Molecular Profiling

Alvaro, Domenico; Cardinale, Vincenzo

doi:10.1007/978-3-642-40558-7_7

Cited by 1 publication

(2 citation statements)

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“…Ras proteins (Kras, Nras, Hras, and Braf), responsible for signal transduction downstream to growth factor receptors, have been investigated largely in CCA. In this regard, KRAS-activating mutations represent one of the most frequent genetic alterations (up to 75% of CCA cases) [67]. When classified by tumor site, only 17% of peripheral-type CCAs (mixed-CCAs) were positive for KRAS mutations, whereas this occurs in more than 50% of the hilar-type CCA, that is, typically a mucin-CCA [67].…”

Section: Pbgs and Cholangiocarcinomamentioning

confidence: 99%

“…In this regard, KRAS-activating mutations represent one of the most frequent genetic alterations (up to 75% of CCA cases) [67]. When classified by tumor site, only 17% of peripheral-type CCAs (mixed-CCAs) were positive for KRAS mutations, whereas this occurs in more than 50% of the hilar-type CCA, that is, typically a mucin-CCA [67]. Thus, also molecular profiles underlie the similarities between mucin-producing cancers of the colon, pancreas, and biliary tree.…”

Section: Pbgs and Cholangiocarcinomamentioning

confidence: 99%

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Cholangiocarcinomas: New Insights from the Discovery of Stem Cell Niches in Peribiliary Glands of the Biliary Tree

Cardinale

Bragazzi

Carpino

et al. 2014

Advances in Hepatology

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Peribiliary glands (PBGs) are located in the large intrahepatic and extrahepatic bile ducts. Although they were described many years ago, their functions have been elucidated only in the last couple of years when our group demonstrated that PBGs are niches of multipotent stem/progenitor cells of endodermal origin. These cells express genes of multipotency and can be rapidly differentiatedin vitrointo hepatocytes, cholangiocytes, and endocrine pancreatic cells. PBGs share common features, in terms of stem/progenitor cell niches, with pancreatic duct glands and colon crypts, glandular structures representing in the adult life the endodermal remnants of fetal life. PBG stem/progenitor cells participate in the renewal of surface biliary epithelium and are active players in chronic pathologies of the biliary tree as well as in cholangiocarcinomas (CCA). Specifically, a large amount of recent evidence indicates that the pure mucin-CCA originates from PBGs; this could explain the similarities with pancreatic ductal adenocarcinoma and colorectal cancer, which also originate from transformed gland cells. In this paper, we summarized our recent findings concerning structure and functions of PBGs with the implications for liver pathophysiology and, specifically, for cancers of the biliary tree.

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Section: Pbgs and Cholangiocarcinomamentioning

confidence: 99%

Section: Pbgs and Cholangiocarcinomamentioning

confidence: 99%