Molecular Signatures of Chronic Pain Subtypes

Abstract

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThis project continues to be a biomarker discovery program focusing on the causes of persistent pain after traumatic amputation in the combat setting. In the second year we have: 1) maintained the necessary regulatory approval at WRMC and Duke University. We have obtained and maintained documents for approval by MRMC; 2) maintained our interactive, secure web based data collection system; 3) populated our biorepository at Duke with bioresource collected from 71 patients enrolled at WRNMMC; 4) conducted further on-site visits and investigator meetings at WRNMMC; 5) submitted samples to the Duke Core Lab facilities for proteomic, metabolomic, genomic, genetic and epigenetic assays. We have received our initial pilot results and presented these in Washington DC at ASA. We have published two more papers and are now collecting our validation cohort of patients. Our overall progress is slightly ahead of target, given the lengthy administrative delays during year one. Lastly, we have been funded by DOD to conduct an intervention trial at WRNMMC and the Durham VAMC of valproate for the prevention of amputation induced chronic pain.