Molecular prevalence of Merkel cell polyomavirus in nonmelanoma skin cancer in a Brazilian population

Bellott, Thiago Rubin; Baez, Camila Freze; Almeida, Sandra Maria Garcia de; Venceslau, Marianna Tavares; Zalis, Mariano Gustavo; Guimarães, Maria Angélica Arpon Marandino; Rochael, Mayra C; Luz, Flávio Barbosa; Varella, Rafael Brandão; Almeida, Jorge Reis

doi:10.1111/ced.13069

Cited by 11 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our series, we demonstrated the high prevalence of MCPyV in Brazilian patients with MCC (100% of 13 samples tested), a prevalence rate higher than reported in Japan, Germany, and France, which ranged from 78% to 88.5% . Furthermore, we identified the presence of MCPyV DNA in 20% of patients with non‐MCC tumors, which agrees with the literature data that show a prevalence range from 12% to 37.5% in non‐MCC skin cancers . We could also observe that the majority of tumors developed on sun‐exposed areas, mainly on the head and upper limbs.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

The first observation of the association of Merkel cell polyomavirus and Merkel cell carcinoma in Brazil

et al. 2019

View full text Add to dashboard Cite

Background Merkel cell carcinoma (MCC) is a rare but aggressive primary cutaneous carcinoma with high mortality rates. The present study intends to delineate the epidemiological profile of patients with MCC seen at the Clinics Hospital of the Medical School at the University of São Paulo, Brazil, and its association with Merkel cell polyomavirus (MCPyV). Methods This is a retrospective study. A search was performed in the hospital's medical index for all cases of MCC from January 1994 to December 2012. Among patients with MCC, the available tumoral skin specimens were analyzed with two different techniques of polymerase chain reaction (PCR) (conventional and real‐time) for detection of MCPyV DNA. Additionally, paraffin‐embedded samples of patients with non‐MCC skin cancers were also analyzed. Analyses suitable for categorical data (i.e., x² of Fisher) were used to compare the proportion of patients in each group. Results Nineteen patients with MCC and 20 patients with non‐MCC skin cancers entered the study. All MCC samples available (13) tested positive for the presence of MCPyV DNA; however, in the non‐MCC skin cancer samples, the MCPyV DNA was detected in 4 of 20 samples (20%). MCPyV DNA detection rate was higher in patients with MCC than in the other group, and its analysis was statistically significant (P < 0.01). Conclusions This study demonstrates the association of MCPyV in Brazilian patients with MCC. However, further studies are necessary to determine the exact involvement of MCPyV in MCC pathogenesis and to define the significance of viral DNA detection in non‐MCC skin cancers.

show abstract

Section: Discussionsupporting

confidence: 90%

“…2,8 Furthermore, we identified the presence of MCPyV DNA in 20% of patients with non-MCC tumors, which agrees with the literature data that show a prevalence range from 12% to 37.5% in non-MCC skin cancers. 9,18 We could also observe that the majority of tumors developed on sun-exposed areas, mainly on the head and upper limbs.…”

Section: Discussionmentioning

confidence: 87%

The first observation of the association of Merkel cell polyomavirus and Merkel cell carcinoma in Brazil

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Twenty three studies ( 10 , 13 , 19 , 21 , 25 , 29 , 30 , 35 , 40 – 45 , 47 – 49 , 51 – 54 , 56 , 60 ) reported the prevalence rate of MCPyV+ in squamous cell carcinoma samples, with the overall prevalence rate was 15%(95% CI = 9% - 22%, I 2 = 77.3%, P <0.05)( Figure 4B ). The pooled prevalence rate remained similar in the stratified analysis, with statistically significant heterogeneity across all subgroups( Table 2 and Figures S13-15 ).…”

Section: Resultsmentioning

confidence: 99%

“…The 18 included studies ( 11 , 16 , 19 , 21 , 22 , 29 , 30 , 40 , 42 , 44 – 46 , 48 , 51 , 52 , 54 , 59 , 60 ) reported the prevalence rate of the MCPyV+ in basal cell carcinoma, with the overall prevalence rate was 14%(95% CI = 7% - 22%, I 2 = 82.58%, P <0.05)( Figure 4C ). Stratification analysis showed increasing trends for American studies 24%(95% CI = 13% - 38%) and stable trends for European 19%(95% CI = 8% - 32%) and Asian studies 5%(95% CI = 1% - 12%).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

The prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial. To systematically assess the association between MCPyV infection and MCC, non-MCC skin lesions, and normal skin. For this systematic review and meta-analysis, a comprehensive search for eligible studies was conducted using Medline Ovid, Pubmed, Web of Science, and the Cochrane CENTRAL databases until August 2021; references were searched to identify additional studies. Observational studies that investigated the association between MCPyV infection and MCC, non-MCC skin lesions, and normal skin using polymerase chain reaction(PCR) as a detection method and provided sufficient data to calculate the prevalence of MCPyV positivity. A total of 50 articles were included in the study after exclusion criteria were applied. Two reviewers independently reviewed and assessed the eligibility of the studies, and all disagreements were resolved by consensus. To determine the association between MCPyV and MCC, overall odds ratio (OR) were calculated with 95% CI using a random-effects model. Single-arm meta-analyses were performed to examine the prevalence rate of MCPyV+ in MCC, non-MCC skin lesions, and normal skin. The primary analysis was the prevalence rate of MCPyV+ in MCC. Secondary outcomes included the prevalence rate of MCPyV+ in non-MCC skin lesions and normal skin. A total of 50 studies involving 5428 patients were reviewed based on our inclusion and exclusion criteria. Compared with the control group, MCPyV infection was significantly associated with MCC (OR = 3.51, 95% CI = 2.96 - 4.05). The global prevalence of MCPyV+ in MCC, melanoma, squamous cell carcinoma, basal cell carcinoma, Bowen’s disease, actinic keratosis, keratoacanthoma, seborrheic keratosis, and normal skin was 80%, 4%, 15%, 15%, 21%, 6%, 20%, 10%, and 11%, respectively. The current results suggest that MCPyV infection is significantly associated with an increased risk of MCC. However, the low prevalence rate of MCPyV+ in non-MCC skin lesions does not exclude a pathogenic association of this virus with the development of non-MCC skin lesions.

show abstract

“…Conversely, one clinical study involving two cases of BD failed to detect evidence of HPV infection [ 131 ]. BD has also been associated with Merkel cell polyomavirus infection in a Brazilian population study [ 132 ].…”

Section: Influential Role Of Exposome Factorsmentioning

confidence: 99%

Exposome and Skin. Part 2. The Influential Role of the Exposome, Beyond UVR, in Actinic Keratosis, Bowen’s Disease and Squamous Cell Carcinoma: A Proposal

Molina-García

Malvehy

Granger

et al. 2022

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Actinic keratosis (AK) is the main risk factor for the development of cutaneous invasive squamous cell carcinoma (SCC). It represents the first sign of severe chronic ultraviolet radiation exposure, which has a clear significant effect. Nevertheless, the skin is exposed to many other exposome factors which should be thoroughly considered. Our aim was to assess the impact of exposome factors other than ultraviolet radiation (UVR) on the etiopathology of AK and Bowen's disease (BD) and progression of AK to SCC and to design tailored prevention strategies. We performed an exhaustive literature search in September 2021 through PubMed on the impact of exposome factors other than UVR on AK, BD and SCC. We conducted several parallel searches combining terms of the following topics: AK, BD, SCC and microbiome, hormones, nutrition, alcohol, tobacco, viral infections, chemical contaminants and air pollution. Notably, skin microbiome studies have shown how Staphylococcus aureus infections are associated with AK and AK-to-SCC progression by the production of chronic inflammation. Nutritional studies have demonstrated how a caloric restriction in fat intake, oral nicotinamide and moderate consumption of wine significantly reduce the number of premalignant keratoses and SCC. Regarding lifestyle factors, both alcohol and smoking are associated with the development of SCC in a dosedependent manner. Relevant environmental factors are viral infections and chemical contaminants. Human papillomavirus infections induce deregulation of cellular proliferation and are associated with AK, BD and SCC. In addition to outdoor jobs, occupations such as industrial processing and farming also increase the risk of developing keratoses and SCC. The exposome of AK will undoubtedly help the understanding of its etiopathology and possible progression to

show abstract

Molecular prevalence of Merkel cell polyomavirus in nonmelanoma skin cancer in a Brazilian population

Abstract: Despite the frequent detection of MCPyV DNA in NMSC, its possible role in the development of NMSC still needs further investigation.

Cited by 11 publications

References 26 publications

The first observation of the association of Merkel cell polyomavirus and Merkel cell carcinoma in Brazil

The first observation of the association of Merkel cell polyomavirus and Merkel cell carcinoma in Brazil

Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis

Exposome and Skin. Part 2. The Influential Role of the Exposome, Beyond UVR, in Actinic Keratosis, Bowen’s Disease and Squamous Cell Carcinoma: A Proposal

Contact Info

Product

Resources

About