Molecular surveillance of Kelch-13 gene in Plasmodium falciparum field isolates from Mayurbhanj District, Odisha, India, and in silico artemisinin-Kelch-13 protein interaction study

Murmu, Laxman Kumar; Panda, Madhusmita; Meher, Biswa Ranjan; Purohit, Prasant; Behera, Jayantiprava; Barik, Tapan Kumar

doi:10.1007/s00436-023-07784-9

Cited by 1 publication

(2 citation statements)

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“…These changes make the parasite to varying degrees resistant to artemisinins, which are activated by hemoglobin breakdown products. [92][93][94][95][96] Besides kelch13, the resistance of ART is also associated with various other malaria parasite genes, such as RAD5, ferredoxin, tetratricopeptide, and nt1, with ARTÀ R. [97][98][99]…”

Section: Antimalarial Drug Resistance Due To Point Mutationsmentioning

confidence: 99%

“…According to a recent report by Birnbaum et al ., Kelch13 and related proteins make up an endocytic compartment that is linked to feeding on host erythrocytes and Kelch13 compartment proteins are necessary for the endocytosis of host hemoglobin through their inactivation. These changes make the parasite to varying degrees resistant to artemisinins, which are activated by hemoglobin breakdown products [92–96] . Besides kelch13, the resistance of ART is also associated with various other malaria parasite genes, such as RAD5 , ferredoxin , tetratricopeptide , and nt1 , with ART−R [97–99] …”

Section: Antimalarial Drug Resistance Due To Point Mutationsmentioning

confidence: 99%

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Transition Metal Complexes as Antimalarial Agents: A Review

et al. 2023

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In antimalarial drug development research, overcoming drug resistance has been a major challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine, sulfadoxine, and artemisinin are used to treat malaria. But increment in drug resistance has pushed researchers to find novel drugs to tackle drug resistance problems. The idea of using transition metal complexes with pharmacophores as ligands/ligand pendants to show enhanced antimalarial activity with a novel mechanism of action has gained significant attention recently. The advantages of metal complexes include tunable chemical/physical properties, redox activity, avoiding resistance factors, etc. Several recent reports have successfully demonstrated that the metal complexation of known organic antimalarial drugs can overcome drug resistance by showing enhanced activities than the parent drugs. This review has discussed the fruitful research works done in the past few years falling into this criterion. Based on transition metal series (3d, 4d, or 5d), the antimalarial metal complexes have been divided into three broad categories (3d, 4d, or 5d metal‐based), and their activities have been compared with the similar control complexes as well as the parent drugs. Furthermore, we have also commented on the potential issues and their possible solution for translating these metal‐based antimalarial complexes into the clinic.

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