2018
DOI: 10.1007/s00018-018-2749-4
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Molecular recognition of microbial lipid-based antigens by T cells

Abstract: The immune system has evolved to protect hosts from pathogens. T cells represent a critical component of the immune system by their engagement in host defence mechanisms against microbial infections. Our knowledge of the molecular recognition by T cells of pathogen-derived peptidic antigens that are presented by the major histocompatibility complex glycoproteins is now well established. However, lipids represent an additional, distinct chemical class of molecules that when presented by the family of CD1 antige… Show more

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Cited by 13 publications
(5 citation statements)
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“…The relationship between humans and microbes is multifaceted: even if the vast majority of microorganisms are innocuous and beneficial to the host, some microorganisms can shift towards a pathogenic phenotype, defined as pathobiont [156,159], able to adhere to the host, invade underlying tissues and multiply thus evading host immune defenses [160]. The host responds to pathogens or pathogen-associated molecular patterns (PAMPs) producing inflammatory mediators, which, in turn, recruit mature neutrophils releasing granules-contained Lf in the sites of infection [25,161].…”
Section: Lactoferrin Against Septic Inflammationmentioning
confidence: 99%
“…The relationship between humans and microbes is multifaceted: even if the vast majority of microorganisms are innocuous and beneficial to the host, some microorganisms can shift towards a pathogenic phenotype, defined as pathobiont [156,159], able to adhere to the host, invade underlying tissues and multiply thus evading host immune defenses [160]. The host responds to pathogens or pathogen-associated molecular patterns (PAMPs) producing inflammatory mediators, which, in turn, recruit mature neutrophils releasing granules-contained Lf in the sites of infection [25,161].…”
Section: Lactoferrin Against Septic Inflammationmentioning
confidence: 99%
“…Type I iNKT cells possess TCR α-chains encoding fixed TRAV–TCR α-chain J (TRAJ) rearrangements (TRAV18/TRAJ10 in humans), which pair with TCR β-chains displaying limited TRBV gene usage, whilst type II NKT cells possess more polyclonal TCR repertoires composed of cells expressing αβ, γδ, or δ/αβ TCRs [ 24 , 33 , 150 , 151 , 152 , 153 ]. Microbial lipid antigens that are structurally similar to α-galactosylceramide, a glycolipid from the marine sponge Agelas mauritianus [ 154 ], are potent ligands for type I iNKT cells [ 24 , 153 ], but not type II NKT cells [ 150 , 151 ]. Type I iNKT cells respond rapidly to antigen and exist in diverse subsets defined by their effector cytokine production and transcription factor profile [ 24 ].…”
Section: How T Cells Fight Bacteriamentioning
confidence: 99%
“…Cleavage of these membrane lipids may produce mediators capable of interacting with and modulating melanoma cells. It is widely accepted that bacterial lipids can be recognized by adaptive T and NK cells during antigen binding on the CD1 receptor [61]. Additionally, studies indicate they can be recognized by other eukaryotic and mammalian receptors including GPCRs [41, 62].…”
Section: Discussionmentioning
confidence: 99%