Molecular regulation of kidney development: is the answer blowing in the Wnt?

Merkel, Calli E.; Karner, Courtney M.; Carroll, Thomas J.

doi:10.1007/s00467-007-0504-4

Cited by 79 publications

(94 citation statements)

References 109 publications

(128 reference statements)

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“…In each case, Wnt signals are crucial for the induction and morphogenesis of these tubular assemblies. [17][18][19][20][21][22][23][24][25][26][27][28][29] Although Wnt signaling requirements in kidney formation are accepted, 2,[41][42][43][44][45][46][47][48]82 understanding the relative contributions of varying Wnt components and trajectories remains a key question. For example, 8 -10,14,15 However, involvement of PCP effectors that regulate actin dynamics have not yet been studied in kidney formation or in tubulogenesis.…”

Section: Discussionmentioning

confidence: 99%

Pronephric Tubulogenesis Requires Daam1-Mediated Planar Cell Polarity Signaling

Miller

Canny

Jang

et al. 2011

Journal of the American Society of Nephrology

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Canonical ␤-catenin-mediated Wnt signaling is essential for the induction of nephron development. Noncanonical Wnt/planar cell polarity (PCP) pathways contribute to processes such as cell polarization and cytoskeletal modulation in several tissues. Although PCP components likely establish the plane of polarization in kidney tubulogenesis, whether PCP effectors directly modulate the actin cytoskeleton in tubulogenesis is unknown. Here, we investigated the roles of Wnt PCP components in cytoskeletal assembly during kidney tubule morphogenesis in Xenopus laevis and zebrafish. We found that during tubulogenesis, the developing pronephric anlagen expresses Daam1 and its interacting Rho-GEF (WGEF), which compose one PCP/noncanonical Wnt pathway branch. Knockdown of Daam1 resulted in reduced expression of late pronephric epithelial markers with no apparent effect upon early markers of patterning and determination. Inhibiting various points in the Daam1 signaling pathway significantly reduced pronephric tubulogenesis. These data indicate that pronephric tubulogenesis requires the Daam1/WGEF/Rho PCP pathway.

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Section: Discussionmentioning

confidence: 99%

Pronephric Tubulogenesis Requires Daam1-Mediated Planar Cell Polarity Signaling

Miller

Canny

Jang

et al. 2011

Journal of the American Society of Nephrology

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“…Furthermore, defects in ciliary assembly may result in up-regulation of the canonical Wnt pathway and impair the ability of noncanonical Wnt signals to suppress the canonical pathway (Gerdes et al, 2007;Corbit et al, 2008). Altered regulation of the Wnt signaling pathway in the kidney has been associated with uncontrolled cell proliferation and differentiation and was found to result in cystic kidney disease (Cano et al, 2004;Merkel et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines

Nielsen

Møllgård

Clément

et al. 2008

Developmental Dynamics

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Hedgehog (Hh) signaling controls pancreatic development and homeostasis; aberrant Hh signaling is associated with several pancreatic diseases. Here we investigated the link between Hh signaling and primary cilia in the human developing pancreatic ducts and in cultures of human pancreatic duct adenocarcinoma cell lines, PANC-1 and CFPAC-1. We show that the onset of Hh signaling from human embryogenesis to fetal development is associated with accumulation of Hh signaling components Smo and Gli2 in duct primary cilia and a reduction of Gli3 in the duct epithelium. Smo, Ptc, and Gli2 localized to primary cilia of PANC-1 and CFPAC-1 cells, which may maintain high levels of nonstimulated Hh pathway activity. These findings indicate that primary cilia are involved in pancreatic development and postnatal tissue homeostasis.

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“…3 Using genetic mouse models, Wnt signaling has been shown to be functionally involved in different aspects of kidney development (reviewed in Ref. 4). During renal vesicle formation, Wnt9b expression in the ureteric bud is required for induction of the mesenchymal-epithelial transition of metanephric blastemal cells.…”

mentioning

confidence: 99%

Lineage Specification of Parietal Epithelial Cells Requires β-Catenin/Wnt Signaling

Grouls

Iglesias

Wentzensen

et al. 2012

Journal of the American Society of Nephrology

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b-Catenin/Wnt signaling is essential during early inductive stages of kidney development, but its role during postinductive stages of nephron development and maturation is not well understood. In this study, we used Pax8Cre mice to target b-catenin deficiency to renal epithelial cells at the late S-shaped body stage and the developing collecting ducts. The conditional b-catenin knockout mice formed abnormal kidneys and had reduced renal function. The kidneys were hypoplastic with a thin cortex; a superficial layer of tubules was missing. A high proportion of glomeruli had small, underdeveloped capillary tufts. In these glomeruli, well differentiated podocytes replaced parietal epithelial cells in Bowman's capsule; capillaries toward the outer aspect of these podocytes mimicked the formation of glomerular capillaries. Tracing nephrogenesis in embryonic conditional b-catenin knockout mice revealed that these "parietal podocytes" derived from precursor cells in the parietal layer of the S-shaped body by direct lineage switch. Taken together, these findings demonstrate that b-catenin/Wnt signaling is important during the late stages of nephrogenesis and for the lineage specification of parietal epithelial cells.

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Molecular regulation of kidney development: is the answer blowing in the Wnt?

Cited by 79 publications

References 109 publications

Pronephric Tubulogenesis Requires Daam1-Mediated Planar Cell Polarity Signaling

Pronephric Tubulogenesis Requires Daam1-Mediated Planar Cell Polarity Signaling

Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines

Lineage Specification of Parietal Epithelial Cells Requires β-Catenin/Wnt Signaling

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