Molecular recognition of naphthalenediamine by polyamine modified β-cyclodextrin:yttrium metal complexes

Abstract

The 6-OH group of b-cyclodextrin was modified by diethylene triamine and triethylene tetramine, respectively, mono[6-diethylenetriamino]-6-deoxy-b-cyclo dextrin (DTCD) and mono[6-triethylenetetraamino]-6-deoxy-b-cyclodextrin (TTCD) were synthesized, which included 1,5-naphthalenediamine and 1,8-naphthalenediamine, respectively, in the presence of rare earth metal yttrium chloride. As a result, four ternary inclusion complexes (host-guest-metal) formed, which were characterized via 1 HNMR spectroscopy. The chemical shift variations of host and guest molecules were studied. The stoichiometric proportion of host and guest molecules is 2:1 for all the complexes. Signal degeneration still exists for the guest molecules after the inclusion process, which verifies the symmetrical conformation of guest molecules inside the cavities of two host molecules. All the four complexes exhibit ''sandwich''-typed structure.

A dual‐stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti‐colorectal drug hydroxycamptothecin

“…PEHA‐β‐CDs were synthesized according to the previous literature 32 . The synthetic route is shown in Figure S2.…”

“…PEHA-β-CDs were synthesized according to the previous literature. 32 The synthetic route is shown in Figure S2. PEHA-β-CD powder was obtained with a yield of 45.3%.…”