2019
DOI: 10.1002/jcb.28451
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Molecular profile of ultrastructure changes of the ligamentum flavum related to lumbar spinal canal stenosis

Abstract: Lumbar spinal canal stenosis (LSCS) is a degenerative disease observed by hypertrophy of the ligamentum flavum (LF) that cause compression of the lumbar neural content. Diabetes mellitus (DM) is a risk factor for the disease and we have shown previously that DM increases the fibrosis and elastic fiber loss in patients with LSCS. The purpose of this study was to find the proteins that play a role in the development of this clinical pathogenesis and the effect of DM on protein expression. LF tissue retrieved fro… Show more

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Cited by 10 publications
(20 citation statements)
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“…However, further research on the mechanism of this process is awaited. Similarly, the decreased expression of many other proteins such as collagen 6 and TGF inhibitor is found to be associated with increased levels and activation of M1 pro‐inflammatory pathways in LF of LSCS/DM 62 …”
Section: Risk Factors For Hypertrophymentioning
confidence: 89%
See 1 more Smart Citation
“…However, further research on the mechanism of this process is awaited. Similarly, the decreased expression of many other proteins such as collagen 6 and TGF inhibitor is found to be associated with increased levels and activation of M1 pro‐inflammatory pathways in LF of LSCS/DM 62 …”
Section: Risk Factors For Hypertrophymentioning
confidence: 89%
“…Similarly, the decreased expression of many other proteins such as collagen 6 and TGF inhibitor is found to be associated with increased levels and activation of M1 pro-inflammatory pathways in LF of LSCS/DM. 62 Recently, it is reported that the LF of DM patients exhibited higher levels of sorbitol. In vitro experiments, the high glucose-cultured fibroblasts exhibited significantly higher levels of sorbitol, inflammatory factors, and TGF-β1.…”
Section: Diabetes Mellitusmentioning
confidence: 99%
“…Extensive evidence has shown that genetic background (Hou et al, 2014;, mechanical stress (Hayashi et al, 2017;Shunzhi et al, 2017), aging and gender (Safak et al, 2010;Moon et al, 2015;Kim et al, 2018), endocrine and metabolic abnormalities (Dario et al, 2015;Shemesh et al, 2018;Chaput et al, 2019), local inflammation, and angiogenesis (Zhang K. et al, 2017;Sun et al, 2018;Yang et al, 2018a;Jezek et al, 2020) are potential predisposing factors in the development of HLF/OLF. In addition, intrinsic alterations in multiple cellular activities, growth factors, and molecular mediators have been implicated in this intricate process (Chao et al, 2016;Qu et al, 2016a;Sidon et al, 2019;Ye et al, 2019). However, the definitive pathogenesis remains largely unclear.…”
Section: Introductionmentioning
confidence: 99%
“…LFH results from ligamentum flavum tissue fibrosis brought about by inflammation and stress 3‐7 . Pathological LFH exhibits the loss of elastic fibers and an increase in collagen fibers, suggesting the fibrotic changes 3 . Several inflammatory cytokines, including transforming growth factor‐β1 (TGF‐β1), tumor necrosis factor‐α (TNF‐α), and IL‐6 (interleukin‐6), participate in this fibrotic process, which are reported to underlie the pathologic mechanism of LFH in a patient with LSS 4‐6 .…”
Section: Introductionmentioning
confidence: 99%
“…Ligamentum flavum hypertrophy (LFH) has been considered as a major cause of LSS development 2 . LFH results from ligamentum flavum tissue fibrosis brought about by inflammation and stress 3‐7 . Pathological LFH exhibits the loss of elastic fibers and an increase in collagen fibers, suggesting the fibrotic changes 3 .…”
Section: Introductionmentioning
confidence: 99%