2019
DOI: 10.1007/82_2019_170
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Molecular Organization and Assembly of the Export Apparatus of Flagellar Type III Secretion Systems

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Cited by 30 publications
(25 citation statements)
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“…Secreted FlgM is further degraded extracellularly by the proteases Epr and WprA (Calvo and Kearns, 2015). It is currently well known that FliK plays an essential role in switching the substrate specificity of the flagellar export apparatus by modifying the export gate proteins FlhA and FlhB that control flagellar protein export (Aizawa, 2012;Hughes, 2012a,b;Evans et al, 2014;Minamino, 2018;Minamino et al, 2019;Kinoshita et al, 2020). This modification allows specificity switch for the secretion among others of filament class proteins (Ghelardi et al, 2002;Bouillaut et al, 2005;Minamino, 2018).…”
Section: Discussionmentioning
confidence: 99%
“…Secreted FlgM is further degraded extracellularly by the proteases Epr and WprA (Calvo and Kearns, 2015). It is currently well known that FliK plays an essential role in switching the substrate specificity of the flagellar export apparatus by modifying the export gate proteins FlhA and FlhB that control flagellar protein export (Aizawa, 2012;Hughes, 2012a,b;Evans et al, 2014;Minamino, 2018;Minamino et al, 2019;Kinoshita et al, 2020). This modification allows specificity switch for the secretion among others of filament class proteins (Ghelardi et al, 2002;Bouillaut et al, 2005;Minamino, 2018).…”
Section: Discussionmentioning
confidence: 99%
“…The sorting platform also functions as the recognition domain for effectors. It receives them from chaperone proteins and unfolds the effectors for secretion as folded proteins are too large to enter the needle (~2.5 nm inner diameter) [ 39 , 40 , 41 ]. Once the secreted proteins pass into the host cell, they elicit specific responses to reprogram the host’s machinery to enable colonization.…”
Section: Introductionmentioning
confidence: 99%
“…For construction of the flagella on the cell surface, the flagellar type III secretion system (fT3SS) transports flagellar building blocks from the cytoplasm to the distal end of the growing flagellar structure 2 . The fT3SS is divided into three structural parts: a transmembrane export gate complex made of FlhA, FlhB, FliP, FliQ, and FliR, a substrate-chaperone-docking platform composed of the cytoplasmic domains of FlhA and FlhB (FlhA C and FlhB C ), and a cytoplasmic ATPase ring complex consisting of FliH, FliI, and FliJ 3 . The FlhA C –FlhB C -docking platform provides binding sites for the cytoplasmic ATPase complex, flagellar export chaperones (FlgN, FliS, FliT), and export substrates to mediate hierarchical protein targeting and secretion 4 .…”
Section: Introductionmentioning
confidence: 99%