Molecular polymorphism of the ABO blood group: A study in Poland, Spain, and Andorra

Umbria, Miriam; Cantons, Jordi; Bruguera, Carmina; Minias, Alina; Duró, Chantal Backes de; Catalano, Giulio; Santos, Cristina; Nogués, Ramón M.; Aluja, María Pilar

doi:10.1002/ajhb.22544

Cited by 1 publication

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“…This frequency is comparable to the other Middle East and Asian populations as well as in some populations from South America and Europe. [ 7 13 14 17 18 ] The O02 allele was more frequent among the Dhodias (0.4265) as compared to the Parsis (0.3971) and the mixed group (0.3521).…”

Section: Resultsmentioning

confidence: 99%

“…detected all the three above mentioned less common alleles among Spanish and Polish groups from Spain and Poland, respectively. [ 13 ]…”

Section: Discussionmentioning

confidence: 99%

“…A handful of reports on the distribution of O alleles are available from South America, Africa, Europe, Middle East, and Asia. [ 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 ] These studies illustrate lot of heterogeneity among the O alleles. The O01 and O02 are the most common alleles seen in these studies.…”

Section: Introductionmentioning

confidence: 92%

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Heterogeneity of O blood group in India: Peeping through the window of molecular biology

Gogri

Ray

Agrawal

et al. 2018

Asian J Transfus Sci

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BACKGROUND:Molecular genotyping of ABO blood group system has identified more than 60 “O” group alleles based on the single-nucleotide polymorphisms present in the ABO gene. Heterogeneity of O group alleles has been observed in various countries from South America, Europe, Middle East, and Asia. India is a vast country with more than 1300 million population which is divided into various ethnic and tribal groups. However, very little is known about the heterogeneity of O alleles in Indians.MATERIALS AND METHODS:A total of 116 O group individuals from the mixed population of Mumbai, India, were enrolled in the present study. DNA was extracted using the standard phenol–chloroform method. The exons 6 and 7 of the ABO gene were genotyped by polymerase chain reaction-single-strand conformation polymorphism and/or DNA sequencing. The genotyping results were compared with our earlier findings.RESULTS AND DISCUSSION:Overall, ten different genotypes were identified. Three rare alleles, namely, O05, O11, and O26 were seen in the mixed group category. These results suggest that there is an internal heterogeneity in the mixed group while Dhodias and Parsis, the groups which were screened earlier, seem to be more homogenous groups. An important piece of information emerges out from this study, that is, O01O02 genotype is expressing some selective force in population groups screened in India as well as many other groups worldwide.CONCLUSION:In the future, molecular genotyping of the ABO blood group system among different ethnic and tribal Indian groups would help in generating data to fill up the gaps in the molecular ABO map of the world.

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Section: Resultsmentioning

confidence: 99%

“…detected all the three above mentioned less common alleles among Spanish and Polish groups from Spain and Poland, respectively. [ 13 ]…”

Section: Discussionmentioning

confidence: 99%

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Heterogeneity of O blood group in India: Peeping through the window of molecular biology

Gogri

Ray

Agrawal

et al. 2018

Asian J Transfus Sci

View full text Add to dashboard Cite

show abstract

Molecular polymorphism of the ABO blood group: A study in Poland, Spain, and Andorra

Abstract: The results obtained contribute to the knowledge of the molecular European ABO map, and are discussed in regard to the allelic frequency reported by other Caucasian and Asian populations.

Cited by 1 publication

References 16 publications

Heterogeneity of O blood group in India: Peeping through the window of molecular biology

Heterogeneity of O blood group in India: Peeping through the window of molecular biology

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