Molecular rearrangements in the derivatives of grandiflorenic acid [(-)-kaura-9(11),16-diene-19-oic acid] and some related diterpenes

Cytostatic and Cytotoxic Activity of Synthetic Diterpene Derivatives Obtained from (-)-Kaur-9(11), 16-Dien-19-Oic Acid Against Human Cancer Cell Lines

“…All these compounds (1), (2), (3), (4a), (4b), (5), and (6) had physical and spectroscopic data identical to those reported by Nakano and co-worker [1,2,3].…”

“…Compound (2) inhibited cell proliferations with GI 50 at 4.17 µM against Breast cancer T47D, LC 50 = 39 µM, Log 10 GI 50 = -5.38. Compound (2) was active against all cell lines, with mean log 10 GI 50 values ranging from -4.80 non-small cell lung cancer NCI-H522 to -5.38 Breast cancer T47D. In addition, it showed GI 50 at 7.41 µM against CNS cancer SF-268, LC 50 = 27.8 µM, log 10 GI 50 = -5.13.…”

“…These synthetic diterpenes (1), (2) and (3) were evaluated for their antitumoral activity at DTP. The compound (1) inhibited cell proliferations with GI 50 values of 51.6 nM against CNS SF-539, LC 50 = 100 µM, log 10 GI 50 = -7.29.…”