Molecular organization of the lipid matrix in intact Stratum corneum using ATR-FTIR spectroscopy

Boncheva, Mila; Damien, Fabienne; Normand, Valéry

doi:10.1016/j.bbamem.2008.01.022

Cited by 223 publications

(169 citation statements)

References 54 publications

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“…It is not clear how the cholesterol molecules are distributed between the phases. Several studies with isolated SC, model lipid mixtures and human skin equivalents have shown presence of phase-separated, pure cholesterol crystals [49,98]; little is known about them.The solid-solid phase transition (between OR and HEX) occurs at physiologically relevant temperatures, around 35-40°C [66,99]. The solid-liquid transition (between OR or HEX and LIQ) occurs at non-physiological temperatures, around 70°C, but it can be caused by changes in the phase composition, for example by topical application of chemicals [85].…”

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confidence: 99%

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The physical chemistry of the stratum corneum lipids

Boncheva

2014

Intern J of Cosmetic Sci

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SynopsisThe extracellular matrix of stratum corneum (SC) participates actively in the defensive performance of human skin. Understanding its physicochemical properties is essential for understanding the skin homoeostasis, for the development of efficient therapies for skin disorders and diseases and for ensuring the safety of products designed for topical application. This article summarizes the current knowledge of the composition, self-assembly and molecular organization of the SC lipids, reviews the evidence connecting these parameters and the barrier properties of human skin, and outlines the immediate issues in the field of SC lipid research. R ESUM E: La matrice extracellulaire du stratum corneum (SC) participe activement a la performance d efensive de la peau humaine. Comprendre ses propri et es physico-chimiques est essentielle pour comprendre l'hom eostasie de la peau, pour le d eveloppement de th erapies efficaces pour les troubles et les maladies de la peau, et pour assurer la s ecurit e des produits conc ßus pour une application topique. Cet article r esume les connaissances actuelles sur la composition, l'auto-assemblage, et l'organisation mol eculaire des lipides SC, examine les preuves reliant ces param etres et les propri et es de barri ere de la peau humaine, et d ecrit les probl emes imm ediats dans le domaine de la recherche sur les lipides SC. IntroductionThe field of skin research is replete with opportunities for those intent on working on scientifically interesting topics while making a noticeable, positive difference in people's lives [1]. The range of important problems that the field can help solving is broad. It comprises (i) reducing infant mortality, especially in the developing countries where defective skin barrier is the second major cause of preterm mortality [2][3][4][5][6]; (ii) improving the skin health of some 20-30% of the population in the developed countries which suffer from some sort of skin barrier dysfunction [7,8]; (iii) developing efficient strategies for the dermal and transdermal delivery of drugs and vaccines [9]; (iv) increasing the national and personal security by developing methods to retard or prevent the skin penetration of chemical warfare agents, toxic spills and pesticides [10, 11]; (v) enhancing the safety of topical products (e.g. fragrances, cosmetics, cleansing agents, sunscreens and insect repellents) [12]. Thus, the targets in skin research cover the full spectrum from counter-acting leaky skin and preventing its penetration by chemicals to pushing chemicals through it. One common major problem underlies these diverse topics: our insufficient understanding of the factors that determine skin permeability.Understanding the permeability of human skin to a large extent means understanding the extracellular lipid matrix of the stratum corneum (SC), the topmost skin layer which constitutes the main barrier to transdermal fluxes [13][14][15][16][17][18][19]. As the lipid matrix forms an uninterrupted pathway from the skin surface to the viable skin tissu...

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confidence: 99%

“…The solid-solid phase transition (between OR and HEX) occurs at physiologically relevant temperatures, around 35-40°C [66,99]. The solid-liquid transition (between OR or HEX and LIQ) occurs at non-physiological temperatures, around 70°C, but it can be caused by changes in the phase composition, for example by topical application of chemicals [85].…”

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confidence: 99%

The physical chemistry of the stratum corneum lipids

Boncheva

2014

Intern J of Cosmetic Sci

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“…The information tells us about several micrometres of surface; thus, it is also a useful method for analysing skin [45,46]. ATR-FTIR spectra can give us information about hydration of skin [47], structure of proteins [48] and lipids [49] and about their changes during skin treatment by chemical or other drug enhancers [50,51]. There are several vibrational bands associated with chemical functional groups.…”

Section: Diagnostics Of Barrier Properties Of the Skin-tewl (Transepimentioning

confidence: 99%

“…Vibrational bands at 2850 and 2920 cm −1 belong to CH 2 symmetric and asymmetric stretching modes, respectively [52]. The absorbance of the spectrum decreases as the thickness of the skin decreases and the wavenumber indicates a change in chain conformation, especially a change in peak shape [49].…”

Section: Diagnostics Of Barrier Properties Of the Skin-tewl (Transepimentioning

confidence: 99%

Enhancement of Percutaneous Absorption on Skin by Plasma Drug Delivery Method

Shimizu¹,

Krištof²

2017

Advanced Technology for Delivering Therapeutics

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Transdermal drug delivery (TDD) is a painless method of low-dose drug delivery. The advantages and disadvantages of transdermal drug delivery methods are named and basic methods such as using chemical enhancers, iontophoresis and electrophoresis are introduced. One of the promising methods make use of plasma which is generated in atmospheric pressure mostly in volume or on surface dielectric barrier discharge (DBD) or in plasma jet. As the plasma produces various particles according to the used gas, UV radiation and heat, their effects on skin and barrier function are described. Improvement of transdermal drug delivery of hydrophilic drug galantamine hydrobromide (GaHBr) using microplasma electrode is introduced.

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“…It is poorly absorbed from the gastrointestinal tract; Gastrointestinal absorption of vitamin B12 depends on the presence of sufficient intrinsic factor . Percutaneous absorption of B 12 in guinea pig and rat has been investigated and it was demonstrated that absorption was more efficient from an ethanol solution than from water or dimethyl sulfoxide, and also it was independent of the quantity of vitamin applied to a given area [9].…”

Section: Introductionmentioning

confidence: 99%