Molecular regulation of hematopoietic stem cell quiescence

Chen, Zhe; Guo, Qin; Song, Guanbin; Hou, Yu

doi:10.1007/s00018-022-04200-w

Cited by 21 publications

(17 citation statements)

References 227 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HSPCs maintain the stem cell pool through self‐renewal, differentiation, and programmed death to meet the body's demand for various blood cells. A number of factors are known to control HSPC homeostasis, such as Wnt and Notch signaling molecules, miRNAs, inflammatory factors, epigenetic factors, and cell cycle regulators (Walker et al , 1999; Reya et al , 2003; Jiang et al , 2019; Sezaki et al , 2020; Chen et al , 2022; Crisafulli & Ficara, 2022). For example, high level of Wnt signaling promotes HSPC proliferation and inhibits cell differentiation (Reya et al , 2003).…”

Section: Discussionmentioning

confidence: 99%

HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells

Yang,

Liu,

Yin

et al. 2023

EMBO Reports

View full text Add to dashboard Cite

Hematopoietic stem and progenitor cells (HSPCs) are cells mainly present in the bone marrow and capable of forming mature blood cells. However, the epigenetic mechanisms governing the homeostasis of HSPCs remain elusive. Here, we demonstrate an important role for histone deacetylase 6 (HDAC6) in regulating this process. Our data show that the percentage of HSPCs in Hdac6 knockout mice is lower than in wild‐type mice due to decreased HSPC proliferation. HDAC6 interacts with isocitrate dehydrogenase 1 (IDH1) and deacetylates IDH1 at lysine 233. The deacetylation of IDH1 inhibits its catalytic activity and thereby decreases the 5‐hydroxymethylcytosine level of ten‐eleven translocation 2 (TET2) target genes, changing gene expression patterns to promote the proliferation of HSPCs. These findings uncover a role for HDAC6 and IDH1 in regulating the homeostasis of HSPCs and may have implications for the treatment of hematological diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells

Yang,

Liu,

Yin

et al. 2023

EMBO Reports

View full text Add to dashboard Cite

show abstract

“…To use MECL lacking phenotypic markers or physically conjoined with vascular structures to identify novel cell proliferation pathways or cell cycle regulators. As a subset of morphologically distinct and non-disrupted MECL is completely devoid of the expression tumor suppressors, phenotypic and proliferation specific markers (Figure 11) or is physically conjoined with vascular structures (Figure 14), it is likely that these ME cells are derived from or regulated by a previously unidentified mechanism or pathway [192][193][194][195][196][197][198][199]. Thus, microdissection of these MECL for the gene expression profiling may lead to the identification of a novel cell proliferation pathway and cell cycle regulators.…”

Section: Specific Applications Of Mecl In Detection and Interventions...mentioning

confidence: 99%

The most likely but largely ignored triggering factor for breast (or all) cancer invasion

Man¹,

Mannion²,

Stojadinovic³

et al. 2023

J. Cancer

View full text Add to dashboard Cite

Breast cancer development and progression are believed to be a sequential process, from normal to hyperplastic, to in situ , and to invasive and metastatic stages. Given that over 90% of cancer deaths are caused by invasive and metastatic lesions, countless factors and multiple theories have been proposed as the triggering factor for the cascade of actions of cancer invasion. However, those factors and theories are largely based on the studies of cell lines or animal models. In addition, corresponding interventions based on these factors and theories have failed to reduce the incidence rate of invasive and metastatic lesions, suggesting that previous efforts may have failed to arm at the right target. Considering these facts and observations, we are proposing “A focal aberrant degeneration in the myoepithelial cell layer (MECL) as the most likely triggering factor for breast cancer invasion”. Our hypothesis is based on our recent studies of breast and multiple other cancers. Our commentary provides the rationale, morphologic, immunohistochemical, and molecular data to support our hypotheses. As all epithelium-derived cancers share a very similar architecture, our hypothesis is likely to be applicable to invasion of all cancer types. We believe that human tissue-derived data may provide a more realistic roadmap to guide the clinic practice.

show abstract

“…19 In quiescent stem cells, DNA methylation has been found to be important for the maintenance of stem cell properties and the regulation of cell cycle progression. 20 For example, DNA methylation has been shown to regulate the expression of key cell cycle regulators such as cyclin D and p21, which are important for the transition from quiescence to proliferation. 21 Another important epigenetic modification in quiescent stem cells is histone modification.…”

Section: Epigenetics Modifications In Quiescent Stem Cellsmentioning

confidence: 99%

The Epigenetic Regulation of Quiescent in Stem Cells

Radak,

Fallahi

2023

Glob Med Genet

View full text Add to dashboard Cite

This review article discusses the epigenetic regulation of quiescent stem cells. Quiescent stem cells are a rare population of stem cells that remain in a state of cell cycle arrest until activated to proliferate and differentiate. The molecular signature of quiescent stem cells is characterized by unique epigenetic modifications, including histone modifications and deoxyribonucleic acid (DNA) methylation. These modifications play critical roles in regulating stem cell behavior, including maintenance of quiescence, proliferation, and differentiation. The article specifically focuses on the role of histone modifications and DNA methylation in quiescent stem cells, and how these modifications can be dynamically regulated by environmental cues. The future perspectives of quiescent stem cell research are also discussed, including their potential for tissue repair and regeneration, their role in aging and age-related diseases, and their implications for cancer research. Overall, this review provides a comprehensive overview of the epigenetic regulation of quiescent stem cells and highlights the potential of this research for the development of new therapies in regenerative medicine, aging research, and cancer biology.

show abstract

Molecular regulation of hematopoietic stem cell quiescence

Cited by 21 publications

References 227 publications

HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells

HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells

The most likely but largely ignored triggering factor for breast (or all) cancer invasion

The Epigenetic Regulation of Quiescent in Stem Cells

Contact Info

Product

Resources

About