Molecular Research and Treatment of Breast Cancer

Kawiak, Anna

doi:10.3390/ijms23179617

Cited by 23 publications

(7 citation statements)

References 14 publications

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“…Por exemplo, o gene BRCA1 está associado a fatores genéticos, e um histórico familiar dessa expressão genética pode indicar a necessidade de testes genéticos adicionais além da biópsia. A diversidade de tratamentos varia de acordo com o tipo específico de câncer de mama expressado pelo paciente (Kawiak A. 2022).…”

Section: Resultsunclassified

Desbravando Os Percursos Da Saúde Física, Mental E Social - Uma Abordagem Interdisciplinar

Rabi

2024

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Ao abrir as páginas deste livro, você está prestes a embarcar em uma jornada fascinante pelos intricados caminhos da saúde física, mental e social. Em "Desbravando os Percursos da Saúde Física, Mental e Social: Uma Abordagem Interdisciplinar", somos conduzidos por um percurso onde ciência e humanidade se entrelaçam para oferecer uma visão abrangente e holística da saúde.Neste volume, especialistas de diversas áreas se unem para explorar os múltiplos aspectos que compõem nosso bem-estar. Desde as nuances da saúde física, passando pela complexidade da saúde mental, até a importância das relações sociais, cada capítulo oferece insights valiosos e práticos para quem busca compreender e aprimorar sua qualidade de vida.Ao mergulhar nessas páginas, convidamos você a refletir, aprender e, acima de tudo, a agir. Pois a saúde é um tesouro que merece ser cuidado com zelo e sabedoria, e cada passo dado em direção ao equilíbrio e à plenitude é uma conquista a ser celebrada.

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Section: Resultsunclassified

Desbravando Os Percursos Da Saúde Física, Mental E Social - Uma Abordagem Interdisciplinar

Rabi

2024

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“…According to the most recent report on cancer statistics, breast cancer continues to be the most common tumor among women [56]. Because the occurrence and development tumors are regulated by complex molecular mechanisms, the choice of treatment options and disease prognosis of breast cancer are challenged at the molecular level [57]. USP32 was found to have an elevated copy number in estrogen receptor (ER) positive tumors, which is one of the 81 gene copy number traits that predict the metastatic capacity of breast cancer [58].…”

Section: Breast Cancermentioning

confidence: 99%

USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target

Li,

Song,

Wang

et al. 2023

Cell Death Discov.

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An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The substrate is modified by the ubiquitin ligase system (E1-E2-E3) in this pathway, which is a dynamic protein bidirectional modification regulation system. Deubiquitinating enzymes (DUBs) are tasked with specifically hydrolyzing ubiquitin molecules from ubiquitin-linked proteins or precursor proteins and inversely regulating protein degradation, which in turn affects protein function. The ubiquitin-specific peptidase 32 (USP32) protein level is associated with cell cycle progression, proliferation, migration, invasion, and other cellular biological processes. It is an important member of the ubiquitin-specific protease family. It is thought that USP32, a unique enzyme that controls the ubiquitin process, is closely linked to the onset and progression of many cancers, including small cell lung cancer, gastric cancer, breast cancer, epithelial ovarian cancer, glioblastoma, gastrointestinal stromal tumor, acute myeloid leukemia, and pancreatic adenocarcinoma. In this review, we focus on the multiple mechanisms of USP32 in various tumor types and show that USP32 controls the stability of many distinct proteins. Therefore, USP32 is a key and promising therapeutic target for tumor therapy, which could provide important new insights and avenues for antitumor drug development. The therapeutic importance of USP32 in cancer treatment remains to be further proven. In conclusion, there are many options for the future direction of USP32 research.

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“…The complexity of the molecular mechanisms that regulate tumorigenesis and progression determines the heterogeneity of BRCA, and the choice of treatment regimen and disease prognosis is subject to this heterogeneity [ 4 ]. Molecular advances have allowed a deeper comprehension of the cellular pathways that control BRCA development, facilitating advances in identifying diagnostic markers and developing new therapeutic strategies [ 5 ]. The identification of new drugs for BRCA and the establishment of tools with accurate prognostic predictors for patients with BRCA are essential for guiding clinical management.…”

Section: Introductionmentioning

confidence: 99%

The therapeutic effect and targets of herba Sarcandrae on breast cancer and the construction of a prognostic signature consisting of inflammation-related genes

Yuan,

Lin,

Yang

et al. 2024

Heliyon

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Molecular Research and Treatment of Breast Cancer

Abstract: Breast cancer is the leading cause of cancer-related deaths in the female population [...]

Cited by 23 publications

References 14 publications

Desbravando Os Percursos Da Saúde Física, Mental E Social - Uma Abordagem Interdisciplinar

Desbravando Os Percursos Da Saúde Física, Mental E Social - Uma Abordagem Interdisciplinar

USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target

The therapeutic effect and targets of herba Sarcandrae on breast cancer and the construction of a prognostic signature consisting of inflammation-related genes

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