Molecular Properties of Lysine Dendrimers and their Interactions with Aβ-Peptides and Neuronal Cells

Nanotechnology Building Blocks for Intervention with Alzheimer’s Disease Pathology: Implications in Disease Modifying Strategies

“…of fluorescence-labelled D3 dendrimers to rat brain, dendrimers were found distributed to both parietal cortex and hippocampus, major regions involved in AD, without any sign of cell death throughout the brain [35].…”

“…Recently, minimally toxic dendrimers like poly-L lysine dendrimers D3 and D5 were found with strong anti-amyloid properties as demonstrated in human neuroblastoma SH-SY5Y cells. In addition, D3 lysine dendrimers, attenuated Aβ induced increases in K + channel current [35]. Interestingly, following intraventricular injection dendrimer-peptide ratios, the interaction of the PPI-G4-Mal dendrimer with the monomeric peptide does not prevent the fibrillization, but clumps fibrils.…”