1998
DOI: 10.1159/000025315
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Molecular Profiling of Tyrosine Kinases in Normal and Cancer Cells

Abstract: As the post-genome era is approaching, with vast amount of sequence information available and new technology developed, scientists are presented with opportunities to explore in simple analysis the structure and expression pattern of not just a single gene, but of an entire family of genes, if not the entire genome. The concept of ‘molecular profiling’ or ‘expression array’ has thus emerged. The need to simultaneously ‘see’ all genes in the same family is obvious under the precept of the combinatorial process … Show more

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Cited by 2 publications
(3 citation statements)
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“…Because aberrant RTK signaling plays a role in the development of some cancers, RTKs have been important targets for anticancer treatments [17][18][19][20][21]. Receptor tyrosine kinases (RTKs) are important in controlling cellular proliferation.…”
Section: Introductionmentioning
confidence: 99%
“…Because aberrant RTK signaling plays a role in the development of some cancers, RTKs have been important targets for anticancer treatments [17][18][19][20][21]. Receptor tyrosine kinases (RTKs) are important in controlling cellular proliferation.…”
Section: Introductionmentioning
confidence: 99%
“…of seal lymphocytes to model compounds, could be identified via RT-PCR and restriction enzyme digest analysis. This technique has been applied previously to human samples to characterize kinase expression in disease (Robinson et al, 1996;Kung et al, 1998;Mao et al, 2002). In this approach, subsamples of labeled DNA (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…Various protein kinase transcripts were PCR-amplified using degenerate primers derived from the conserved motifs DFG (5 0 ) and DVW (3 0 ) within the catalytic domains of (human) PTK. These have been described in detail previously (Robinson et al, 1996;Kung et al, 1998;Lin et al, 1998). Briefly, DFG is present in virtually all kinases, whereas DVW is primarily encoded by tyrosine kinases, although a small number of serine kinases can also be primed.…”
Section: Rt-pcrmentioning
confidence: 99%