Molecular recognition between adenine or 2,6-diaminopurine and copper(II) chelates with N,O2,S-tripodal tetradentate chelators having thioether or disulfide donor groups

Metal binding pattern of acyclovir in ternary copper(II) complexes having an S-thioether or S-disulfide NO2S-tripodal tetradentate chelator

“…H 2 BCBCÁ0.5H 2 O and H 4 TCCÁ3H 2 O acids were prepared as previously reported [4]. All other reagents are commercially available (Sigma-Aldrich, Acros) and were used as received.…”

“…1). These ligands were designed as NO 2 S-tripodal tetradentate chelators and form ternary Cu(II) complexes with purine nucleobases [4].…”

“…BCBC and TCC are known by long time [2]. However new synthetic methods were reported for H 2 BCBCÁ0.5H 2 O and H 4 TCCÁ3H 2 O [4]. Also the crystal structure of the polymer {[Cu 2 (l 4 -TCC)(H 2 O) 2 ]Á 4H 2 O} n was reported [5] and has been considered as the 'binary Cu (II)-TCC compound'.…”

“…Also the crystal structure of the polymer {[Cu 2 (l 4 -TCC)(H 2 O) 2 ]Á 4H 2 O} n was reported [5] and has been considered as the 'binary Cu (II)-TCC compound'. It reacts with imidazole (Him) [6], (5)-methylimidazole (H(5)Meim [7], with two tautomers), adenine (Hade), 2,2'-bipyridine (bpy) or 1,10-phenantroline (phen) [4] yielding molecular ternary compounds. Besides H 4 TCCÁ3H 2 O, only [Cu 2 (BCBC) 2 (l-N3,N7-H(N9)ade)(H 2 O) 2 ]ÁH 2 O and [Cu 2 (BCBC) 2 (l-N7,N9-H(N3)dap)(H 2 O) 2 ]Á4H 2 O have been structurally characterized [4] with purine ligands two different tautomers [8].…”

Novel Cd (II) Coordination Polymers Afforded with EDTA or Trans-1,2-Cdta Chelators and Imidazole, Adenine, or 9-(2-Hydroxyethyl) Adenine Coligands

“…For a long time, we have been interested in the investigation of molecular recognition modes between copper(II) chelates and amino-purine bases (such as adenine, 2-aminopurine, 2,6-diaminopurine, and hypoxanthine) [3][4][5][6][7][8][9][10][11][12][13]. Our work also includes deaza-and aza-purines and closely related N-heterocycles, related to at least one N atom in each five-or six-membered rings of the purine skeleton [5].…”