IntroductionOral cancer is the malignant tumors that occur in the oral cavity, including tongue cancer, gum cancer, buccal mucosal cancer, lip cancer, and jaw cancer 1, 2 . Oral cancer is the fourth cause of death and the number of cancer deaths among male Chinese. Smoking will greatly increase the incidence of oral cancer. The treatment of oral cancer has achieved great advances. However, up to now, only a small number of patients could be totally cured, and the final outcome of most patients is still not optimistic. The recurrence and metastasis of malignant tumors is still the biggest risk 3 . In 1999, Tubiana reported that 45 of cancer patients could be thoroughly cured. Over the past ten years, a lot of progress has been made, and at present, nearly 50 of malignant tumor patients can survive for more than 5 years, indicating more than half are still of malignant tumor patients cannot be cured. The surgery, radiation, chemotherapy, and immunotherapy were the common therapy method for the cancer treatment, which could sig- § Authors are contributed equally to this work.