“…Dying tumor cells release intracellular components such as high-mobility-group box 1, ATP, and DNA, which are recognized, in turn, by receptors such as Toll-like receptor (TLR) 4 (Apetoh et al, 2007), P2X7 receptor (P2X7R) (Ghiringhelli et al, 2009), and stimulator of interferon genes (STING) (Deng et al, 2014) to regulate immune responses against tumors. Accordingly, a number of innate sensor agonists are being brought forward for investigation in cancer patients (Corrales and Gajewski, 2015; Kaczanowska et al, 2013; Rook et al, 2015). …”