Molecular pathways of apoptotic cell death

Walia, Ramanpreet; Madaan, Reecha; Chaudhary, Komal; Mehta, B. V.; Bala, Rajni

doi:10.1016/b978-0-12-815762-6.00003-2

Cited by 2 publications

(1 citation statement)

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“…Apoptosis is a process that is important for a variety of biological processes, including immunological function, normal cell turnover, embryonic development, metamorphosis and hormone-dependent atrophy. (4) . Among the cysteine proteases that are involved in the processing of cytokines and apoptosis is Caspase-8, which like all other caspases is created as a single polypeptide chain zymogen procaspase that is inactive.…”

Section: Introductionmentioning

confidence: 99%

The effect of caspase-8 as an apoptotic marker in relation to COVID-19 patients severity

Eyada

Al-Timimi

alkubaisi³

et al. 2022

Preprint

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Objective: In Iraq, the COVID-19 pandemic was catastrophic, leading to mortality and morbidity. One of the leading causes of mortality was cell apoptosis that leads to organ failure. Aim: To diagnose the cell apoptosis of COVID-19 patients at an early stage so we can predict earlier organ failure. Methods: The research was conducted in the medicinal chemistry department of Al-Nahrain University/College of Medicine in Baghdad, Iraq. One hundred patients of different stages proved COVID-19 and compared with 100 persons in the control group, measure caspase-8 enzyme and acute inflammatory markers, procalcitonin (PCT), and IL-6 with COVID-19 immunoglobulins IgG, IgM in the blood of two groups. We're done—statical studies with clinical analysis results. Results: The marker of cell apoptosis was caspase-8 enzymes, which showed vertical elevation with the increase in severity of COVID-19 patients. There was a strong relationship between the caspase-8 enzyme and acute inflammatory markers. Moreover, there is a relationship between the caspase-8 enzyme and COVID-19 immunoglobulins. Conclusion: The caspase-8 enzyme is a strong marker of severity in COVID-19 patients and indicates a life-threatening condition.

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Section: Introductionmentioning

confidence: 99%