Molecular Signatures in Urologic Tumors

Larkin, Spencer; Kyprianou, Natasha

doi:10.3390/ijms140918421

Cited by 5 publications

(3 citation statements)

References 63 publications

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“…The patients with the invasive diseases display a high risk of the progression and commonly the poor prognosis. To date, TP53 mutation [1], p27Kip1 [1,2], surviving [3], EFGRs [4], Integrin-linked kinase [5] and several microRNAs [6] have been identified to be related to the progression and the unfavorable outcome of the muscle-invasive tumors. Owing to the heterogeneity of the property of bladder cancer, the treatment of the invasive and the advanced TCCs remains a clinical challenge.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic targeting Netrin-1-positive invasive bladder cancer cells with oridonin

Meng¹,

Li²,

Sun³

et al. 2020

Preprint

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Background Small compound oridonin acts as an effective anti-tumor agent used for a wide variety of human malignancies, while the antitumor efficacy and molecular mechanism of oridonin against bladder cancer remains unclear. Methods Four independent cohorts of bladder cancer were employed to assess the correlation between netrin-1 expression and progression and prognosis of bladder cancer. Clinical potential of netrin-1 as a biomarker and oridonin-mediated netrin-1-targeting anti-tumor mechanism were investigated by QRT-PCR, Western blot and ELISA. Regulatory mechanisms of Netrin-1 were investigated by luciferase reporter assay and Western blot. The EJ-inoculated nude mice xenograft model was used for the in vivo study. Results High expression of netrin-1 was significantly correlated with a poor overall survival in three independent bladder cancer cohorts. Urinary netrin-1 level was significantly elevated in bladder cancer patients correlating with tumor invasion and grade. Netrin-1 promoted cell proliferation, tumorsphere-forming, migration and invasion in bladder cancer cells. Oridonin treatment strikingly suppressed these malignant phenotypes and induced cell death in TCC cell lines and murine xenografts. Oridonin markedly decreased netrin-1 through inhibiting NF-κB transcriptional activity and shortening the half-life of NTN1 mRNA via inducing IRE1α, resulting in repression of its downstream signaling. Conclusions Together, these results strongly suggest that netrin-1 promotes the progression of bladder cancer, and acts as a potential urinary biomarker for the diagnosis as well as the prediction of the tumor progression. Oridonin exerts its strong anti-tumor activity against the invasive bladder cancer by suppressing netrin-1 mRNA production and stability.

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Section: Introductionmentioning

confidence: 99%

Therapeutic targeting Netrin-1-positive invasive bladder cancer cells with oridonin

Meng¹,

Li²,

Sun³

et al. 2020

Preprint

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“…Recently an increased number of articles have reported hundreds of genes and proteins which are related to RC. Many were suggested as potential disease biomarkers, such as VEGFA, IL6, and MIR34A [5][6][7] . Some genes, such as, IL2, have been studied in clinical trials [8] .…”

Section: Introductionmentioning

confidence: 99%

Literature Data Mining and Enrichment Analysis Reveal A Genetic Network of 423 Genes for Renal Cancer

Zhou¹,

Wang²,

Cao³

et al. 2016

Med One

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Background: Renal cancer (RC) originates in the cells of the kidneys. Worldwide, approximately 208,500 new cases of renal cancer are diagnosed annually. This accounts for just under 2 % of all cancers. Those with a family history of RC have an increased risk of developing the disease. Recent research has identified hundreds of genes which may relate to its development. No study has systematically summarized these findings or provided an objective view of the genes reportedly associated with RC. Methods: Literature data mining (LDM) was performed on more than 1,100 articles for publications between 1988 and April 2016 in which 423 genes were reported to be RC-associated. A gene set enrichment analysis (GSEA) and a sub-network enrichment analysis (SNEA) were performed to study the functional profile and pathogenic significance of these genes. A network connectivity analysis (NCA) to study the associations between the reported genes was done. Literature, and enrichment metrics, analyses were used to identify genes with specific RC significance. Results: Multiple RC associations for 329 of the 423 genes enriched 100 pathways (p < 1.2e-10) were demonstrated. Ten genes (IL6,

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“…Bu mutasyonlar sonucunda genin ürününün aşırı üretimi meydan gelmekte ve hücre çoğalması hızlanmaktadır. Kİ-ÜRK'ların moleküler yolağında ise hücre siklus kontrolünden sorumlu olan TP53, p16 ve RB gibi tümör süpresör genlerdeki mutasyonlar primer sorumludur(12,49,50). Bir tümör süpresör gen olan ve 17p13.1 de yer alan TP53 geni hücre siklusunda G1/S geçişinde anahtar rol oynayan DNA tamirini ve apoptozu düzenleyen bir protein kodlar(13).…”

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Diagnostic and Prognostic Molecular Features of Urothelial Bladder Cancer and New Treatment Approaches

Küçükodacı¹,

Yörükoğlu²

2015

uob

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Molecular Signatures in Urologic Tumors

Cited by 5 publications

References 63 publications

Therapeutic targeting Netrin-1-positive invasive bladder cancer cells with oridonin

Therapeutic targeting Netrin-1-positive invasive bladder cancer cells with oridonin

Literature Data Mining and Enrichment Analysis Reveal A Genetic Network of 423 Genes for Renal Cancer

Diagnostic and Prognostic Molecular Features of Urothelial Bladder Cancer and New Treatment Approaches

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