Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids

Levêque, Dominique; Jehl, F.

doi:10.1177/0091270007299430

Cited by 58 publications

(41 citation statements)

References 83 publications

(103 reference statements)

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“…CYP3A5 is expressed in a minority of Caucasians (10% in France), meaning that vincristine is probably excreted as unchanged drug in the majority of a Caucasian population [7]. It has to be stressed that, to date, no metabolite of vincristine has been isolated in human biological fluids [1]. Vincristine biliary elimination is probably mediated by the drug transporter P-glycoprotein (P-gp) [1].…”

Section: Discussionmentioning

confidence: 99%

“…It has to be stressed that, to date, no metabolite of vincristine has been isolated in human biological fluids [1]. Vincristine biliary elimination is probably mediated by the drug transporter P-glycoprotein (P-gp) [1]. Ritonavir is a potent CYP3A5 and P-gp inhibitor that is used, beyond its antiretroviral properties, to enhance lopinavir exposure [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…In adults, the drug is given intravenously at the usual dose of 1.4 mg/m 2 , rarely exceeding 2 mg (total dose) weekly. Vincristine pharmacokinetics are characterized by a long terminal halflife (22 h), an extensive volume of distribution (750 l) and a primary hepatic elimination [1]. Paralytic ileus is an infrequent severe gastrointestinal toxicity of vincristine.…”

Section: Introductionmentioning

confidence: 99%

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Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine

et al. 2009

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We speculate that an interaction between ritonavir/lopinavir and vincristine was responsible for this severe toxicity. Vincristine is transported by P-gp and is metabolized via CYP3A5. Ritonavir is a potent CYP3A5 isoenzyme and P-gp inhibitor. Lopinavir is also a P-gp inhibitor. Ritonavir and lopinavir might have delayed vincristine elimination. Clinicians should be aware of this possible interaction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine

et al. 2009

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“…Furthermore, several undesirable effects have been proclaimed for these drugs such as myelotoxicity, alopecia, abdominal cramps, constipation, nausea/vomiting, paralytic ileus, ulcerations of the mouth, kidney impairment, urinary retention, hepatocellular damage, pulmonary fibrosis, amenorrhea, azoospermia, orthostatic hypotension, and hypertension (Nejat et al 2015). The drug dosage and route of administration should be carefully managed to lessen undesirable toxic effects (Sherines and Howard 1978;Leveque and Jehl 2007;James et al 2007;Nobili et al 2009). …”

Section: Toxicity and Side Effectsmentioning

confidence: 99%

“…It is consider as one of the most expensive plant-derived compounds in the international market with significant undesirable effects. Vinblastine correspondingly reduces the number of white blood cells in the blood (Leveque and Jehl 2007). In the world trade, vinblastine sulfate has now been sold for over 40 years as an antineoplastic agent.…”

Section: Pharmaceutical Production and International Tradementioning

confidence: 99%

Agricultural, Pharmaceutical, and Therapeutic Interior of Catharanthus roseus (L.) G. Don

Barkat

Abul²,

Rahman

2017

Catharanthus Roseus

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Catharanthus roseus (C. roseus) (L.) G. Don known as Madagascar periwinkle (MP) is a popular ornamental plant found in gardens and homes across the world. C. roseus (L.) G. Don has been widely distributed for long enough and gained popularity as diverse application in medicinal uses for a variety of purposes such as antimicrobial, antioxidant, anthelmintic, antifeedant, antisterility, antidiarrheal, and antidiabetic effect and have been used in the treatment of leukemia, Hodgkin's disease, malignant lymphomas, neuroblastoma, Wilms tumor, Kaposi's sarcoma, and mycosis fungoides to improve cerebral blood flow and treat high blood pressure. The pharmacology of the plant was found to be associated mostly especially with the alkaloids that occupies almost all parts of the plant. C. roseus (L.) G. Don is a legendary medicinal plant mostly because of possessing two invaluable antitumor terpenoid indole alkaloids (TIAs), vincristine and vinblastine. The ethnobotanical significance of C. roseus (L.) G. Don is exemplified by its international usage as a traditional remedy for abundant ailments and not only for cancer. TIAs are present only in micro quantities in the plant and are highly poisonous per se rendering a challenge for researchers to increase yield and reduce toxicity. Good agronomic practices ensure generous propagation of healthy plants that serve as a source of bioactive compounds and multitudinous horticultural applications. In this chapter, an attempt has been made to summarize the agricultural, pharmaceutical,

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Agents Targeting Microtubules and Mitotic Processes

Rowinsky

2017

Holland‐Frei Cancer Medicine

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Overview The treatment of many diseases owes much to the importance of medicines derived from natural sources, and the treatment of malignant disease is no exception. Billions of years of evolutionary pressure have resulted in the natural selection of plants, fungi, and microorganisms capable of producing potent and specific toxins. After several plant‐derived compounds and other natural products, many of which targeted the mitotic processes, demonstrated prominent anticancer activity in the 1950s and 1960s, the microtubule was recognized as a subcellular target of major strategic importance. The first widely used class of antimicrotubule agents, the plant‐derived vinca alkaloids, had been the mainstay of both palliative and curative regimens for treating malignancies for several decades. The addition of the plant‐derived taxanes, which possess a unique mechanism of action and anticancer spectra, to our therapeutic arsenal several decades later resulted in renewed interest in the microtubule and mitotic processes as targets for which to develop cancer therapeutics, as well as in the identification of other natural products to treat cancers. More recently, several plant‐ and marine‐derived compounds as well as synthetic agents with yet even more distinctive disruptive actions on microtubules and other mitotic constituents have been identified. These include the analogs of the epothilones and halichondrin B, which were isolated from soil‐dwelling myxobacterium and marine sponges, respectively. They also include potent antimicrotubule agents, such as analogs of maytansine and dolastatin, which are components of antibody‐drug conjugates. This chapter focuses on the microtubule as a target for therapeutic development and antimicrotubule agents that comprise our therapeutic armamentarium.

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Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids

Cited by 58 publications

References 83 publications

Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine

Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine

Agricultural, Pharmaceutical, and Therapeutic Interior of Catharanthus roseus (L.) G. Don

Agents Targeting Microtubules and Mitotic Processes

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