Molecular Pathology

Oyejide, Lekan; Mendes, Odete; Mikaelian, Igor

doi:10.1016/b978-0-12-803620-4.00016-5

Cited by 8 publications

(1 citation statement)

References 255 publications

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“…A biomarker is a substance that can be measured in a biological system as an indicator of exposure and susceptibility of the disease and can indicate physiological stage and pathological processes 96 . Also, a biomarker can be used to monitor patients' conditions after medical interventions or administration of therapeutics 97,98 . However, the use of a single biomarker for the CVDs diagnosis has some drawbacks such as limited accuracy because a single biomarker can be associated with multiple diseases.…”

Section: Electrochemical Paper-based Analytical Device For Multiplexe...mentioning

confidence: 99%

Electrochemical paper-based immunosensor for biomarkers detection

Boonkaew¹

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This dissertation focused on the development of electrochemical paper-based immunosensor for determining essential biomarkers by using a label-free immunoassay. This dissertation can be divided into four main parts. In the first part, an origami paper-based analytical device (oPAD) was developed for c-reactive protein (CRP) detection. oPAD was designed to combine the preparation of immunosensor and detection step into a single device. A gold nanoparticle modified graphene screen-printed carbon electrode (AuNPs/G/SPCE) was utilized to enhance the sensitivity of the electrode. The developed sensor was successfully applied to determine CRP in a certified serum sample. For the second part, an electrochemical paper-based analytical device (ePAD) was created for simultaneous determination of three crucial cardiovascular disease (CVD) biomarkers including CRP, troponin I (cTnI), and procalcitonin (PCT). The proposed ePAD has multiple detection zones and multiple working electrodes, which could enable simultaneous three biomarkers in a single sample with high sensitivity and selectivity. For the third part, a simple and low-cost ePAD immunosensor for ferritin determination was reported. The ePAD was custom designed on the filter paper to successfully fabricate an immunosensor. The working electrode was first modified with graphene oxide (GO) using an inkjet-printing technique to enhance the reproducibility of the electrode. The ePAD was finally applied in a practical sample, giving results that are in agreement with the standard method. Lastly, an ePAD was architecturally designed for simultaneous detection of hepatitis B (HBV) and hepatitis C core antigen (HCV). The fast-flow and delayed channels were created to control the flow velocity on an ePAD device. To validate the sensor performance, the developed immunosensor was applied to measure the known amount of HBV and HCV in the serum samples. All developed immunosensors provided good performances for biological and clinical diagnosis and allowed for further development of an advanced platform.

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Section: Electrochemical Paper-based Analytical Device For Multiplexe...mentioning

confidence: 99%

Electrochemical paper-based immunosensor for biomarkers detection

Boonkaew¹

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Cardiac Tissue Engineering: A Journey from Scaffold Fabrication to In Vitro Characterization

Ketabat,

Alcorn,

Kelly

et al. 2024

Small Science

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Cardiac tissue engineering has been rapidly evolving with diverse applications, ranging from the repair of fibrotic tissue caused by “adverse remodeling,” to the replacement of specific segments of heart tissue, and ultimately to the creation of a whole heart. The repair or replacement of cardiac tissue often involves the development of tissue scaffolds or constructs and the subsequent assessment of their performance and functionality. For this, the design and/or selection of biomaterials, and cell types, scaffold fabrication, and in vitro characterizations are the first starting points, yet critical, to ensure success in subsequent implantation in vivo. This highlights the importance of scaffold fabrication and in vitro experiments/characterization with protocols for cardiac tissue engineering. Yet, a comprehensive and critical review of these has not been established and documented. As inspired, herein, the latest development and advances in scaffold fabrication and in vitro characterization for cardiac tissue engineering are critically reviewed, with focus on biomaterials, cell types, additive manufacturing techniques for scaffold fabrication, and common in vitro characterization techniques or methods. This article would be of benefit to the ones who are working on cardiac tissue engineering by providing insights into the scaffold fabrication and in vitro investigations.

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Advancements in Cytological Techniques in Cancer

Díaz del Arco,

Saiz Robles

2023

Handbook of Cancer and Immunology

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Molecular Pathology

Cited by 8 publications

References 255 publications

Electrochemical paper-based immunosensor for biomarkers detection

Electrochemical paper-based immunosensor for biomarkers detection

Cardiac Tissue Engineering: A Journey from Scaffold Fabrication to In Vitro Characterization

Advancements in Cytological Techniques in Cancer

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