Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

Sabbah, Michèle; Emami, Shahin; Redeuilh, Gérard; Julien, Sylvia; Prevost, Grégoire; Zimber, A.; Ouelaa, Radia; Bracke, Marc; Wever, Olivier De; Gespach, Christian

doi:10.1016/j.drup.2008.07.001

Cited by 291 publications

(215 citation statements)

References 199 publications

Supporting

Mentioning

204

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, it is clear that Src is also able to indirectly activate epidermal growth factor receptor. Epidermal growth factor receptor activation by GPCR agonists to intracellular components depends on protein kinase and Calcium (Sabbah et al, 2008). MAPK signaling pathway plays a crucial role in the cell cycling regulation, also its over-expression and activation is essential for progression of colorectal cancer (Chapnick et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Combined EGFR and c-Src Antisense Oligodeoxynucleotides Encapsulated with PAMAM Denderimers Inhibit HT-29 Colon Cancer Cell Proliferation

Nourazarian

Gholamhoseinian²,

Farajnia³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Colon cancer continues to be one of the most common cancers, and the importance and necessity of new therapies needs to be stressed. The most important proto-oncogen factors for colon cancer appear to be epidermal growth factor receptor, EGFR, and c-Src with high expression and activity leading to tumor growth and ultimately to colon cancer progression. Application of c-Src and EGFR antisense agents simultaneously should theoretically therefore have major benefit. In the present study, anti-EGFR and c-Src specific antisense oligodeoxynucleotides were combined in a formulation using PAMAM dendrimers as a carrier. Nano drug entry

show abstract

Section: Introductionmentioning

confidence: 99%

Combined EGFR and c-Src Antisense Oligodeoxynucleotides Encapsulated with PAMAM Denderimers Inhibit HT-29 Colon Cancer Cell Proliferation

Nourazarian

Gholamhoseinian²,

Farajnia³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…The major proteins implicated in the transcriptional repression of E-cadherin include the zinc finger proteins snail and slug, δEF, smad interacting protein 1, ZEB2, and a basic helixloop-helix (bHLH) protein called twist. Several signaling pathways are also reported to be associated with EMT, which lead to transcriptional and post-transcriptional induction of EMT transcription factors (23). In regard to the relationship between irradiation and EMT, Andarawewa et al reported that irradiation induced TGF-β-mediated EMT (24).…”

mentioning

confidence: 99%

Radiation induces epithelial-mesenchymal transition in colorectal cancer cells

Kawamoto

Yokoe²,

Tanaka³

et al. 2011

Oncol Rep

View full text Add to dashboard Cite

Abstract. Radiotherapy remains a major approach to adjuvant therapy for patients with advanced rectal cancer. Nevertheless, the effects of radiation on malignant processes have yet to be clarified. The aim of this study was to assess the biological effects of radiation on colorectal cancer (CRC) cells with special reference to epithelial-mesenchymal transition (EMT), a key developmental program often activated during cancer invasion and metastasis. We investigated the effect of radiation on two colorectal cancer cell lines, CaR1 and DLD1, assessing cell morphology, motility, migration and invasive ability. Expression of molecules associated with EMT was determined using RT-PCR, Western blotting, and immunofluorescence staining in control and irradiated cells. We also used real-time RT-PCR to examine the expression of molecules associated with EMT before and after chemoradiotherapy. Thus, we studied 26 rectal cancer patients who received preoperative chemoradiotherapy followed by radical surgery. In addition, we examined the relationship between disease recurrence and the expression of a number of proteins. Irradiation caused CRC cells to undergo phenotypic changes characteristic of EMT: spindle-cell shape, loss of polarity, intercellular separation and pseudopodia formation. Irradiation enhanced cell migration and invasiveness. In irradiated CRC cells, molecular changes consistent with EMT were observed. In clinical samples, we observed molecular changes consistent with EMT, and those changes were significantly enhanced in patients with recurring disease. These results indicate that irradiation induces an alteration to a malignant phenotype consistent with EMT in colorectal cancer cells.

show abstract

“…These cell type configurations are linked to drug resistance. 81,[88][89][90][91][92] CSC are defined by their ability to undergo selfrenewal as well as multilineage differentiation and have been identified in a variety of tumor entities. [93][94][95][96] Ji et al demonstrated that overexpression of miRNA-34 provokes an 87% reduction of CD44þ/CD133þ CSC in PC cells, accompanied by significant inhibition of PC cell growth in vitro and tumor formation in vivo as well as sensitization of chemoresistant PC cells to gemcitabine.…”

Section: Micrornas As Epigenetic Targetsmentioning

confidence: 99%

Epigenetic markers for chemosensitivity and chemoresistance in pancreatic cancer—A review

Dhayat

Mardin

Mees

et al. 2011

Intl Journal of Cancer

View full text Add to dashboard Cite

Adjuvant first-line gemcitabine monochemotherapy presents a standard treatment for patients with advanced pancreatic adenocarcinoma and improves overall survival in chemosensitive patients. Nonetheless, 6-month progression-free survival remains below 15%, despite interdisciplinary approaches. The success of gemcitabine treatment is disappointing and-in the absence of reliable tumor markers-challenging to quantify. Epigenetic alterations have been recently identified to take on important roles in cancer development and possibly cancer treatment. In this context, microRNAs are becoming increasingly acknowledged as useful biomarkers for classifying cancers and providing information on their chemo-and radiosensitivity. This review illustrates the potential of genetic and epigenetic markers in the prediction of chemosensitivity in pancreatic cancer patients and in the monitoring of their response rates to adjuvant therapy.

show abstract

Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

Cited by 291 publications

References 199 publications

Combined EGFR and c-Src Antisense Oligodeoxynucleotides Encapsulated with PAMAM Denderimers Inhibit HT-29 Colon Cancer Cell Proliferation

Combined EGFR and c-Src Antisense Oligodeoxynucleotides Encapsulated with PAMAM Denderimers Inhibit HT-29 Colon Cancer Cell Proliferation

Radiation induces epithelial-mesenchymal transition in colorectal cancer cells

Epigenetic markers for chemosensitivity and chemoresistance in pancreatic cancer—A review

Contact Info

Product

Resources

About