Molecular topology: a useful tool for the search of new antibacterials

Flavanones in grapefruit, lemons, and limes: A compilation and review of the data from the analytical literature

“…One or more of the citrus flavonoids may be responsible for their possible beneficial effects, although at present such evidence is limited chiefly to in vitro and mechanistic studies (Areias et al, 2001;Bae et al, 1999;Bear and Teel, 2000a, b;Borradaile et al, 1999;de Gregorio Alapont et al, 2000;Jeon et al, 2001;Kato et al, 2000;Kim et al, 2000;Kohno et al, 2001;Lee et al, 2001;Manthey et al, 2001;Miyake et al, 2000;Wilcox et al, 2001;Zhang et al, 2000). Therefore, it is important that the flavonoid composition of citrus fruits be documented so dietary intakes can be measured and linked to disease outcomes.…”

Flavanones in oranges, tangerines (mandarins), tangors, and tangelos: a compilation and review of the data from the analytical literature

“…Citrus fruits also appear to be associated with improved blood lipid profiles (Kurowska et al, 2000), and improved survival in the elderly (Fortes et al, 2000). The components responsible for these beneficial effects are unknown, but the citrus flavonoids are one group of compounds that may be involved (Areias et al, 2001;Bae et al, 1999;Bear and Teel 2000a, b;Borradaile et al, 1999;de Gregorio Alapont et al, 2000;Jeon et al, 2001;Kato et al, 2000;Kim et al, 2000;Kohno et al, 2001;Lee et al, 2001;Manthey et al, 2001;Miyagi et al, 2000;Miyake et al, 2000;Wilcox et al, 2001;Zhang et al, 2000).…”

Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure–activity relationship study

“…11 Many works using graph-theoretical approaches have been reported for the design of new drugs, to control toxicity parameters and to find common structural patterns of known drugs. The successful design of drugs like analgesics, 12 anti-virals, 13 anti-bacterials, 14 and anti-mycobacterials 15 have been reported using this method.…”