Molecular structure of crepidioside a and isolipidiol fromCrepis multicaulis

Fazylova, A. S.; Турдыбеков, К. М.; Kadirberlina, G. M.; Рахимова, Б. Б.; Адекенов, С. М.

doi:10.1007/bf02236425

Cited by 5 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These are mainly luteolin derivatives, with luteolin itself (76) being the most common one, present in twenty-one species. Additionally, luteolin-7-O-glucoside (80) and luteolin 7-O-glucuronide (81) are present in several species, eighteen and thirteen, respectively, whereas luteolin 7-O-gentiobioside (82) and luteolin 4 -O-glucoside (83) occur in few cases. Among the flavonols, the most common one is quercetin (84), present in C. divaricata Boss.…”

Section: Flavonoidsmentioning

confidence: 99%

See 1 more Smart Citation

Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review

Badalamenti

Sottile

Bruno

2022

Plants

View full text Add to dashboard Cite

The genus Crepis L., included within the Asteraceae family, has a very wide distribution, expanding throughout the northern hemisphere, including Europe, northern Africa, and temperate Asia. This genus has a fundamental value from biodynamic and ecological perspectives, with the different species often being chosen for soil conservation, for environmental sustainability, and for their attraction towards pollinating species. Furthermore, various species of Crepis have been used in the popular medicine of several countries as medicinal herbs and food since ancient times. In most cases, the species is consumed either in the form of a decoction, or as a salad, and is used for its cardiovascular properties, as a digestive, for problems related to sight, for the treatment of diabetes, and for joint diseases. This literature review, the first one of the Crepis genus, includes publications with the word ‘Crepis’, and considers the single metabolites identified, characterised, and tested to evaluate their biological potential. The various isolated compounds, including in most cases sesquiterpenes and flavonoids, were obtained by extracting the roots and aerial parts of the different species. The secondary metabolites, extracted using traditional (solvent extraction, column chromatography, preparative thin layer chromatography, preparative HPLC, vacuum liquid chromatography), and modern systems such as ultrasounds, microwaves, etc., and characterised by mono- and bi- dimensional NMR experiments and by HPLC-MS, have a varied application spectrum at a biological level, with antimicrobial, antioxidant, antidiabetic, antitumor, antiviral, antiulcer, phytotoxic, and nutritional properties having been reported. Unfortunately, in vitro tests have not always been accompanied by in vivo tests, and this is the major critical aspect that emerges from the study of the scientific aspects related to this genus. Therefore, extensive investigations are necessary to evaluate the real capacity of the different species used in food, and above all to discover what the different plants that have never been analysed could offer at a scientific level.

show abstract

Section: Flavonoidsmentioning

confidence: 99%

“…tectorumPoland roots glucozaluzanin C (8), tectoroside(12), 16, 17, ixerin F (41), isolipidiol (46), 8-epi-isolipidiol-3-O-β-D-glucopyranoside (50)[94,95] Kazakh. aerial parts integrifolin (8-epi-desacylcynaropicrin) (4), 8-epi-isolipidiol (42)[81,96]…”

mentioning

confidence: 99%

Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review

Badalamenti

Sottile

Bruno

2022

Plants

View full text Add to dashboard Cite

show abstract

“…The HMBC experiment of 2 showed two distinct correlations, i.e., the anomeric proton (Glc H-1, δ 5.06) with C-3 (δ 80.9), and Glc H-4 (δ 5.69) with C-8′ (δ 172.3), which supported the connectivity between the glucose moiety with the 3-hydroxy group of the sesquiterpene skeleton and also the linkage point of the p-hydroxyphenylacetyl group on the G-4 position. Therefore, the structure of 2 was identified as 4′-p-hydroxyphenylacetyl crepiside E. The other purified components 3-10 were identified as isolipidiol (3) [12], isoamberboin (4) [13], grosheimin (5) [14], annuionone D (6) [15], loliolide (7) [16], youngiajaponicoside A (8) [17], crepiside H (9) [18], and crepiside E (10) [18] by direct comparison of their spectral data with those in the literature. All isolated compounds (1-10) from Y. japonica were examined for inhibitory effects on proliferative of human cancer cell lines A549 (nonsmall cell lung carcinoma), SK-OV-3 (ovary malignant ascites), SK-MEL-2 (skin melanoma), and HCT15 (colon adenocarcinoma), according to the SRB assay in vitro [19].…”

mentioning

confidence: 99%

Two Novel Guaiane Sesquiterpenes from the Whole Plant of Youngia japonica

et al. 2015

View full text Add to dashboard Cite

Two new guaiane-type sesquiterpenes (1 and 2) together with eight related sesquiterpenoidal constituents (3-10) were isolated from the whole extract of Youngia japonica. The chemical structures of 1-10 were established by spectroscopic analyses as 4-epi-isolipidiol (1), 4′-p-hydroxyphenylacetyl crepiside E (2), isolipidiol (3), isoambeboin (4), grosheimin (5), annuionone D (6), loliolide (7), youngiajaponicoside A (8), crepiside H (9), and crepiside E (10), respectively. Among the isolated components, 5 exhibited a significant inhibitory effect on the proliferation of cultured human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15).

show abstract

Bioprospecting of plant natural products in Schleswig-Holstein (Germany) I: chemodiversity of the Cichorieae tribe (Asteraceae) in Schleswig-Holstein

Zidorn

2019

Phytochem Rev

View full text Add to dashboard Cite

Molecular structure of crepidioside a and isolipidiol fromCrepis multicaulis

Cited by 5 publications

References 3 publications

Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review

Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review

Two Novel Guaiane Sesquiterpenes from the Whole Plant of Youngia japonica

Bioprospecting of plant natural products in Schleswig-Holstein (Germany) I: chemodiversity of the Cichorieae tribe (Asteraceae) in Schleswig-Holstein

Contact Info

Product

Resources

About