Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations

Husseiny, Ebtehal M.; Abulkhair, Hamada S.; Saleh, Asmaa; Altwaijry, Najla; Zidan, Riham A.; Abdulrahman, Fatma G.

doi:10.1016/j.bioorg.2023.106789

Bioorganic Chemistry

2023

DOI: 10.1016/j.bioorg.2023.106789

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Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations

Ebtehal M. Husseiny,

Hamada S. Abulkhair,

Asmaa Saleh

et al.

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Cited by 4 publications

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Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations

Cited by 4 publications

References 54 publications

Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers

Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers

Novel imidazolone derivatives as potential dual inhibitors of checkpoint kinases 1 and 2: Design, synthesis, cytotoxicity evaluation, and mechanistic insights

In vivo evaluation of novel synthetic pyrazolones as CDK9 inhibitors with enhanced pharmacokinetic properties

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