Molecular structure dependence of acoustic nonlinearity parameter
                    <i>B/A</i>
                    for silicone oils

Zhang, Zhe; Gong, Chen; Zhang, Dong

doi:10.1088/1674-1056/23/5/054302

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…It has been reported in the previous literature that the resonance frequency of the encapsulated microbubble can be raised when increasing the shell elasticity, [34,40] which accords well with the present numerical results shown in Fig. 5(a).…”

Section: Effects Of Bubble Shell Visco-elastic Properties On Microstr...supporting

confidence: 93%

Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane

Li¹,

Tu²,

Guo³

et al. 2014

Chinese Phys. B

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Sonoporation mediated by microbubbles is being extensively studied as a promising technology to facilitate gene/drug delivery to cells. However, the theoretical study regarding the mechanisms involved in sonoporation is still in its infancy. Microstreaming generated by pulsating microbubble near the cell membrane is regarded as one of the most important mechanisms in the sonoporation process. Here, based on an encapsulated microbubble dynamic model with considering nonlinear rheological effects of both shell elasticity and viscosity, the microstreaming velocity field and shear stress generated by an oscillating microbubble near the cell membrane are theoretically simulated. Some factors that might affect the behaviors of microstreaming are thoroughly investigated, including the distance between the bubble center and cell membrane (d), shell elasticity (χ), and shell viscosity (κ). The results show that (i) the presence of cell membrane can result in asymmetric microstreaming velocity field, while the constrained effect of the membrane wall decays with increasing the bubble-cell distance; (ii) the bubble resonance frequency increases with the increase in d and χ, and the decrease in κ, although it is more dominated by the variation of shell elasticity; and (iii) the maximal microstreaming shear stress on the cell membrane increases rapidly with reducing the d, χ, and κ. The results suggest that microbubbles with softer and less viscous shell materials might be preferred to achieve more efficient sonoporation outcomes, and it is better to have bubbles located in the immediate vicinity of the cell membrane.

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Section: Effects Of Bubble Shell Visco-elastic Properties On Microstr...supporting

confidence: 93%

Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane

Li¹,

Tu²,

Guo³

et al. 2014

Chinese Phys. B

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show abstract

“…Ultrasound contrast agent (UCA) is usually comprised of suspensions of gas-filled microbubbles with micrometer diameters encapsulated by a thin stabilization coating (e.g., lipid, albumin, or polymer). [2,3] UCAs were initially used in ultrasound medical applications to enhance acoustic contrast between blood and surrounding tissues and thereby to improve the quality of ultrasonic images. Besides enhancing the reflection of ultrasound, the UCA microbubbles also exhibit nonlinear vibrations under insonation, which will produce harmonic, sub-harmonic, and ultra-harmonic responses.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles

Fan

et al. 2014

Chinese Phys. B

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Simulation study on practical choices for B / A measurement by the generalized finite amplitude insert-substitution method

Panfilova

Sloun

Wijkstra

et al. 2021

2021 IEEE International Ultrasonics Symposium (IUS)

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Molecular structure dependence of acoustic nonlinearity parameter B/A for silicone oils

Abstract: Molecular structure dependence of acoustic nonlinearity parameter B/A for silicone oils *Zhang Zhe(张喆) a) , Chen Gong(陈功) b) , and Zhang Dong(章东) a) † a)

Cited by 5 publications

References 20 publications

Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane

Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane

Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles

Simulation study on practical choices for B / A measurement by the generalized finite amplitude insert-substitution method

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Molecular structure dependence of acoustic nonlinearity parameter B/A for silicone oils

Abstract: Molecular structure dependence of acoustic nonlinearity parameter B/A for silicone oils *Zhang Zhe(张 喆) a) , Chen Gong(陈 功) b) , and Zhang Dong(章 东) a) † a)

Cited by 5 publications

References 20 publications

Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane

Microstreaming velocity field and shear stress created by an oscillating encapsulated microbubble near a cell membrane

Investigation on the relationship between overpressure and sub-harmonic response from encapsulated microbubbles

Simulation study on practical choices for B / A measurement by the generalized finite amplitude insert-substitution method

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Product

Resources

About

Abstract: Molecular structure dependence of acoustic nonlinearity parameter B/A for silicone oils *Zhang Zhe(张喆) a) , Chen Gong(陈功) b) , and Zhang Dong(章东) a) † a)