Molecular prevalence of hepatitis C virus genotypes in district Kohat, Khyber Pakhtunkhwa, Pakistan

Ullah, Farman; Ali, Nawab; Ali, Irum Sabir; Saleha, Shamim; Shah, Syed Tahir Ali; Rahman, Hazir; Ahmad, Muhammad Jamil Shahbaz; Saeed, Muhammad

doi:10.19045/bspab.2017.60019

Cited by 13 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highest percentage of HCV 27.3% was observed in the age group 31–40 years whereas the median age of study participants was 31–50.8 years. The results when compared with a similar study[ 13 ] conducted in the general population of Pakistan almost correlated with young patients of up to 40 years. However, when comparing with a second study published in 2019 at an outreach center for screening and treatment in Pakistan,[ 14 ] it was found that most older age people (>61 years) were positive.…”

Section: Discussionmentioning

confidence: 63%

Predictive factors for acquiring HCV infection in the population residing in high endemic, resource-limited settings

Khan

Shah

Ashraf

2021

Journal of Family Medicine and Primary Care

View full text Add to dashboard Cite

Background: In a country like Pakistan, a high prevalence of HCV persists due to a lack of awareness among the masses and the absence of adequate medical facilities in less privileged areas. Therefore, this study aimed to develop a risk-based screening tool based on the identification of predictive factors for HCV in the adult population in Karachi, Pakistan, which can later be validated for implementation. Methodology: A case-control study design was adopted and data was collected through an interview-based questionnaire from among 284 patients visiting the Family Medicine Department at The Indus Hospital, Karachi on whom the anti-HCV antibody test was conducted. Received data was then entered and analyzed using Statistical Package for the Social Sciences (SPSS) version 21.0. Result: Analysis indicated that in the entire cohort, marital status, employment status, history of being operated on in the past, family history of HCV infection, and body piercing were the factors significantly associated with positive HCV antibody. Results thus achieved show that the anti-HCV-positive rate was higher in ever married, employed, having had surgery, and family history of HCV infection (aOR: 2.42, 3.5, 2.04 and 2.5, P = 0.043, 0.002, 0.011 and 0.005, respectively). Conclusions: It is concluded that future research may be conducted enrolling the heterogeneous population to further probe the HCV burden and incidence in our society to initiate educational purposes. This goal can be achieved through commercial advertisements and free public lectures for disease prevention and better health awareness among the masses and the curers.

show abstract

Section: Discussionmentioning

confidence: 63%

Predictive factors for acquiring HCV infection in the population residing in high endemic, resource-limited settings

Khan

Shah

Ashraf

2021

Journal of Family Medicine and Primary Care

View full text Add to dashboard Cite

show abstract

“…Among the 1961 initially identified studies, 71 were included in the review and meta‐analysis, 21–91 as described in the flow diagram (Figure 1). The total number of participants across all selected studies was 120,568.…”

Section: Resultsmentioning

confidence: 99%

Meta‐analysis: risk of hepatitis C virus infection associated with hospital‐based invasive procedures

Henriot

Castry

Ngũyen

et al. 2022

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary Background Healthcare settings, where invasive procedures are frequently performed, may play an important role in the transmission dynamics of blood‐borne pathogens when compliance with infection control precautions is suboptimal. Aims To understand and quantify the role of hospital‐based invasive procedures on hepatitis C virus (HCV) transmission. Methods We conducted a systematic review and meta‐analysis to identify recent studies reporting association measures of HCV infection risk that are linked to iatrogenic procedures. Based on expert opinion, invasive procedures were categorised into 10 groups for which pooled measures were calculated. Finally, the relationship between pooled measures and the country‐level HCV prevalence or the Healthcare Access and Quality (HAQ) index was assessed by meta‐regression. Results We included 71 studies in the analysis. The most frequently evaluated procedures were blood transfusion (66 measures) and surgery (43 measures). The pooled odds ratio (OR) of HCV infection varied widely, ranging from 1.46 (95% confidence interval: 1.14–1.88) for dental procedures to 3.22 (1.7–6.11) for transplantation. The OR for blood transfusion was higher for transfusions performed before 1998 (3.77, 2.42–5.88) than for those without a specified/recent date (2.20, 1.77–2.75). In procedure‐specific analyses, the HCV infection risk was significantly negatively associated with the HAQ for endoscopy and positively associated with HCV prevalence for endoscopy and surgery. Conclusions Various invasive procedures were significantly associated with HCV infection. Our results provide a ranking of procedures in terms of HCV risk that may be used for prioritisation of infection control interventions, especially in high HCV prevalence settings.

show abstract

Epidemiology and Genotypes of Hepatitis C Virus: A First Study from Jammu (J & K), India

Sharma¹,

Sharma²,

Sehgal³

et al. 2017

Journal of Gastrointestinal Infections

View full text Add to dashboard Cite

Background and objectives: Globally, around 200 million people are infected with hepatitis C virus (HCV). India contributes a big proportion of HCV burden with the prevalence estimated between 0.5 and 1.5%. Northeastern tribal populations and areas of Punjab represent the HCV infection hotspots, while in Western and Southern parts of the country, the prevalence is lower. The distribution of HCV genotypes is highly variable. This study was particularly planned to attain knowledge of the prevalent HCV genotypes in Jammu province of Jammu and Kashmir (J&K) state. Materials and methods:Blood samples of patients attending the Department of Medicine, Government Medical College (GMC), Jammu and Kashmir, India, for HCV testing were subjected to serological test at Department of Microbiology, GMC, Jammu. The serum samples were tested for anti-HCV antibodies by enzyme-linked immunosorbent assay (ELISA) and positive samples were subjected to genotyping. Conclusion:Of the 396 samples tested, 33 (8.33%) were found to be HCV positive and 23 of these were included for genotyping. Genotypes 3 and 1 were detected in this region and this was in accordance with other national studies. There is a need for larger field studies to better understand the HCV epidemiology and identify higher prevalence areas and also the distribution of genotypes of HCV. This, being a maiden study from this region, will shed light to allow apposite choice and target efforts for better management of the disease and reduce the burden of chronic liver disease due to HCV.

show abstract

Molecular prevalence of hepatitis C virus genotypes in district Kohat, Khyber Pakhtunkhwa, Pakistan

Cited by 13 publications

References 19 publications

Predictive factors for acquiring HCV infection in the population residing in high endemic, resource-limited settings

Predictive factors for acquiring HCV infection in the population residing in high endemic, resource-limited settings

Meta‐analysis: risk of hepatitis C virus infection associated with hospital‐based invasive procedures

Epidemiology and Genotypes of Hepatitis C Virus: A First Study from Jammu (J & K), India

Contact Info

Product

Resources

About