Molecular psychiatry of zebrafish

Stewart, Adam; Ullmann, Jeremy F.P.; Norton, William; Parker, Matthew O.; Brennan, Caroline H.; Gerlai, Robert; Kalueff, Allan V.

doi:10.1038/mp.2014.128

Cited by 198 publications

(138 citation statements)

References 227 publications

(295 reference statements)

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“…The zebrafish has been proposed to model such disorders to facilitate discovery of their mechanisms and development of treatment (Kalueff et al, 2014;Stewart et al, 2015;Shams et al, 2018). However, this type of research suffers from an inherent paradox: in order for one to properly model the chosen human disorder, one has to first know its mechanism, the latter being the reason why the disease model would be created at the first place.…”

Section: Shoaling and The Dopaminergic System In Zebrafishmentioning

confidence: 99%

“…Moreover, the enormous diversity of behavioural and physiological adaptations in fish allows for these methods to be applied to questions on specific adaptations as well as general neurobehavioural trends. As a result, fish behaviour -especially stress-related and social behaviour -is increasingly being recognized as a tool in the neurosciences (Gerlai, 2014;Maximino et al, 2015;Stewart et al, 2015;Soares et al, 2017). A picture is emerging in which complex relationships between fish social behaviour and stress are becoming prominent, and special attention now is given to the applications of these relationships (Oliveira, 2013;Soares et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares

Maximino

2018

Preprint

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Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explored aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could "bridge" the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, we need neuroanatomical, pharmacological, behavioural, and ecological studies conducted in the laboratory and in nature.These areas need to add to each other to enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

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Section: Shoaling and The Dopaminergic System In Zebrafishmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares

Maximino

2018

Preprint

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“…Zebrafish is increasingly being considered as a model organism in behavioral research (Bonan & Norton, 2015;Kalueff et al, 2012;Norton & Bally-Cuif, 2010;Stewart et al, 2015), with a great deal of studies on alcohol (S. Tran et al, 2016). Behavioral effects of drug withdrawal have been demonstrated with different drugs, including cocaine (López-Patiño, Yu, Cabral, et al, 2008;López-Patiño, Yu, Yamamoto, et al, 2008) and morphine (Cachat et al, 2010;Khor et al, 2011;Wong et al, 2010); in all cases, the behavioral endpoint assessed was anxiety-like behavior.…”

Section: Cc-by-ndmentioning

confidence: 99%

“…Zebrafish (Danio rerio) species is increasingly being considered as useful model organisms for studying both behavioral genetics and behavioral neuroscience, neuropsychopharmacology, and neurotoxicology (Bonan & Norton, 2015;Kalueff et al, 2012;Norton & Bally-Cuif, 2010;Stewart et al, 2015). The main advantages associated with this species are its low cost of acquisition and upkeep, ease handling, short lifespan, and readiness of reproduction in laboratory environments (Gerlai, 2014;Kalueff, Echevarria, & Stewart, 2014).…”

Section: Introductionmentioning

confidence: 99%

Behavioral and biochemical effects of ethanol withdrawal in zebrafish

Chaves

Felicio

Costa

et al. 2017

Preprint

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Chronic alcohol use induces adaptations and toxicity that can induce symptoms of anxiety, autonomic hyperarousal, and seizures when alcohol is removed (withdrawal syndrome).Zebrafish has recently gained wide attention as a behavioral model to study the neurobehavioral effects of acute and chronic alcohol use, including withdrawal. The literature, however, is very contradictory on findings regarding withdrawal effects, with some studies reporting increased anxiety, while others report no effect. A meta-analytic approach was taken to find the sources of this heterogeneity, and ethanol concentration during exposure and exposure duration were found to be the main sources of variation. A conceptual replication was also made using continuous exposure for 16 days in waterborne ethanol (0.5%) and assessing anxiety-like behavior in the light/dark test after 60 min withdrawal. Withdrawal was shown to reduce preference for darkness, consistent with decreased anxiety, but to increase risk assessment, consistent with increased anxiety. Animals were also subjected to the withdrawal protocol and injected with pilocarpine in a sub-convulsive dose to assess susceptibility to seizures. The protocol was sufficient to increase susceptibility to seizures in animals exposed to ethanol. Finally, withdrawal also decreased catalase activity in the brain, but not in the head kidney, suggesting that oxidative stress could be a mechanism associated with the behavioral effects of ethanol withdrawal.

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“…Moreover, the enormous diversity of behavioural and physiological adaptations in fish allows for these methods to be applied to questions on specific adaptations as well as general neurobehavioural trends. As a result, fish behaviour -especially stress-related and social behaviour -is increasingly being recognized as a tool in the neurosciences Maximino et al, 2015;Stewart et al, 2015;Soares et al, 2017). A picture is emerging in which complex relationships between fish social behaviour and stress are becoming prominent, and special attention now is given to the applications of these relationships (Oliveira, 2013;Soares et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares¹,

Maximino²

2018

Preprint

View full text Add to dashboard Cite

Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explorted aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could “bridge” the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, neuroanatomy, pharmacology, behavioural analysis, and ecology studies conducted in the laboratory and in nature need to add to each other and enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

show abstract

Molecular psychiatry of zebrafish

Cited by 198 publications

References 227 publications

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Behavioral and biochemical effects of ethanol withdrawal in zebrafish

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

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