Molecular Self-Assembly of an Unusual Dinuclear Ruthenium(III) Complex Based on the Nucleobase Guanine

Abstract

The study of crystal structures based on complexes containing purine nucleobases is a significant research subject, mainly regarding the diagnosis and treatment of some diseases and the investigation of genetic mutations and biochemical structures in life sciences. We have obtained and characterized a new dinuclear ruthenium(III) complex based on guanine with the formula [{Ru(µ-Cl)(µ-gua)}2Cl4]·2H2O (1) (gua = guanine). 1 was characterized by means of Fourier transform infrared spectroscopy (FT–IR), scanning electron microscopy and energy dispersive X-ray analysis (SEM–EDX), single-crystal X-ray diffraction (XRD), Hirshfeld surface analysis and cyclic voltammetry (CV). The study of its electrochemical properties allowed us to investigate the presence of guanine molecules when linked to the ruthenium(III) ion in 1. The well-resolved voltammetric response together with the reliability and stability achieved through 1 could provide a step forward to developing new ruthenium-based platforms, devices and modified electrodes adequate to study this purine nucleobase.

Ferromagnetic Coupling and Single-Ion Magnet Phenomenon in Mononuclear Ruthenium(III) Complexes Based on Guanine Nucleobase

“…In 2, the two guanine molecules are pretty much planar and form an intramolecular angle between them of approximately 2.0(1) • . In 1 and 2, the C-C, C-N and C-O bond lengths of the guanine ligands are as previously reported for this molecule when coordinated through N9 to 4d/5d metal centers [10][11][12][13].…”

Ferromagnetic Coupling and Single-Ion Magnet Phenomenon in Mononuclear Ruthenium(Iii) Complexes Based on Guanine Nucleobase

“…In 2, the two guanine molecules are pretty much planar and form an intramolecular angle between them of approximately 2.0(1)°. In 1 and 2, the C-C, C-N and C-O bond lengths of the guanine ligands are as previously reported for this molecule when coordinated through N9 to 4d/5d metal centers [10][11][12][13]. In the crystal lattice of compound 1, adjacent [RuCl4(Hgua)(dmso)] units are connected through H-bonding interactions between carbonyl and amino groups of protonated guanine and dmso ligands, which generate one-dimensional motifs growing offshore the b crystallographic axis [O•••N distances covering the range ca.…”

Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems

“…To retard this process, at least until the drug has been effectively internalized into cells [29], a common, extensively used approach is based on the choice of metal coordinating ligands less susceptible to the displacement operated by water molecules. In addition, ligands to be preferred should be molecules able to favor the self-assembly of the final complex in solution and to protect the metal core [30][31][32][33][34][35].…”