Molecular profile of head and neck rhabdomyosarcomas: A systematic review and meta-analysis

Gallagher, Karen Patricia Domínguez; Heerden, W.F.P. Van; Naief, Nasser Said Al; Carlos, Román; Arboleda, Lady Paola Aristizábal; Rodrigues-Fernandes, Carla Isabelly; Araujo, André; Fonseca, Felipe Paiva; Pontes, Hélder Antônio Rebelo; Innocentini, Lara Maria Alencar Ramos; Romañach, Mário José; Vargas, Pablo Agustín; Lopes, Márcio Ajudarte; Santos‐Silva, Alan Roger; Khurram, Syed Ali

doi:10.1016/j.oooo.2021.12.128

Cited by 1 publication

(2 citation statements)

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“…Furthermore, the follow‐up duration varied among the cases, and the methodological quality analysis evidenced that most of the reports failed to render a clear and complete description of the patient's history in a timeline and the adverse events or harms of the treatment. Moreover, head and neck RMS may have a diverse molecular background, though its association with prognosis has not been established yet 31 . RMS is of the most common cancers in children with the Li‐Fraumeni syndrome and patients harboring germline mutations of TP53 presented RMS at young ages, frequent anaplastic histology, and different locations 32 …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, head and neck RMS may have a diverse molecular background, though its association with prognosis has not been established yet. 31 RMS is of the most common cancers in children with the Li-Fraumeni syndrome and patients harboring germline mutations of TP53 presented RMS at young ages, frequent anaplastic histology, and different locations. 32 The data collection was comprehensive for diverse continents, however, most reports were published recently (2000's) and by authors from North America.…”

Section: Methodological Qualitymentioning

confidence: 99%

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Rhabdomyosarcoma of the oral cavity in children aged 0–2 years: A scoping review

Nunes

Costa

Tavares

et al. 2023

J Oral Pathology Medicine

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Background: The aim of this study was to collect, synthesize, and analyze the clinicdemographic data of rhabdomyosarcoma affecting the oral cavity of young children. Methods:The clinical question was "What are the clinical characteristics of oral rhabdomyosarcoma in children aged zero to two years?" Two independent reviewers selected the studies, extracted data, and assessed the methodological quality through the Joanna Briggs Institute Checklist. Descriptive statistics were performed in SPSS.(protocol: osf.io/b9hvy).Results: Thirty case reports with 41 patients were included (22 males; mean age at diagnosis: 15 months). All studies had some methodological limitations, mainly due to the lack of clarity for a final judgment. More than 70% of the cases affected the tongue or lips. Tumors had a fast growth (mean 2.5 months), usually with red coloration, and variable shape and consistency. Embryonal (63.41%) and alveolar (29.27%) were the most common histological subtypes. Treatment was quite variable but usually included surgery. Most patients (53.66%) were alive without disease at follow-up. Conclusion:Oral rhabdomyosarcoma is rare in children aged 0-2 years without a marked gender predilection. The tumor presents as a fast and infiltrative growth leading to local and/or systemic symptoms, and a favorable prognosis for most patients.

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Section: Discussionmentioning

confidence: 99%

Section: Methodological Qualitymentioning

confidence: 99%