Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review

Doustmihan, Abolfazl; Fathi, Marziyeh; Mazloomi, MirAhmad; Salemi, Aysan; Hamblin, Michael R.; Jahanban-Esfahlan, Rana

doi:10.1016/j.jconrel.2023.09.029

Cited by 23 publications

(7 citation statements)

References 214 publications

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“…The results demonstrated the higher cellular uptake efficiency of HA-decorated N@Q compared to N@Q, confirming the HA role in the targeted delivery and its impact on increasing the therapeutic efficiency by possible targeting of CD44, which is a tumor marker of stem cell-like tumor cells (cancer stem cells). 2 Also, cellular uptake analyses of N@Q and HN@Q in HHF-2 as normal cells were similar, which confirmed the notion that HA coating has no beneficial effects on the uptake of NIO by the HHF-2 cells, which lack the CD44 receptor. 3.7.…”

Section: Drug Release Kineticssupporting

confidence: 68%

“…Drug protection from degradation by the reticuloendothelial system, enhanced uptake of drugs by target sites, and reduction of unwanted side effects with the aim to improve anticancer efficacy are goals pursued by the design of nanocarriers. , The stability of nanocarriers such as liposomes and niosomes (NIO) depends on the used lipids (e.g., cholesterol, l -α-soya phosphatidylcholine, etc.) in their structure .…”

Section: Introductionmentioning

confidence: 99%

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Hyaluronic Acid-Targeted Niosomes for Effective Breast Cancer Chemostarvation Therapy

Kaveh Zenjanab,

Abdolahinia,

Alizadeh

et al. 2024

ACS Omega

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Chemotherapy is widely used for cancer therapy; however, its efficacy is limited due to poor targeting specificity and severe side effects. Currently, the next generations of delivery systems with multitasking potential have attracted significant attention for cancer therapy. This study reports on the design and synthesis of a multifunctional nanoplatform based on niosomes (NIO) coloaded with paclitaxel (PTX), a chemotherapeutic drug commonly used to treat breast cancer, and sodium oxamate (SO), a glycolytic inhibitor to enhance the cytotoxicity of anticancer drug, along with quantum dots (QD) as bioimaging agents, and hyaluronic acid (HA) coating for active targeting. HN@QPS nanoparticles with a size of ∼150 nm and a surface charge of −39.9 mV with more than 90% EE for PTX were synthesized. Codelivery of SO with PTX remarkably boosted the anticancer effects of PTX, achieving IC 50 values of 1−5 and >0.5 ppm for HN@QP and HN@QPS, respectively. Further, HN@QPS treatment enhanced the apoptosis rate by more than 70% in MCF-7 breast cancer cells without significant cytotoxicity on HHF-2 normal cells. Also, quantification of mitochondrial fluorescence showed efficient toxicity against MCF-7 cells. Moreover, the cellular uptake evaluation demonstrated an improved uptake of HN@Q in MCF-7 cells. Taken together, this preliminary research indicated the potential of HN@QPS as an efficient targeted-dual drug delivery nanotheranostic against breast cancer cells.

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Section: Drug Release Kineticssupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Targeted Niosomes for Effective Breast Cancer Chemostarvation Therapy

Kaveh Zenjanab,

Abdolahinia,

Alizadeh

et al. 2024

ACS Omega

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“…On the other hand, this antigen is a protein that binds to the cell surface through the GPI interface, so its cell surface location can serve as a target for the development of cancer diagnosis and treatment platforms (theranostics). That is, anti-PSCA antibodies conjugated to the NPs, can carry fluorescent probes, radioisotopes, toxins, and chemotherapy drugs, to realize localized cancer cell targeting, imaging and therapy [ 138 ]. PSCA-based antibodies especially those based on CAR T cell immunotherapies are more popular and several are undergoing clinical trials (Table 6 ).…”

Section: Discussionmentioning

confidence: 99%

Significance of PSCA as a novel prognostic marker and therapeutic target for cancer

Nayerpour Dizaj,

Doustmihan,

Sadeghzadeh Oskouei

et al. 2024

Cancer Cell Int

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One of the contributing factors in the diagnosis and treatment of most cancers is the identification of their surface antigens. Cancer tissues or cells have their specific antigens. Some antigens that are present in many cancers elicit different functions. One of these antigens is the prostate stem cell antigen (PSCA) antigen, which was first identified in the prostate. PSCA is a cell surface protein that has different functions in different tissues. It can play an inhibitory role in cell proliferation as well as a tumor-inducing role. PSCA has several genetic variants involved in cancer susceptibility in some tissues, so identifying the characteristics of this antigen and its relationship with clinical features can provide more information on diagnosis and treatment of patients with cancers. Most studies on the PSCA have focused on prostate cancer. While it is also expressed in other cancers, little attention has been paid to its role as a valuable diagnostic, prognostic, and therapeutic tool in other cancers. PSCA has several genetic variants that seem to play a significant role in cancer susceptibility in some tissues, so identifying the characteristics of this antigen and its relationship and variants with clinical features can be beneficial in concomitant cancer therapy and diagnosis, as theranostic tools. In this study, we will review the alteration of the PSCA expression and its polymorphisms and evaluate its clinical and theranostics significance in various cancers.

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“…Fluorescence imaging technology's potential is particularly evident in the properties and characteristics of luminous nanoparticles (NPs), including inherent brightness, stability, spectral coverage, and tissue penetration depth [ [80] , [81] , [82] ]. Furthermore, advancements in computer technology, software, interactive programming, and the application of artificial intelligence (AI) in image processing present new challenges and opportunities for optical imaging technology [ [83] , [84] , [85] , [86] ]. The integration of multimedia technologies and software such as augmented reality (AR), virtual reality (VR), point capture, point-cloud reconstruction, digital modeling, and virtual reconstruction has led to innovations like 3D modeling of frame structures and CT 3D reconstruction in medical imaging [ [87] , [88] , [89] ].…”

Section: Characterization and Spectral Properties Of Semiconducting P...mentioning

confidence: 99%

Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

Zhang,

Yu,

et al. 2024

Materials Today Bio

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Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review

Cited by 23 publications

References 214 publications

Hyaluronic Acid-Targeted Niosomes for Effective Breast Cancer Chemostarvation Therapy

Hyaluronic Acid-Targeted Niosomes for Effective Breast Cancer Chemostarvation Therapy

Significance of PSCA as a novel prognostic marker and therapeutic target for cancer

Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

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