Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options

Cai, Xiaopeng; Cai, Huiqiang; Wang, Jing; Yang, Qin; Guan, Jun; Deng, Jingwen; Chen, Zhi

doi:10.1631/jzus.b2100977

Cited by 27 publications

(26 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Then research progress in the pathological mechanisms of AILI is discussed. It is now recognized that the pathological process of AILI includes multiple intra-and extracellular activities, such as mitochondrial oxidative stress, endoplasmic reticulum stress, aseptic inflammation, bile acid cycle, and microcirculatory dysfunction (Cai et al, 2022b). Therefore, many processes other than mitochondrial oxidative stress and dysfunction can be potential targets for AILI treatment.…”

Section: Discussionmentioning

confidence: 99%

Advances in the study of acetaminophen-induced liver injury

Chen

2023

Front. Pharmacol.

View full text Add to dashboard Cite

Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury (AILI) is challenging because of the complex mechanisms involved. Starting from the current studies on the mechanisms of AILI, this review focuses on novel findings in the field of diagnosis, screening, and management of AILI. It highlights the current issues that need to be addressed. This review is supposed to summarize the recent research progress and make recommendations for future research.

show abstract

Section: Discussionmentioning

confidence: 99%

Advances in the study of acetaminophen-induced liver injury

Chen

2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…APAP-induced ROS can lead to the release of various DAMPs by inducing hepatocyte death during the development of DILI, thereby recruiting monocytes/ macrophages and neutrophils. A large number of inflammatory factors and ROS are generated and a vicious cycle of inflammation and ROS is formed, which exacerbates APAP-induced liver injury (Yan et al, 2018;Cai et al, 2022). Therefore, the effect of EGM NPs on inflammatory response is also worthy of further study.…”

Section: Egm Nps Inhibit Inflammation During Apap-induced Liver Injurymentioning

confidence: 99%

“…The role of reactive oxygen species (ROS) and inflammation is indeed essential for the pathogenesis of DILI, including liver injury induced by APAP (Ye et al, 2018;Cai et al, 2022). Specifically, APAP is converted into N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive metabolite, by cytochrome P450 enzyme (CYPs).…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress

et al. 2022

View full text Add to dashboard Cite

Drug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses. However, traditional treatments were limited by low efficacy and serious side effects due to the special liver structure. Here, we developed a molybdenum (Mo)-based nanoparticles, EGM NPs, after overall consideration of the pathophysiology of DILI and the advantages of nanodrugs. It demonstrated that EGM NPs treated acetaminophen (APAP)-induced DILI by scavenging ROS and inhibiting inflammation. EGM NPs effectively scavenged various ROS and reduced cell apoptosis at the cellular level. More importantly, EGM NPs can treat APAP-induced DILI in vivo, reducing the levels of liver function indicators in mice with liver injury, scaling down the area of hepatocyte necrosis and successfully inhibiting endoplasmic reticulum (ER) stress in the liver. EGM NPs also showed a certain anti-inflammatory effect by reducing infiltration of macrophages, decreasing pro-inflammatory factors and inhibiting the expression levels of inducible nitric oxide synthase (NOS2) and myeloperoxidase (MPO). Collectively, our findings suggest that EGM NPs-based nanotherapeutic is a novel strategy for the treatment of DILI.

show abstract

“…The waterweed is a good way to avoid the eutrophication of water. It can absorb excess nitrogen and phosphorus [24]. Furthermore, in the high-temperature season, waterweed can play a cooling role to prevent the damage caused by high temperature to the growth of adult crabs [25].…”

Section: The Effect Of Waterweed Coverage On the Growth Of Crabsmentioning

confidence: 99%

Effect of Water Area and Waterweed Coverage on the Growth of Pond-Reared Eriocheir sinensis

Tang

Peng

Zhao

et al. 2022

Fishes

View full text Add to dashboard Cite

Water area and waterweed coverage are the key environmental factors for ecological breeding of Eriocheir sinensis in ponds. In order to explore the effects of above two factors on the growth of E. sinensis, three groups of experiments were set up: low coverage small area (C1S1), high coverage small area (C2S1), and high coverage large area (C2S2), and water environmental factors and the growth of E. sinensis were monitored. The results showed that the dissolved oxygen of ponds with different waterweed coverage was significantly different (p < 0.05), and the phosphate in ponds changed significantly from July to October (p < 0.05). The correlation analysis showed that NH3-N and pH were significantly positively correlated (p < 0.05). At the same time, there was a significant negative correlation between NH3-N and DO, H3PO4 and pH (p < 0.05). Further analysis of the relationship between surface area, waterweed coverage and environmental factors revealed that the surface area and waterweed coverage were closely related to NH3-N, H3PO4 and DO. From July to October, the differences in morphology and weight of E. sinensis in different ponds became more and more significant. In terms of growth rate, C1S1 with a small area and low coverage had a downward trend, while C2S1 and C2S2 were the opposite. In the final stage of the experiment, C2S2 had the highest yield (0.1311 kg/m2), and C1S1 had the lowest yield (0.0600 kg/m2). Then, the ponds with high waterweed coverage and large area can bring better benefits.

show abstract

Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options

Cited by 27 publications

References 135 publications

Advances in the study of acetaminophen-induced liver injury

Advances in the study of acetaminophen-induced liver injury

Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress

Effect of Water Area and Waterweed Coverage on the Growth of Pond-Reared Eriocheir sinensis

Contact Info

Product

Resources

About