorable.…”

Section: Introductionmentioning

confidence: 99%

Giant craniopharyngiomas in children: short- and long-term implications

2015

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Tumor's size has significant impact on the management of CP in children. It affects both short-term factors (initial symptoms, urgency of surgical resection, extent of resection, and perioperative morbidity) as well as long-term parameters (PFS, rate of adjuvant treatments/recurrent surgeries, and metabolic/endocrinal/ophthalmological and functional outcomes). We think that a proper, world-wide accepted definition of what is "large," "giant," or even "monstrous" CP should be established. This will enable carrying multi-institutional studies on a larger group of patients, allowing further determining the importance of tumor's size in the management and outcome of craniopharyngiomas in children.

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Section: Introductionmentioning

confidence: 99%

Giant craniopharyngiomas in children: short- and long-term implications

2015

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“…Several authors have reported high recurrence rates despite apparently complete tumor resection and negative postoperative brain imaging, providing another strong argument for the concept of limited surgery combined with other therapeutic approaches, such as radiotherapy or intracystic catheter placement. 2,3,30,37,42,43,50,62,68,71,78,83,84,89,92,98 The surgical routes used to remove craniopharyngiomas have previously been transcranial approaches, whereas the transsphenoidal approach, in accordance with the indications defined by Guiot and Derome 35 in the early 1960s, was proposed initially for infradiaphragmatic lesions, with an enlarged sella, preferably in patients who had already developed panhypopituitarism. 72 More recently, technological progress and advances in terms of visualization permitted the extension of the microscopic transsphenoidal approach to a variety of suprasellar lesions.…”

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confidence: 99%

The endoscopic endonasal approach for the management of craniopharyngiomas: a series of 103 patients

Cavallo

Günther

Cappabianca

et al. 2014

JNS

202

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Object Despite their benign histological appearance, craniopharyngiomas can be considered a challenge for the neurosurgeon and a possible source of poor prognosis for the patient. With the widespread use of the endoscope in endonasal surgery, this route has been proposed over the past decade as an alternative technique for the removal of craniopharyngiomas. Methods The authors retrospectively analyzed data from a series of 103 patients who underwent the endoscopic endonasal approach at two institutions (Division of Neurosurgery of the Università degli Studi di Napoli Federico II, Naples, Italy, and Division of Neurosurgery of the Bellaria Hospital, Bologna, Italy), between January 1997 and December 2012, for the removal of infra- and/or supradiaphragmatic craniopharyngiomas. Twenty-nine patients (28.2%) had previously been surgically treated. Results The authors achieved overall gross-total removal in 68.9% of the cases: 78.9% in purely infradiaphragmatic lesions and 66.3% in lesions involving the supradiaphragmatic space. Among lesions previously treated surgically, the gross-total removal rate was 62.1%. The overall improvement rate in visual disturbances was 74.7%, whereas worsening occurred in 2.5%. No new postoperative defect was noted. Worsening of the anterior pituitary function was reported in 46.2% of patients overall, and there were 38 new cases (48.1% of 79) of postoperative diabetes insipidus. The most common complication was postoperative CSF leakage; the overall rate was 14.6%, and it diminished to 4% in the last 25 procedures, thanks to improvement in reconstruction techniques. The mortality rate was 1.9%, with a mean follow-up duration of 48 months (range 3–246 months). Conclusions The endoscopic endonasal approach has become a valid surgical technique for the management of craniopharyngiomas. It provides an excellent corridor to infra- and supradiaphragmatic midline craniopharyngiomas, including the management of lesions extending into the third ventricle chamber. Even though indications for this approach are rigorously lesion based, the data in this study confirm its effectiveness in a large patient series.

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“…In particular, clusters of cells with nuclear beta-catenin are predominantly represented in invasive tumors. This pattern is suggestive of an involvement of the beta-catenin signaling in the migratory behavior of these tumors; the cellular clusters with nuclear beta-catenin may coordinate the infiltration of the tumor into surrounding tissues, thus explaining the greater aggressiveness of the adamantinomatous tumor histotype (Hussain et al, 2013;Larkin and Ansorge, 2013).…”

Section: Introductionmentioning

confidence: 92%