Molecular targets of dietary agents for prevention and therapy of cancer

Aggarwal, Bharat B.; Shishodia, Shishir

doi:10.1016/j.bcp.2006.02.009

Cited by 1,552 publications

(1,161 citation statements)

References 195 publications

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“…NO is closely linked to the nuclear transcription factor κB (NF-κB) pathway, which is often viewed as a "critical component to bridge inflammation and cancer" (62,66,77). NF-κB is a redox-regulated transcription factor, normally found in the cytoplasm as part of an inactive complex, but when it is activated by free radicals, inflammatory stimuli, carcinogens, tumor promoters, endotoxins, and radiation, it moves from the cytoplasm to the nucleus where it induces the expression of more than 200 genes.…”

Section: Inflammation-sincementioning

confidence: 99%

“…These genes not only affect inflammation, they also are associated with apoptosis, proliferation, and metastasis (66). Many of the target genes activated by the NF-κB pathway are key components for the establishment of many aggressive cancers (77). Quercetin, a bioactive compound found in many foods as well as herbs and spices such as basil, cumin, and fennel, has been shown to inhibit the NF-κB pathway in vivo and in vitro (66,78).…”

Section: Inflammation-sincementioning

confidence: 99%

“…Comolada et al found discrepancies between in vivo and in vitro antiinflammatory effects in experimental models of rat colitis for quercetin and its glycosylated form (quercitrin), which is the form commonly found in the diet which may be due in part to quercetin's rapid absorption in the upper gastrointestinal tract before reaching effective concentrations at the target site, which was the colon (78). Other inhibitors of the NF-κB pathway include ursolic acid (found in basil and rosemary), gingerol (present in ginger), and curcumin at concentrations of 100 μmol, 5 μmol, and 40-60 μmol respectively (77,(79)(80)(81).…”

Section: Inflammation-sincementioning

confidence: 99%

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The role of herbs and spices in cancer prevention

Kaefer

Milner

2008

The Journal of Nutritional Biochemistry

410

254

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Historically herbs and spices have enjoyed a rich tradition of use for their flavor-enhancement characteristics and for their medicinal properties. The rising prevalence of chronic diseases worldwide and the corresponding rise in health care costs is propelling interest among researchers and the public for these food related items for multiple health benefits, including a reduction in cancer risk and modification of tumor behavior. A growing body of epidemiological and preclinical evidence points to culinary herbs and spices as minor dietary constituents with multiple anticancer characteristics. This review focuses on the anti-microbial, antioxidant, and anti-tumorigenic properties of herbs and spices, their ability to influence carcinogen bioactivation, and likely anticancer contributions. While culinary herbs and spices present intriguing possibilities for health promotion, more complete information is needed about the actual exposures to dietary components that are needed to bring about a response and the molecular target(s) for specific herbs and spices. Only after this information is obtained will it be possible to define appropriate intervention strategies to achieve maximum benefits from herbs and spices without eliciting ill-consequences.

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Section: Inflammation-sincementioning

confidence: 99%

Section: Inflammation-sincementioning

confidence: 99%

Section: Inflammation-sincementioning

confidence: 99%

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The role of herbs and spices in cancer prevention

Kaefer

Milner

2008

The Journal of Nutritional Biochemistry

410

254

View full text Add to dashboard Cite

show abstract

“…Others act as cancer suppressing agents, and can inhibit the development of cancerinitiated cells to pre-neoplastic and neoplastic cells [22,23]. However, in most cases, a given phytochemical can execute a multitude of intracellular effects, rather than a specific biological interaction, and the combination of these effects eventually facilitates cancer prevention/treatment [24,25]. Many phytochemicals are also found to modulate inflammation-related molecular targets [26,27].…”

Section: Introductionmentioning

confidence: 99%

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

Prasannan

Kalesh

Shanmugam

et al. 2012

Biochemical Pharmacology

128

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“…Oleuropein, the major polyphenolic constituent of olive oil, is another structurally different phenolic compound. [7] All these compounds have demonstrated a host of biological activities, displaying excellent antioxidant, [8,9] antitumor, [10,11] antiviral, [12] antimicrobial, [13] and anti-atherogenic [14,15] properties.…”

Section: Introductionmentioning

confidence: 99%

Combining Computational and Biochemical Studies for a Rationale on the Anti‐Aromatase Activity of Natural Polyphenols

et al. 2007

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Aromatase, an enzyme of the cytochrome P450 family, is a very important pharmacological target, particularly for the treatment of breast cancer. The anti‐aromatase activity of a set of natural polyphenolic compounds was evaluated in vitro. Strong aromatase inhibitors including flavones, flavanones, resveratrol, and oleuropein, with activities comparable to that of the reference anti‐aromatase drug aminoglutethimide, were identified. Through the application of molecular modeling techniques based on grid‐independent descriptors and molecular interaction fields, the major physicochemical features associated with inhibitory activity were disclosed, and a putative virtual active site of aromatase was proposed. Docking of the inhibitors into a 3D homology model structure of the enzyme defined a common binding mode for the small molecules under investigation. The good correlation between computational and biological results provides the first rationalization of the anti‐aromatase activity of polyphenolic compounds. Moreover, the information generated in this approach should be further exploited for the design of new aromatase inhibitors.

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Molecular targets of dietary agents for prevention and therapy of cancer

Cited by 1,552 publications

References 195 publications

The role of herbs and spices in cancer prevention

The role of herbs and spices in cancer prevention

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

Combining Computational and Biochemical Studies for a Rationale on the Anti‐Aromatase Activity of Natural Polyphenols

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